Improvement in Human Immune Function with Changes in Intestinal Microbiota by Salacia reticulata Extract Ingestion: A Randomized Placebo-Controlled Trial

Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cell...

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Published inPloS one Vol. 10; no. 12; p. e0142909
Main Authors Oda, Yuriko, Ueda, Fumitaka, Utsuyama, Masanori, Kamei, Asuka, Kakinuma, Chihaya, Abe, Keiko, Hirokawa, Katsuiku
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 02.12.2015
Public Library of Science (PLoS)
Subjects
Age
Animals
Bacteria
Biomarkers - metabolism
Blood
Blood cells
Cell proliferation
Clinical trials
Dendritic cells
Double-Blind Method
Eating
Epithelial cells
Gastrointestinal Microbiome - drug effects
Gene expression
Gene Expression Profiling
Genes
High-Throughput Nucleotide Sequencing - methods
Humans
Immune response
Immune system
Immunology
Ingestion
Intestinal microflora
Intestinal Mucosa - drug effects
Intestinal Mucosa - immunology
Intestinal Mucosa - metabolism
Intestinal Mucosa - microbiology
Intestine
Laboratories
Life sciences
Lymphocytes T
Male
Medical research
Methods
Microbiota
Microbiota (Symbiotic organisms)
Middle Aged
Older people
Pharmaceuticals
Plant Extracts - pharmacology
Polyphenols
Prebiotics
R&D
Rats
Research & development
Rodents
Salacia
Salacia - chemistry
Sugar
Japan
California
Online AccessGet full text

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Abstract Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. UMIN Clinical Trials Registry UMIN000011732.
AbstractList Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota.
Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. Trial Registration: UMIN Clinical Trials Registry UMIN000011732
Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S . reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S . reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. Trial Registration : UMIN Clinical Trials Registry UMIN000011732
Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S . reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S . reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. Trial Registration : UMIN Clinical Trials Registry UMIN000011732
Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota.UNLABELLEDPlants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota.UMIN Clinical Trials Registry UMIN000011732.TRIAL REGISTRATIONUMIN Clinical Trials Registry UMIN000011732.
Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. UMIN Clinical Trials Registry UMIN000011732.
Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota.UMIN Clinical Trials Registry UMIN000011732.
Audience Academic
Author Kamei, Asuka
Kakinuma, Chihaya
Oda, Yuriko
Ueda, Fumitaka
Abe, Keiko
Hirokawa, Katsuiku
Utsuyama, Masanori
AuthorAffiliation 4 Kanagawa Academy of Science and Technology, Kanagawa, Japan
5 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, Japan
1 Pharmaceutical and Healthcare Research Laboratories, Research and Development Management Headquarters, FUJIFILM Corporation, Kanagawa, Japan
2 Institute for Health and Life Science, Tokyo, Japan
Rush University, UNITED STATES
3 Department of Comprehensive Pathology, Tokyo Medical & Dental University, Tokyo, Japan
AuthorAffiliation_xml – name: 1 Pharmaceutical and Healthcare Research Laboratories, Research and Development Management Headquarters, FUJIFILM Corporation, Kanagawa, Japan
– name: 4 Kanagawa Academy of Science and Technology, Kanagawa, Japan
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– name: 3 Department of Comprehensive Pathology, Tokyo Medical & Dental University, Tokyo, Japan
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  surname: Kamei
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  surname: Abe
  fullname: Abe, Keiko
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  givenname: Katsuiku
  surname: Hirokawa
  fullname: Hirokawa, Katsuiku
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Competing Interests: The authors have the following interests: YO, FU, and CK are employed by Fujifilm Corporation. This does not alter the authors' adherence to all of the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Conceived and designed the experiments: YO FU CK KA KH. Performed the experiments: YO MU AK. Analyzed the data: YO FU MU AK KA. Contributed reagents/materials/analysis tools: YO MU AK. Wrote the paper: YO FU MU AK CK KA KH.
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PublicationDateYYYYMMDD 2015-12-02
PublicationDate_xml – month: 12
  year: 2015
  text: 2015-12-02
  day: 02
PublicationDecade 2010
PublicationPlace United States
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PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2015
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
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Snippet Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia...
Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia...
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StartPage e0142909
SubjectTerms Age
Animals
Bacteria
Biomarkers - metabolism
Blood
Blood cells
Cell proliferation
Clinical trials
Dendritic cells
Double-Blind Method
Eating
Epithelial cells
Gastrointestinal Microbiome - drug effects
Gene expression
Gene Expression Profiling
Genes
High-Throughput Nucleotide Sequencing - methods
Humans
Immune response
Immune system
Immunology
Ingestion
Intestinal microflora
Intestinal Mucosa - drug effects
Intestinal Mucosa - immunology
Intestinal Mucosa - metabolism
Intestinal Mucosa - microbiology
Intestine
Laboratories
Life sciences
Lymphocytes T
Male
Medical research
Methods
Microbiota
Microbiota (Symbiotic organisms)
Middle Aged
Older people
Pharmaceuticals
Plant Extracts - pharmacology
Polyphenols
Prebiotics
R&D
Rats
Research & development
Rodents
Salacia
Salacia - chemistry
Sugar
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Title Improvement in Human Immune Function with Changes in Intestinal Microbiota by Salacia reticulata Extract Ingestion: A Randomized Placebo-Controlled Trial
URI https://www.ncbi.nlm.nih.gov/pubmed/26630568
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https://pubmed.ncbi.nlm.nih.gov/PMC4667990
https://doaj.org/article/2f469002c1924aba9d7a05a552524ada
http://dx.doi.org/10.1371/journal.pone.0142909
Volume 10
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