Pharmacogenetics of microRNAs and microRNAs biogenesis machinery in pediatric acute lymphoblastic leukemia

• Published in: PloS one Vol. 9; no. 3; p. e91261
• Main Authors: López-López, Elixabet, Gutiérrez-Camino, Ángela, Piñán, Maria Ángeles, Sánchez-Toledo, José, Uriz, Jose Javier, Ballesteros, Javier, García-Miguel, Purificación, Navajas, Aurora, García-Orad, África
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.03.2014; Public Library of Science (PLoS)
• Subjects: Acute lymphocytic leukemia; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biology; Cancer treatment; Child; Female; Genes; Genetic aspects; Genetic polymorphisms; Genotyping Techniques; Humans; Linkage Disequilibrium - genetics; Male; Medicine; MicroRNA; MicroRNAs - biosynthesis; MicroRNAs - genetics; MicroRNAs - metabolism; Pharmacogenetics; Pharmacogenomics; Polymorphism, Single Nucleotide - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Proteins; RNA Processing, Post-Transcriptional - genetics

Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated the relationship between genetic variation and treatment-related toxicity. H...