Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep

Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to det...

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Published inPloS one Vol. 14; no. 11; p. e0214346
Main Authors Banos, Georgios, Clark, Emily L, Bush, Stephen J, Dutta, Prasun, Bramis, Georgios, Arsenos, Georgios, Hume, David A, Psifidi, Androniki
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 25.11.2019
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Abstract Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to determine the feasibility of a concomitant genetic improvement programme for enhanced milk production and resistance to mastitis. Individual records for milk yield, and four mastitis-related traits (milk somatic cell count, California Mastitis Test score, total viable bacterial count in milk and clinical mastitis presence) were collected monthly throughout lactation for 609 ewes of the Chios breed. All ewes were genotyped with a mastitis specific custom-made 960 single nucleotide polymorphism (SNP) array. We performed targeted genomic association studies, (co)variance component estimation and pathway enrichment analysis, and characterised gene expression levels and the extent of allelic expression imbalance. Presence of heritable variation for milk yield was confirmed. There was no significant genetic correlation between milk yield and mastitis traits. Environmental factors appeared to favour both milk production and udder health. There were no overlapping of SNPs associated with mastitis resistance and milk yield in Chios sheep. Furthermore, four distinct Quantitative Trait Loci (QTLs) affecting milk yield were detected on chromosomes 2, 12, 16 and 19, in locations other than those previously identified to affect mastitis resistance. Five genes (DNAJA1, GHR, LYPLA1, NUP35 and OXCT1) located within the QTL regions were highly expressed in both the mammary gland and milk transcriptome, suggesting involvement in milk synthesis and production. Furthermore, the expression of two of these genes (NUP35 and OXCT1) was enriched in immune tissues implying a potentially pleiotropic effect or likely role in milk production during udder infection, which needs to be further elucidated in future studies. In conclusion, the absence of genetic antagonism between milk yield and mastitis resistance suggests that simultaneous genetic improvement of both traits be achievable.
AbstractList Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to determine the feasibility of a concomitant genetic improvement programme for enhanced milk production and resistance to mastitis. Individual records for milk yield, and four mastitis-related traits (milk somatic cell count, California Mastitis Test score, total viable bacterial count in milk and clinical mastitis presence) were collected monthly throughout lactation for 609 ewes of the Chios breed. All ewes were genotyped with a mastitis specific custom-made 960 single nucleotide polymorphism (SNP) array. We performed targeted genomic association studies, (co)variance component estimation and pathway enrichment analysis, and characterised gene expression levels and the extent of allelic expression imbalance. Presence of heritable variation for milk yield was confirmed. There was no significant genetic correlation between milk yield and mastitis traits. Environmental factors appeared to favour both milk production and udder health. There were no overlapping of SNPs associated with mastitis resistance and milk yield in Chios sheep. Furthermore, four distinct Quantitative Trait Loci (QTLs) affecting milk yield were detected on chromosomes 2, 12, 16 and 19, in locations other than those previously identified to affect mastitis resistance. Five genes (DNAJA1, GHR, LYPLA1, NUP35 and OXCT1) located within the QTL regions were highly expressed in both the mammary gland and milk transcriptome, suggesting involvement in milk synthesis and production. Furthermore, the expression of two of these genes (NUP35 and OXCT1) was enriched in immune tissues implying a potentially pleiotropic effect or likely role in milk production during udder infection, which needs to be further elucidated in future studies. In conclusion, the absence of genetic antagonism between milk yield and mastitis resistance suggests that simultaneous genetic improvement of both traits be achievable.
Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to determine the feasibility of a concomitant genetic improvement programme for enhanced milk production and resistance to mastitis. Individual records for milk yield, and four mastitis-related traits (milk somatic cell count, California Mastitis Test score, total viable bacterial count in milk and clinical mastitis presence) were collected monthly throughout lactation for 609 ewes of the Chios breed. All ewes were genotyped with a mastitis specific custom-made 960 single nucleotide polymorphism (SNP) array. We performed targeted genomic association studies, (co)variance component estimation and pathway enrichment analysis, and characterised gene expression levels and the extent of allelic expression imbalance. Presence of heritable variation for milk yield was confirmed. There was no significant genetic correlation between milk yield and mastitis traits. Environmental factors appeared to favour both milk production and udder health. There were no overlapping of SNPs associated with mastitis resistance and milk yield in Chios sheep. Furthermore, four distinct Quantitative Trait Loci (QTLs) affecting milk yield were detected on chromosomes 2, 12, 16 and 19, in locations other than those previously identified to affect mastitis resistance. Five genes ( DNAJA1 , GHR , LYPLA1 , NUP35 and OXCT1 ) located within the QTL regions were highly expressed in both the mammary gland and milk transcriptome, suggesting involvement in milk synthesis and production. Furthermore, the expression of two of these genes ( NUP35 and OXCT1 ) was enriched in immune tissues implying a potentially pleiotropic effect or likely role in milk production during udder infection, which needs to be further elucidated in future studies. In conclusion, the absence of genetic antagonism between milk yield and mastitis resistance suggests that simultaneous genetic improvement of both traits be achievable.
Audience Academic
Author Bramis, Georgios
Arsenos, Georgios
Psifidi, Androniki
Dutta, Prasun
Hume, David A
Clark, Emily L
Bush, Stephen J
Banos, Georgios
AuthorAffiliation 1 Scotland’s Rural College, Edinburgh, Easter Bush, Midlothian, Scotland, United Kingdom
2 The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, Scotland, United Kingdom
4 Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, England, United Kingdom
5 Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Australia
6 Royal Veterinary College, University of London, Hatfield, England, United Kingdom
University of Florida, UNITED STATES
3 School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
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2019 Banos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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– notice: 2019 Banos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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SSID ssj0053866
Score 2.4059212
Snippet Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most...
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SourceType Open Website
Open Access Repository
Aggregation Database
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StartPage e0214346
SubjectTerms Analysis
Animal lactation
Animal welfare
Animals
Antagonism
Apoptosis
Biology and Life Sciences
California mastitis test
Cattle
Chromosomes
Dairy industry
Dairy products industry
Dairying
EDTA
Environmental factors
Feasibility Studies
Female
Future predictions
Gene expression
Gene mapping
Genes
Genetic analysis
Genetic improvement
Genetic polymorphisms
Genetic research
Genetics
Genomic analysis
Genomics
Goats
Lactation
Lactation - genetics
Lactation - physiology
Mammary gland
Mammary glands
Mastitis
Mastitis - genetics
Mastitis - veterinary
Medicine and Health Sciences
Milk
Milk production
Nucleotides
Oligonucleotide Array Sequence Analysis
Polymorphism
Polymorphism, Single Nucleotide
Quantitative genetics
Quantitative Trait Loci
Selective Breeding
Sheep
Sheep Diseases - genetics
Sheep, Domestic - classification
Sheep, Domestic - genetics
Sheep, Domestic - physiology
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Species Specificity
Udder
Veterinary colleges
Veterinary medicine
Yield
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Title Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep
URI https://www.ncbi.nlm.nih.gov/pubmed/31765378
https://www.proquest.com/docview/2317922958
https://pubmed.ncbi.nlm.nih.gov/PMC6876840
https://doaj.org/article/ea2e3de6da8849c6b3dd5343fddce981
http://dx.doi.org/10.1371/journal.pone.0214346
Volume 14
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