Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease

• Published in: PloS one Vol. 14; no. 11; p. e0224750
• Main Authors: Rogers, Lavida R. K., Verlinde, Madison, Mias, George I.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.11.2019; Public Library of Science (PLoS)
• Subjects: Age; Age Factors; Air Pollutants - adverse effects; Air pollution; Anopheles; Artificial intelligence; Biochemistry; Bioinformatics; Biological effects; Biology and Life Sciences; Biomarkers - metabolism; Biotechnology industries; Blood; Blood donation; Blood donors; Bronchitis; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Comparative analysis; Data Mining; Datasets; Datasets as Topic; Death; Diagnosis; Disease control; DNA microarrays; Down-Regulation; Female; Gene expression; Gene Expression Profiling - statistics & numerical data; Genes; Genomes; Humans; Immune response; Inflammation; Likelihood ratio; Logistic Models; Lung diseases; Lungs; Machine Learning; Male; Medical research; Medicine and Health Sciences; Models, Genetic; Obstructive lung disease; Oligonucleotide Array Sequence Analysis - statistics & numerical data; People and Places; Physical Sciences; Pollutants; Prevention; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - genetics; Quantiles; Regression analysis; Regression models; Research and Analysis Methods; Respiratory tract diseases; Risk Assessment - methods; Risk Factors; Sex; Sex Factors; Smoke; Smokers; Smoking; Smoking - adverse effects; Smoking - epidemiology; Social Sciences; Statistical analysis; Statistical methods; Tobacco; Tobacco smoke; Transcriptome - genetics; United States - epidemiology; Up-Regulation; United States; United States > US; East Lansing Michigan; Michigan

Chronic obstructive pulmonary disease (COPD) was classified by the Centers for Disease Control and Prevention in 2014 as the 3rd leading cause of death in the United States (US). The main cause of COPD is exposure to tobacco smoke and air pollutants. Problems associated with COPD include under-diagn...