Dopamine and sense of agency: Determinants in personality and substance use

• Published in: PloS one Vol. 14; no. 3; p. e0214069
• Main Authors: Render, Anna, Jansen, Petra
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.03.2019; Public Library of Science (PLoS)
• Subjects: Accessibility; Adolescent; Adult; Analysis; Bias; Binding; Biology and Life Sciences; Cannabis; Cardiotonic agents; Cocaine; Cognition & reasoning; Cognitive ability; Consciousness; Dopamine; Dopamine - metabolism; Dopamine receptors; Dosage and administration; Drug use; Female; Free will; Genetics; Humans; Influence; Intention; Male; Marijuana; MDMA; Medicine and Health Sciences; Narcissism; Perception; Perceptions; Personality; Personality (Psychology); Phenols (Class of compounds); Physical Sciences; Psychosis; Risk factors; Schizophrenia; Self esteem; Social Sciences; Sport science; Studies; Substance abuse; Substance use; Substance-Related Disorders - metabolism; Substance-Related Disorders - psychology; Bavaria Germany; Germany
• DOI: 10.1371/journal.pone.0214069
• ISSN: 1932-6203

Sense of agency refers to the feeling of control over one's own actions. The strength of this sense varies inter-individually. This means that people differ in their perception concerning the intensity of their intentions and actions. The current study aims to determine the factors influencing this sense of agency on a personality level. Furthermore, it gives insight into the correlative relation between the strength of the sense of agency and substance use. The study involved 210 participants who were tested for the experiment (intentional binding paradigm for sense of agency, hand paradigm for intentionality bias, questionnaires FAD-Plus, NI-20, substance use). Significant determinants in personality were narcissism (vulnerable subtype) and substance use (consumption in general beyond cannabis, and particularly for the substances cannabis, ecstasy, and cocaine). Both personality types were associated with a weaker sense of agency compared to controls. For both results, alterations in the dopaminergic system need to be discussed. The present results confirm prior hypotheses that dopamine seems to play a crucial role in perception of agency. Possibly a higher accessibility of dopamine increases sense of agency (hyper-binding), whereas a lower accessibility of dopamine decreases sense of agency (hypo-binding). A second aim of the study was to see whether there is a connection between sense of agency and intentionality bias. The perception of intention in others differs widely; some people tend to see arbitrary or accidental actions as unintentional, and others quickly label actions as 'intentional' although the information is not distinct for a categorization. This cognitive error is called intentionality bias. Results could not confirm a relationship between the two constructs-one's own intention and judging intention in others. This may be due to a lack of connection between the two constructs or to methodological aspects. Further directions and limitations are discussed.