Genetic Variants in RKIP Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population

• Published in: PloS one Vol. 9; no. 10; p. e109285
• Main Authors: Cao, Qiang, Wang, Jian, Zhang, Mingcong, Li, Pu, Qian, Jian, Zhang, Shaobo, Zhang, Lei, Ju, Xiaobing, Wang, Meilin, Zhang, Zhengdong, Li, Jie, Gu, Min, Zhang, Wei, Qin, Chao, Shao, Pengfei, Yin, Changjun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.10.2014; Public Library of Science (PLoS)
• Subjects: 3' Untranslated regions; Apoptosis; Asian Continental Ancestry Group - genetics; Biology and Life Sciences; Bladder cancer; Breast cancer; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - pathology; Case-Control Studies; Cell adhesion & migration; Cell growth; Clear cell-type renal cell carcinoma; Colorectal cancer; Development and progression; Diabetes mellitus; Enzyme inhibitors; Female; Gene expression; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease - genetics; Genetic variance; Hospitals; Humans; Kidney cancer; Kinases; Laboratories; Liver cancer; Male; Medical prognosis; Medicine; Medicine and Health Sciences; Melanoma; Metastasis; Middle Aged; mRNA; Phosphatidylethanolamine Binding Protein - genetics; Polymorphism; Polymorphism, Single Nucleotide; Prostate cancer; Protein expression; Proteins; Raf protein; Regression analysis; Renal cell carcinoma; Reproductive health; Risk; Risk factors; RNA; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Subgroups; Survival analysis; Tagging; Tissues; Toxicology; Tumorigenesis; Urology; China

Raf-1 kinase inhibitor protein (RKIP) plays a critical role in tumor development by regulating cell functions such as invasion, apoptosis and differentiation. Down-regulation of RKIP expression has been implicated in the development and progression of renal cell carcinoma (RCC). Herein, we hypothesi...