Differences in Unfolded Protein Response Pathway Activation in the Lenses of Three Types of Cataracts

• Published in: PloS one Vol. 10; no. 6; p. e0130705
• Main Authors: Yang, Jing, Zhou, Sheng, Gu, Jianjun, Wang, Yujuan, Guo, Minfei, Liu, Yizhi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.06.2015; Public Library of Science (PLoS)
• Subjects: Activating Transcription Factor 4 - genetics; Activating Transcription Factor 4 - metabolism; Activating Transcription Factor 6 - genetics; Activating Transcription Factor 6 - metabolism; Activation; Age; Cataract - metabolism; Cataract - pathology; Cataracts; Cyprinus carpio; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Endoplasmic reticulum; Endoribonucleases - metabolism; Eukaryotic Initiation Factor-2 - metabolism; Eye lens; Eye surgery; Gene expression; Genetic disorders; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Humans; Kinases; Laboratories; Lens, Crystalline - metabolism; Lenses; Membranes; Myopia; Ophthalmology; Patients; Protein folding; Protein-Serine-Threonine Kinases - metabolism; Proteins; Real-Time Polymerase Chain Reaction; Regulation; Regulatory Factor X Transcription Factors; RNA Splicing; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stress response; Surgery; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Unfolded Protein Response - physiology; Up-Regulation; Western blotting; X-Box Binding Protein 1; China

To investigate the activation of three unfolded protein response (UPR) pathways in the lenses of age-related, high myopia-related and congenital cataracts. Lens specimens were collected from patients during small incision cataract surgery. Lenses from young cadaver eyes were collected as normal cont...