Predictive Value of Updating Framingham Risk Scores with Novel Risk Markers in the U.S. General Population

• Published in: PloS one Vol. 9; no. 2; p. e88312
• Main Authors: Ferket, Bart S., van Kempen, Bob J. H., Hunink, M. G. Myriam, Agarwal, Isha, Kavousi, Maryam, Franco, Oscar H., Steyerberg, Ewout W., Max, Wendy, Fleischmann, Kirsten E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2014; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Ankle; Ankle Brachial Index; Biology; Biomarkers - metabolism; Blood pressure measurement; C-reactive protein; Calcium; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Carotid Intima-Media Thickness; Cohort analysis; Cohort Studies; Coronary heart disease; Cost analysis; Cost benefit analysis; Female; Health risk assessment; Health risks; Humans; Male; Markers; Medicine; Meta-analysis; Middle Aged; Nutrition; Nutrition Surveys; Population statistics; Population studies; Predictive Value of Tests; Proportional Hazards Models; Reclassification; Risk assessment; Risk Factors; Surveys; Systematic review; Treatment Outcome; United States - epidemiology; United States; San Francisco California; Netherlands; California; United States > US; Massachusetts

According to population-based cohort studies CT coronary calcium score (CTCS), carotid intima-media thickness (cIMT), high-sensitivity C- reactive protein (CRP), and ankle-brachial index (ABI) are promising novel risk markers for improving cardiovascular risk assessment. Their impact in the U.S. gen...