The Role of the bHLH Protein Hairy in Morphogenetic Furrow Progression in the Developing Drosophila Eye
In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene dau...
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| Published in | PloS one Vol. 7; no. 10; p. e47503 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
31.10.2012
Public Library of Science (PLoS) |
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| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0047503 |
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| Abstract | In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene daughterless as one of the main functions of extramacrochaete. Here the role of hairy was assessed in relation to daughterless and other HLH genes. Hairy was not found to regulate the expression of Daughterless, Extramacrochaete or Atonal, and Hairy expression was largely unregulated by these other genes. Null alleles of hairy did not alter the rate or pattern of differentiation, either alone or in the absence of Extramacrochaete. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete. |
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| AbstractList | In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene daughterless as one of the main functions of extramacrochaete. Here the role of hairy was assessed in relation to daughterless and other HLH genes. Hairy was not found to regulate the expression of Daughterless, Extramacrochaete or Atonal, and Hairy expression was largely unregulated by these other genes. Null alleles of hairy did not alter the rate or pattern of differentiation, either alone or in the absence of Extramacrochaete. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete. In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene daughterless as one of the main functions of extramacrochaete . Here the role of hairy was assessed in relation to daughterless and other HLH genes. Hairy was not found to regulate the expression of Daughterless, Extramacrochaete or Atonal, and Hairy expression was largely unregulated by these other genes. Null alleles of hairy did not alter the rate or pattern of differentiation, either alone or in the absence of Extramacrochaete. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila , alone or redundantly with extramacrochaete . In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene daughterless as one of the main functions of extramacrochaete. Here the role of hairy was assessed in relation to daughterless and other HLH genes. Hairy was not found to regulate the expression of Daughterless, Extramacrochaete or Atonal, and Hairy expression was largely unregulated by these other genes. Null alleles of hairy did not alter the rate or pattern of differentiation, either alone or in the absence of Extramacrochaete. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete.In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene daughterless as one of the main functions of extramacrochaete. Here the role of hairy was assessed in relation to daughterless and other HLH genes. Hairy was not found to regulate the expression of Daughterless, Extramacrochaete or Atonal, and Hairy expression was largely unregulated by these other genes. Null alleles of hairy did not alter the rate or pattern of differentiation, either alone or in the absence of Extramacrochaete. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete. |
| Audience | Academic |
| Author | Baker, Nicholas E. Bhattacharya, Abhishek |
| AuthorAffiliation | 2 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America 3 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York, United States of America VIB and KU Leuven, Belgium 1 Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America |
| AuthorAffiliation_xml | – name: 3 Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York, United States of America – name: 2 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America – name: 1 Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America – name: VIB and KU Leuven, Belgium |
| Author_xml | – sequence: 1 givenname: Abhishek surname: Bhattacharya fullname: Bhattacharya, Abhishek – sequence: 2 givenname: Nicholas E. surname: Baker fullname: Baker, Nicholas E. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23118874$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2012 Public Library of Science 2012 Bhattacharya, Baker. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2012 Bhattacharya, Baker 2012 Bhattacharya, Baker |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: AB NB. Performed the experiments: AB. Analyzed the data: AB NB. Wrote the paper: AB NB. Competing Interests: The authors have declared that no competing interests exist. Current address: Department of Biochemistry and Molecular Biophysics, Columbia College of Physicians and Surgeons, New York, New York, United States of America |
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| SubjectTerms | Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biology Cell Differentiation - genetics Cloning Deoxyribonucleic acid Differentiation DNA DNA-Binding Proteins Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Eye Eye - growth & development Eye - metabolism Furrows Gene expression Gene Expression Regulation, Developmental Genes Helix-loop-helix proteins (basic) Imaginal Discs - growth & development Imaginal Discs - metabolism Insect Proteins - genetics Insect Proteins - metabolism Insects Medicine Morphogenesis Mutation Negative feedback Neurogenesis Photoreceptors Proteins Regulation Repressor Proteins - genetics Repressor Proteins - metabolism Retina Retina - growth & development Retina - metabolism Signal Transduction - genetics |
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| Title | The Role of the bHLH Protein Hairy in Morphogenetic Furrow Progression in the Developing Drosophila Eye |
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