Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates

• Published in: PloS one Vol. 10; no. 8; p. e0137078
• Main Authors: Kim, Aeryun, Servetas, Stephanie L, Kang, Jieun, Kim, Jinmoon, Jang, Sungil, Cha, Ho Jin, Lee, Wan Jin, Kim, June, Romero-Gallo, Judith, Peek, Jr, Richard M, Merrell, D Scott, Cha, Jeong-Heon
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Antigens; Antigens, Bacterial - genetics; Bacterial Outer Membrane Proteins - genetics; Bacterial Proteins - genetics; Biology; Blood groups; Clinical isolates; Colonization; Dentistry; Disease; Female; Gastric cancer; Gastric mucosa; Genes; Genetic aspects; Genetic diversity; Genetic Variation; Genomes; Genomics; Genotype; Genotypes; Genotyping; Genotyping Techniques; Geographical distribution; Health sciences; Helicobacter pylori; Helicobacter pylori - classification; Helicobacter pylori - genetics; Helicobacter pylori - isolation & purification; Hospitals; Host-bacteria relationships; Humans; Identification and classification; Immunology; Infections; Life sciences; Loci; Male; Membrane proteins; Microbiological research; Middle Aged; Outer membrane proteins; Pathogens; Phylogeny; Proteins; Republic of Korea; Sequence Homology, Nucleic Acid; Stomach cancer; Ulcers; United States; Virulence; Virulence (Microbiology); Virulence factors; United States; Republic of Korea; South Korea; United States > US; Maryland; Tennessee; Nashville Tennessee

Helicobacter pylori genetic variation is a crucial component of colonization and persistence within the inhospitable niche of the gastric mucosa. As such, numerous H. pylori genes have been shown to vary in terms of presence and genomic location within this pathogen. Among the variable factors, the...