Cerebrospinal Fluid Extracellular Vesicles Undergo Age Dependent Declines and Contain Known and Novel Non-coding RNAs

• Published in: PloS one Vol. 9; no. 11; p. e113116
• Main Authors: Tietje, Ashlee, Maron, Kourtney N., Wei, Yanzhang, Feliciano, David M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.11.2014; Public Library of Science (PLoS)
• Subjects: Adolescent; Age; Age Factors; Aged; Aged, 80 and over; Base Sequence; Biology and life sciences; Brain; Cell culture; Cell signaling; Cell-Derived Microparticles - genetics; Cell-Derived Microparticles - metabolism; Cell-Derived Microparticles - ultrastructure; Central nervous system; Cerebrospinal fluid; Cerebrospinal Fluid - metabolism; Child; Choroid plexus; Choroid Plexus - cytology; Choroid Plexus - metabolism; Coding; Conserved sequence; DNA microarrays; Epithelial cells; Epithelial Cells - metabolism; Exosomes; Exosomes - genetics; Exosomes - metabolism; Exosomes - ultrastructure; Extracellular vesicles; Fluids; Gene sequencing; Heparan sulfate; Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism; High-Throughput Nucleotide Sequencing; Humans; Immunoblotting; Infant; Infant, Newborn; Lipids; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Microscopy; Microscopy, Electron, Transmission; miRNA; Nanoparticles; Non-coding RNA; Nucleic acids; Oligonucleotide Array Sequence Analysis; Physiology; Proteins; Ribonucleic acid; RNA; RNA, Untranslated - cerebrospinal fluid; RNA, Untranslated - genetics; Sequence Homology, Nucleic Acid; Stem cells; Vesicles; United Kingdom > UK; United States > US; South Carolina

Brain development requires precise orchestration of cellular events through the coordinate exchange of information between distally located cells. One mechanism by which intercellular communication is achieved is through the transfer of extracellular vesicles (EVs). Exosomes are EVs that carry lipid...