Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model

• Published in: PloS one Vol. 11; no. 4; p. e0151832
• Main Authors: MacDiarmid, Jennifer A, Langova, Veronika, Bailey, Dale, Pattison, Scott T, Pattison, Stacey L, Christensen, Neil, Armstrong, Luke R, Brahmbhatt, Vatsala N, Smolarczyk, Katarzyna, Harrison, Matthew T, Costa, Marylia, Mugridge, Nancy B, Sedliarou, Ilya, Grimes, Nicholas A, Kiss, Debra L, Stillman, Bruce, Hann, Christine L, Gallia, Gary L, Graham, Robert M, Brahmbhatt, Himanshu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.04.2016; Public Library of Science (PLoS)
• Subjects: Analysis; Animal experimentation; Animals; Antibiotics, Antineoplastic - pharmacokinetics; Antibiotics, Antineoplastic - therapeutic use; Antibodies, Monoclonal - therapeutic use; Bacteria; Biochemistry; Bioindicators; Biology and Life Sciences; Blood-brain barrier; Brain; Brain cancer; Brain Neoplasms - drug therapy; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Brain research; Brain tumors; Cancer; Cancer therapies; Care and treatment; Cell Proliferation - drug effects; Chemotherapy; Computed tomography; Cytotoxicity; Diagnosis; Disease Models, Animal; Dogs; Dosage and administration; Doxorubicin; Doxorubicin - pharmacokinetics; Doxorubicin - therapeutic use; Drug Delivery Systems; Emission analysis; Epidermal growth factor; Epidermal growth factor receptors; Female; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - mortality; Glioblastoma - pathology; Hematology; Humans; Inflammation; Intravenous administration; Magnetic resonance; Magnetic resonance imaging; Male; Medical diagnosis; Medical prognosis; Medical research; Medicine; Medicine and Health Sciences; Minicells; Molecular Targeted Therapy; Nanoparticles; Neoplasm Staging; Neuroimaging; Oncology; Patients; Permeability; Photon emission; Receptor, Epidermal Growth Factor; Regression analysis; Remission; Research and Analysis Methods; Single photon emission computed tomography; Studies; Survival Rate; Therapeutic applications; Tissue Distribution; Tissues; Toxicity; Toxicology; Tumor Cells, Cultured; Tumors

Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derive...