Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model - MacDiarmid, Jennifer A.; Langova, Veronika; Bailey, Dale; Pattison, Scott T.; Pattison, Stacey L.; Christensen, Neil; Armstrong, Luke R.; Brahmbhatt, Vatsala N.; Smolarczyk, Katarzyna; Harrison, Matthew T.; Costa, Marylia; Mugridge, Nancy B.; et al. (PloS one, 2016)
Keywords: Analysis; Animal experimentation; Animals; Antibiotics, Antineoplastic - pharmacokinetics; Antibiotics, Antineoplastic - therapeutic use; Antibodies, Monoclonal - therapeutic use; Bacteria; Biochemistry; Bioindicators; Biology and Life Sciences; Blood-brain barrier; Brain; Brain cancer; Brain Neoplasms - drug therapy; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Brain research; Brain tumors; Cancer; Cancer therapies; Care and treatment; Cell Proliferation - drug effects; Chemotherapy; Computed tomography; Cytotoxicity; Diagnosis; Disease Models, Animal; Dogs; Dosage and administration; Doxorubicin; Doxorubicin - pharmacokinetics; Doxorubicin - therapeutic use; Drug Delivery Systems; Emission analysis; Epidermal growth factor; Epidermal growth factor receptors; Female; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - mortality; Glioblastoma - pathology; Hematology; Humans; Inflammation; Intravenous administration; Magnetic resonance; Magnetic resonance imaging; Male; Medical diagnosis; Medical prognosis; Medical research; Medicine; Medicine and Health Sciences; Minicells; Molecular Targeted Therapy; Nanoparticles; Neoplasm Staging; Neuroimaging; Oncology; Patients; Permeability; Photon emission; Receptor, Epidermal Growth Factor; Regression analysis; Remission; Research and Analysis Methods; Single photon emission computed tomography; Studies; Survival Rate; Therapeutic applications; Tissue Distribution; Tissues; Toxicity; Toxicology; Tumor Cells, Cultured; Tumors