Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model
Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derive...
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| Published in | PloS one Vol. 11; no. 4; p. e0151832 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
06.04.2016
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derived minicells to deliver the potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated EGFRminicellsDox) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers.
EGFRminicellsDox were administered weekly via intravenous injection to 17 dogs with late-stage brain cancers. Biodistribution was assessed using single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Anti-tumor response was determined using MRI, and blood samples were subject to toxicology (hematology, biochemistry) and inflammatory marker analysis. Targeted, doxorubicin-loaded minicells rapidly localized to the core of brain tumors. Complete resolution or marked tumor regression (>90% reduction in tumor volume) were observed in 23.53% of the cohort, with lasting anti-tumor responses characterized by remission in three dogs for more than two years. The median overall survival was 264 days (range 49 to 973). No adverse clinical, hematological or biochemical effects were observed with repeated administration of EGFRminicellsDox (30 to 98 doses administered in 10 of the 17 dogs).
Targeted minicells loaded with doxorubicin were safely administered to dogs with late stage brain cancer and clinical activity was observed. These findings demonstrate the strong potential for clinical applications of targeted, doxorubicin-loaded minicells for the effective treatment of patients with brain cancer. On this basis, we have designed a Phase 1 clinical study of EGFR-targeted, doxorubicin-loaded minicells for effective treatment of human patients with recurrent glioblastoma. |
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| AbstractList | Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derived minicells to deliver the potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated EGFRminicellsDox) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers.EGFRminicellsDox were administered weekly via intravenous injection to 17 dogs with late-stage brain cancers. Biodistribution was assessed using single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Anti-tumor response was determined using MRI, and blood samples were subject to toxicology (hematology, biochemistry) and inflammatory marker analysis. Targeted, doxorubicin-loaded minicells rapidly localized to the core of brain tumors. Complete resolution or marked tumor regression (>90% reduction in tumor volume) were observed in 23.53% of the cohort, with lasting anti-tumor responses characterized by remission in three dogs for more than two years. The median overall survival was 264 days (range 49 to 973). No adverse clinical, hematological or biochemical effects were observed with repeated administration of EGFRminicellsDox (30 to 98 doses administered in 10 of the 17 dogs).Targeted minicells loaded with doxorubicin were safely administered to dogs with late stage brain cancer and clinical activity was observed. These findings demonstrate the strong potential for clinical applications of targeted, doxorubicin-loaded minicells for the effective treatment of patients with brain cancer. On this basis, we have designed a Phase 1 clinical study of EGFR-targeted, doxorubicin-loaded minicells for effective treatment of human patients with recurrent glioblastoma. Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derived minicells to deliver the potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated .sup.EGFR minicells.sub.Dox) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers. .sup.EGFR minicells.sub.Dox were administered weekly via intravenous injection to 17 dogs with late-stage brain cancers. Biodistribution was assessed using single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Anti-tumor response was determined using MRI, and blood samples were subject to toxicology (hematology, biochemistry) and inflammatory marker analysis. Targeted, doxorubicin-loaded minicells rapidly localized to the core of brain tumors. Complete resolution or marked tumor regression (>90% reduction in tumor volume) were observed in 23.53% of the cohort, with lasting anti-tumor responses characterized by remission in three dogs for more than two years. The median overall survival was 264 days (range 49 to 973). No adverse clinical, hematological or biochemical effects were observed with repeated administration of .sup.EGFR minicells.sub.Dox (30 to 98 doses administered in 10 of the 17 dogs). Targeted minicells loaded with doxorubicin were safely administered to dogs with late stage brain cancer and clinical activity was observed. These findings demonstrate the strong potential for clinical applications of targeted, doxorubicin-loaded minicells for the effective treatment of patients with brain cancer. On this basis, we have designed a Phase 1 clinical study of EGFR-targeted, doxorubicin-loaded minicells for effective treatment of human patients with recurrent glioblastoma. Background Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derived minicells to deliver the potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated .sup.EGFR minicells.sub.Dox) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers. Methodology/Principle Findings .sup.EGFR minicells.sub.Dox were administered weekly via intravenous injection to 17 dogs with late-stage brain cancers. Biodistribution was assessed using single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Anti-tumor response was determined using MRI, and blood samples were subject to toxicology (hematology, biochemistry) and inflammatory marker analysis. Targeted, doxorubicin-loaded minicells rapidly localized to the core of brain tumors. Complete resolution or marked tumor regression (>90% reduction in tumor volume) were observed in 23.53% of the cohort, with lasting anti-tumor responses characterized by remission in three dogs for more than two years. The median overall survival was 264 days (range 49 to 973). No adverse clinical, hematological or biochemical effects were observed with repeated administration of .sup.EGFR minicells.sub.Dox (30 to 98 doses administered in 10 of the 17 dogs). Conclusions/Significance Targeted minicells loaded with doxorubicin were safely administered to dogs with late stage brain cancer and clinical activity was observed. These findings demonstrate the strong potential for clinical applications of targeted, doxorubicin-loaded minicells for the effective treatment of patients with brain cancer. On this basis, we have designed a Phase 1 clinical study of EGFR-targeted, doxorubicin-loaded minicells for effective treatment of human patients with recurrent glioblastoma. Background Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derived minicells to deliver the potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated EGFR minicells Dox ) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers. Methodology/Principle Findings EGFR minicells Dox were administered weekly via intravenous injection to 17 dogs with late-stage brain cancers. Biodistribution was assessed using single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Anti-tumor response was determined using MRI, and blood samples were subject to toxicology (hematology, biochemistry) and inflammatory marker analysis. Targeted, doxorubicin-loaded minicells rapidly localized to the core of brain tumors. Complete resolution or marked tumor regression (>90% reduction in tumor volume) were observed in 23.53% of the cohort, with lasting anti-tumor responses characterized by remission in three dogs for more than two years. The median overall survival was 264 days (range 49 to 973). No adverse clinical, hematological or biochemical effects were observed with repeated administration of EGFR minicells Dox (30 to 98 doses administered in 10 of the 17 dogs). Conclusions/Significance Targeted minicells loaded with doxorubicin were safely administered to dogs with late stage brain cancer and clinical activity was observed. These findings demonstrate the strong potential for clinical applications of targeted, doxorubicin-loaded minicells for the effective treatment of patients with brain cancer. On this basis, we have designed a Phase 1 clinical study of EGFR-targeted, doxorubicin-loaded minicells for effective treatment of human patients with recurrent glioblastoma. Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derived minicells to deliver the potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated EGFRminicellsDox) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers. EGFRminicellsDox were administered weekly via intravenous injection to 17 dogs with late-stage brain cancers. Biodistribution was assessed using single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Anti-tumor response was determined using MRI, and blood samples were subject to toxicology (hematology, biochemistry) and inflammatory marker analysis. Targeted, doxorubicin-loaded minicells rapidly localized to the core of brain tumors. Complete resolution or marked tumor regression (>90% reduction in tumor volume) were observed in 23.53% of the cohort, with lasting anti-tumor responses characterized by remission in three dogs for more than two years. The median overall survival was 264 days (range 49 to 973). No adverse clinical, hematological or biochemical effects were observed with repeated administration of EGFRminicellsDox (30 to 98 doses administered in 10 of the 17 dogs). Targeted minicells loaded with doxorubicin were safely administered to dogs with late stage brain cancer and clinical activity was observed. These findings demonstrate the strong potential for clinical applications of targeted, doxorubicin-loaded minicells for the effective treatment of patients with brain cancer. On this basis, we have designed a Phase 1 clinical study of EGFR-targeted, doxorubicin-loaded minicells for effective treatment of human patients with recurrent glioblastoma. Background Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derived minicells to deliver the potent chemotherapeutic doxorubicin via epidermal growth factor receptor (EGFR) targeting. Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated EGFRminicellsDox) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers. Methodology/Principle Findings EGFRminicellsDox were administered weekly via intravenous injection to 17 dogs with late-stage brain cancers. Biodistribution was assessed using single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Anti-tumor response was determined using MRI, and blood samples were subject to toxicology (hematology, biochemistry) and inflammatory marker analysis. Targeted, doxorubicin-loaded minicells rapidly localized to the core of brain tumors. Complete resolution or marked tumor regression (>90% reduction in tumor volume) were observed in 23.53% of the cohort, with lasting anti-tumor responses characterized by remission in three dogs for more than two years. The median overall survival was 264 days (range 49 to 973). No adverse clinical, hematological or biochemical effects were observed with repeated administration of EGFRminicellsDox (30 to 98 doses administered in 10 of the 17 dogs). Conclusions/Significance Targeted minicells loaded with doxorubicin were safely administered to dogs with late stage brain cancer and clinical activity was observed. These findings demonstrate the strong potential for clinical applications of targeted, doxorubicin-loaded minicells for the effective treatment of patients with brain cancer. On this basis, we have designed a Phase 1 clinical study of EGFR-targeted, doxorubicin-loaded minicells for effective treatment of human patients with recurrent glioblastoma. |
| Audience | Academic |
| Author | Gallia, Gary L Christensen, Neil Stillman, Bruce Harrison, Matthew T Costa, Marylia Mugridge, Nancy B Langova, Veronika Brahmbhatt, Vatsala N Grimes, Nicholas A Smolarczyk, Katarzyna Sedliarou, Ilya Armstrong, Luke R Bailey, Dale Pattison, Stacey L Brahmbhatt, Himanshu Kiss, Debra L Hann, Christine L MacDiarmid, Jennifer A Pattison, Scott T Graham, Robert M |
| AuthorAffiliation | 3 Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia 6 Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America 2 Small Animal Specialist Hospital, Sydney, New South Wales, Australia 4 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America 8 University of New South Wales, Sydney, New South Wales, Australia 1 Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia 7 Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia 5 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Bauer Research Foundation, UNITED STATES |
| AuthorAffiliation_xml | – name: 7 Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia – name: 6 Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America – name: Bauer Research Foundation, UNITED STATES – name: 2 Small Animal Specialist Hospital, Sydney, New South Wales, Australia – name: 3 Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia – name: 1 Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – name: 8 University of New South Wales, Sydney, New South Wales, Australia – name: 4 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America – name: 5 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America |
| Author_xml | – sequence: 1 givenname: Jennifer A surname: MacDiarmid fullname: MacDiarmid, Jennifer A organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 2 givenname: Veronika surname: Langova fullname: Langova, Veronika organization: Small Animal Specialist Hospital, Sydney, New South Wales, Australia – sequence: 3 givenname: Dale surname: Bailey fullname: Bailey, Dale organization: Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia – sequence: 4 givenname: Scott T surname: Pattison fullname: Pattison, Scott T organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 5 givenname: Stacey L surname: Pattison fullname: Pattison, Stacey L organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 6 givenname: Neil surname: Christensen fullname: Christensen, Neil organization: Small Animal Specialist Hospital, Sydney, New South Wales, Australia – sequence: 7 givenname: Luke R surname: Armstrong fullname: Armstrong, Luke R organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 8 givenname: Vatsala N surname: Brahmbhatt fullname: Brahmbhatt, Vatsala N organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 9 givenname: Katarzyna surname: Smolarczyk fullname: Smolarczyk, Katarzyna organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 10 givenname: Matthew T surname: Harrison fullname: Harrison, Matthew T organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 11 givenname: Marylia surname: Costa fullname: Costa, Marylia organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 12 givenname: Nancy B surname: Mugridge fullname: Mugridge, Nancy B organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 13 givenname: Ilya surname: Sedliarou fullname: Sedliarou, Ilya organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 14 givenname: Nicholas A surname: Grimes fullname: Grimes, Nicholas A organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 15 givenname: Debra L surname: Kiss fullname: Kiss, Debra L organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia – sequence: 16 givenname: Bruce surname: Stillman fullname: Stillman, Bruce organization: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America – sequence: 17 givenname: Christine L surname: Hann fullname: Hann, Christine L organization: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America – sequence: 18 givenname: Gary L surname: Gallia fullname: Gallia, Gary L organization: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America – sequence: 19 givenname: Robert M surname: Graham fullname: Graham, Robert M organization: University of New South Wales, Sydney, New South Wales, Australia – sequence: 20 givenname: Himanshu surname: Brahmbhatt fullname: Brahmbhatt, Himanshu organization: Cancer Therapeutics, EnGeneIC Pty Ltd, Sydney, New South Wales, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27050167$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | COPYRIGHT 2016 Public Library of Science 2016 MacDiarmid et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 MacDiarmid et al 2016 MacDiarmid et al |
| Copyright_xml | – notice: COPYRIGHT 2016 Public Library of Science – notice: 2016 MacDiarmid et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2016 MacDiarmid et al 2016 MacDiarmid et al |
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| DOI | 10.1371/journal.pone.0151832 |
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| DocumentTitleAlternate | Dog Brain Cancers Treated with Modified Minicells |
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| Editor | Bauer, Joseph Alan |
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| Notes | Conceived and designed the experiments: HB JAM. Performed the experiments: JAM VL DB STP SLP NC LRA VNB KS MTH NBM IS HB. Analyzed the data: JAM VL DB STP SLP NC MTH MC NBM IS NAG DLK BS CLH GLG RMG HB. Contributed reagents/materials/analysis tools: VL STP SLP NC LRA VNB KS MTH NBM IS. Wrote the paper: JAM VL DB HB. Competing Interests: EnGeneIC Pty Ltd funded the salaries for authors JAM, STP, SLP, LRA, VNB, KS, MTH, MC, NBM, IS, NAG, DLK, HB. Authors JAM, HB, NBM, STP, SLP, RMG, BS are shareholders in EnGeneIC Pty Ltd. All other authors declare that no competing interests exist. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. |
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| Snippet | Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes... Background Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often... Background Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often... |
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| Title | Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27050167 https://www.proquest.com/docview/1779034164 https://pubmed.ncbi.nlm.nih.gov/PMC4822833 https://doaj.org/article/e116e1cea4c448e58b0ddb5f6f713be5 http://dx.doi.org/10.1371/journal.pone.0151832 |
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