Alterations in Hypothalamus-Pituitary-Adrenal/Thyroid Axes and Gonadotropin-Releasing Hormone in the Patients with Primary Insomnia: A Clinical Research

• Published in: PloS one Vol. 8; no. 8; p. e71065
• Main Authors: Xia, Lan, Chen, Gui-Hai, Li, Zhi-Hua, Jiang, Song, Shen, Jianhua
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.08.2013; Public Library of Science (PLoS)
• Subjects: Adrenocorticotropic hormone; Adrenocorticotropic Hormone - blood; Adult; Biology; Bipolar disorder; Brain research; Case-Control Studies; Clinical trials; Correlation analysis; Corticotropin; Corticotropin-releasing hormone; Corticotropin-Releasing Hormone - blood; Cortisol; Endocrinology; Eye movements; Family medical history; Female; Gene expression; Glucocorticoids; Glycoproteins; Gonadotropin-releasing hormone; Gonadotropin-Releasing Hormone - blood; Gonadotropins; Hormones; Hospitals; Humans; Hydrocortisone - blood; Hypothalamo-Hypophyseal System - metabolism; Hypothalamo-Hypophyseal System - physiopathology; Hypothalamus; Hypothyroidism; Insomnia; Male; Medical research; Medicine; Mental depression; Middle Aged; Morning; Neurology; Patients; Pituitary; Pituitary (anterior); Pituitary-Adrenal System - metabolism; Pituitary-Adrenal System - physiopathology; Psychiatry; Regression analysis; Regression models; Releasing; Restless legs syndrome; Sleep; Sleep disorders; Sleep Initiation and Maintenance Disorders - blood; Sleep Initiation and Maintenance Disorders - physiopathology; Studies; Thyroid; Thyroid gland; Thyroid Gland - metabolism; Thyroid Gland - physiopathology; Thyroid hormones; Thyroid-stimulating hormone; Thyrotropin - blood; Thyrotropin-releasing hormone; Thyrotropin-Releasing Hormone - blood; Thyroxine; Thyroxine - blood; Triiodothyronine; Triiodothyronine - blood; Womens health; China

The hypothalamus-pituitary-target gland axis is thought to be linked with insomnia, yet there has been a lack of further systematic studies to prove this. This study included 30 patients with primary insomnia (PI), 30 patients with depression-comorbid insomnia (DCI), and 30 healthy controls for expl...