Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study

• Published in: PloS one Vol. 18; no. 1; p. e0281070
• Main Authors: Jan, Asif, Zakiullah, Ali, Sajid, Muhammad, Basir, Arshad, Amina, Shah, Yasar, Bahadur, Haji, Khan, Hamayun, Khuda, Fazli, Akbar, Rani, Ijaz, Kiran
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.01.2023; Public Library of Science (PLoS)
• Subjects: Age; Analysis; Bioinformatics; Biology and Life Sciences; Care and treatment; Case-Control Studies; Developing countries; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diagnosis; Ethnicity; Ethylenediaminetetraacetic acid; Exome Sequencing; Gender; Genetic aspects; Genetic Predisposition to Disease; Genetic susceptibility; Genetic testing; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Genotype; Genotyping; Health risks; Hepatocyte nuclear factor 4; Humans; Insulin resistance; LDCs; Medicine and Health Sciences; Methods; Minority & ethnic groups; Pakistan; Patients; People and Places; Polymorphism, Single Nucleotide; Population studies; Research and Analysis Methods; Risk analysis; Risk factors; Single-nucleotide polymorphism; Statistical analysis; Statistical tests; Type 2 diabetes; Pakistan; Peshawar Pakistan; China; India

Genome-wide association studies have greatly increased the number of T2DM associated risk variants but most of them have focused on populations of European origin. There is scarcity of such studies in developing countries including Pakistan. High prevalence of T2DM in Pakistani population prompted u...