Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels

• Published in: PloS one Vol. 9; no. 1; p. e87119
• Main Authors: Howitt, Jason, Gysbers, Amanda M, Ayton, Scott, Carew-Jones, Francine, Putz, Ulrich, Finkelstein, David I, Halliday, Glenda M, Tan, Seong-Seng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.01.2014; Public Library of Science (PLoS)
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - genetics; alpha-Synuclein - metabolism; Animals; Astrocytes; Astrocytes - drug effects; Astrocytes - metabolism; Astrocytes - pathology; Basal ganglia; Biology; Brain research; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell activation; Central nervous system diseases; Disease control; Divalent metal transporter-1; Dopamine; Dopamine receptors; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Embryo, Mammalian; Ethics; Experiments; Female; Gene Expression Regulation; Humans; Ion Transport; Iron; Iron - metabolism; Iron - pharmacology; Iron transport; Laboratory animals; Ligases; Male; Medicine; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mental health; Mice; Mice, Knockout; Movement disorders; Neurodegenerative diseases; Neurons; Neuropathology; Neurosciences; Neurotoxicity; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Parkinsons disease; Pathogenesis; Post-translation; Primary Cell Culture; Protein expression; Protein transport; Proteins; Signal Transduction; Studies; Substantia nigra; Substantia Nigra - metabolism; Substantia Nigra - pathology; Synuclein; Transcription Factors - genetics; Transcription Factors - metabolism; Transport; Ubiquitin; Ubiquitin-protein ligase; Australia

Iron misregulation is a central component in the neuropathology of Parkinson's disease. The iron transport protein DMT1 is known to be increased in Parkinson's brains linking functional transport mechanisms with iron accumulation. The regulation of DMT1 is therefore critical to the managem...