Chronic Exposure to Androgenic-Anabolic Steroids Exacerbates Axonal Injury and Microgliosis in the CHIMERA Mouse Model of Repetitive Concussion

• Published in: PloS one Vol. 11; no. 1; p. e0146540
• Main Authors: Namjoshi, Dhananjay R., Cheng, Wai Hang, Carr, Michael, Martens, Kris M., Zareyan, Shahab, Wilkinson, Anna, McInnes, Kurt A., Cripton, Peter A., Wellington, Cheryl L.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.01.2016; Public Library of Science (PLoS)
• Subjects: Alzheimer's disease; Anabolic Agents - pharmacology; Anabolic steroids; Androgens - pharmacology; Animals; Athletes; Atrophy; Axons - drug effects; Axons - pathology; Behavior; Binding sites; Biomechanics; Body weight; Brain; Brain Concussion - complications; Brain Concussion - pathology; Brain Injuries - complications; Brain Injuries - pathology; Brain Injury, Chronic - complications; Brain Injury, Chronic - pathology; Chronic brain injury; Chronic exposure; Chronic traumatic encephalopathy; Cognitive ability; Collaboration; Complications and side effects; Concussion; Dementia; Disease Models, Animal; Disease Progression; Dosage and administration; Drugs; Encephalopathy; Exposure; Fuel consumption; Head injuries; Health aspects; Immune response; Innate immunity; Laboratories; Localization; Male; Medicine; Methyltestosterone; Methyltestosterone - pharmacology; Mice; Mice, Inbred C57BL; Nandrolone - pharmacology; Neurodegenerative diseases; Neuropathology; Neurosciences; Nortestosterone; Pathogenesis; Pathology; Proteins; Risk factors; Serotonin S1 receptors; Steroid hormones; Steroids; Steroids - pharmacology; Substance use; Substantia alba; Tau protein; Testosterone; Testosterone - analogs & derivatives; Testosterone - pharmacology; Time Factors; Traumatic brain injury; Young adults; Canada; United States > US

Concussion is a serious health concern. Concussion in athletes is of particular interest with respect to the relationship of concussion exposure to risk of chronic traumatic encephalopathy (CTE), a neurodegenerative condition associated with altered cognitive and psychiatric functions and profound t...