A Comprehensive Assessment of the Precision and Agreement of Anterior Corneal Power Measurements Obtained Using 8 Different Devices
To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the R...
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Published in | PloS one Vol. 7; no. 9; p. e45607 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
25.09.2012
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
ISSN | 1932-6203 1932-6203 |
DOI | 10.1371/journal.pone.0045607 |
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Abstract | To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.
Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA).
All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV<0.3%, ICC>0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ± 0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J(0) and J(45) was good, as the ICCs were higher than 0.9, except J(45) of Medmont and Pentacam. For the 95% LoAs of J(0) and J(45), they were all ≤ ± 0.31 among any two paired devices.
The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement.
ClinicalTrials.gov NCT01587287. |
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AbstractList | Purpose
To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.
Methods
Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA).
Results
All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV<0.3%, ICC>0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences ( P <0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ±0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J 0 and J 45 was good, as the ICCs were higher than 0.9, except J 45 of Medmont and Pentacam. For the 95% LoAs of J 0 and J 45 , they were all ≤ ±0.31 among any two paired devices.
Conclusions
The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement.
Trial Registration
ClinicalTrials.gov NCT01587287 To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA). All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ±0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J.sub.0 and J.sub.45 was good, as the ICCs were higher than 0.9, except J.sub.45 of Medmont and Pentacam. For the 95% LoAs of J.sub.0 and J.sub.45, they were all [less than or equal to] ±0.31 among any two paired devices. The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement. To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA).All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV<0.3%, ICC>0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ± 0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J(0) and J(45) was good, as the ICCs were higher than 0.9, except J(45) of Medmont and Pentacam. For the 95% LoAs of J(0) and J(45), they were all ≤ ± 0.31 among any two paired devices.The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement.ClinicalTrials.gov NCT01587287. Purpose To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Methods Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA). Results All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ±0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J.sub.0 and J.sub.45 was good, as the ICCs were higher than 0.9, except J.sub.45 of Medmont and Pentacam. For the 95% LoAs of J.sub.0 and J.sub.45, they were all [less than or equal to] ±0.31 among any two paired devices. Conclusions The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement. Trial Registration ClinicalTrials.gov NCT01587287 To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA). All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV<0.3%, ICC>0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ± 0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J(0) and J(45) was good, as the ICCs were higher than 0.9, except J(45) of Medmont and Pentacam. For the 95% LoAs of J(0) and J(45), they were all ≤ ± 0.31 among any two paired devices. The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement. ClinicalTrials.gov NCT01587287. Purpose To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Methods Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA). Results All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV<0.3%, ICC>0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ±0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J0 and J45 was good, as the ICCs were higher than 0.9, except J45 of Medmont and Pentacam. For the 95% LoAs of J0 and J45, they were all ≤ ±0.31 among any two paired devices. Conclusions The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement. Trial Registration ClinicalTrials.gov NCT01587287 To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.PURPOSETo comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.Thirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA).METHODSThirty-five eyes from 35 healthy subjects were included in the prospective study. In the first session, a single examiner performed on each subject randomly measurements with the RC-5000 (Tomey Corp., Japan), KR-8000 (Topcon, Japan), IOLMaster (Carl Zeiss Meditec, Germany), E300 (Medmont International, Australia), Allegro Topolyzer (Wavelight AG, Germany), Vista (EyeSys, TX), Pentacam (Oculus, Germany) and Sirius (CSO, Italy). Measurements were repeated in the second session (1 to 2 weeks later). Repeatability and reproducibility of corneal power measurements were assessed based on the intrasession and intersession within-subject standard deviation (Sw), repeatability (2.77Sw), coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was evaluated by 95% limits of agreement (LoA).All devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV<0.3%, ICC>0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ± 0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J(0) and J(45) was good, as the ICCs were higher than 0.9, except J(45) of Medmont and Pentacam. For the 95% LoAs of J(0) and J(45), they were all ≤ ± 0.31 among any two paired devices.RESULTSAll devices demonstrated high repeatability and reproducibility of the keratometric values (2.77Sw<0.36D, COV<0.3%, ICC>0.98). Repeated-measures analysis of variance with Bonferroni post test showed statistically significant differences (P<0.01) among mean keratometric values of most instruments; the largest differences were observed between the EyeSys Vista and Medmont E300. Good agreement (i.e., 95%LoA within ± 0.5D) was found between most instruments for flat, steep and mean keratometry, except for EyeSys and Medmont. Repeatability and reproducibility of vectors J(0) and J(45) was good, as the ICCs were higher than 0.9, except J(45) of Medmont and Pentacam. For the 95% LoAs of J(0) and J(45), they were all ≤ ± 0.31 among any two paired devices.The 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement.CONCLUSIONSThe 8 devices showed excellent repeatability and reproducibility. The results obtained using the RC-5000, KR-8000, IOLMaster, Allegro Topolyzer, Pentacam and Sirius were comparable, suggesting that they could be used interchangeably in most clinical settings. Caution is warranted with the measurements of the EyeSys Vista and Medmont E300, which should not be used interchangeably with other devices due to lower agreement.ClinicalTrials.gov NCT01587287.TRIAL REGISTRATIONClinicalTrials.gov NCT01587287. |
Audience | Academic |
Author | Feng, Yifan Hua, Yanjun Huang, Jinhai Savini, Giacomo Wen, Daizong Xu, Zhen Hoffer, Kenneth J. Yang, Feng Pan, Chao Wang, Qinmei |
AuthorAffiliation | 4 Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States of America 2 Key Laboratory of Vision Science, Ministry of Health P.R. China, Wenzhou, Zhejiang, China 5 Department of Ophthalmology, Eye Center, The 180th Hospital of People's Liberation Army, Quanzhou, Fujian, China 1 Department of Ophthalmology, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China 3 Department of Ophthalmology, G.B. Bietti Eye Foundation-IRCCS, Rome, Italy Medical University Graz, Austria |
AuthorAffiliation_xml | – name: 3 Department of Ophthalmology, G.B. Bietti Eye Foundation-IRCCS, Rome, Italy – name: 4 Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States of America – name: Medical University Graz, Austria – name: 5 Department of Ophthalmology, Eye Center, The 180th Hospital of People's Liberation Army, Quanzhou, Fujian, China – name: 1 Department of Ophthalmology, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China – name: 2 Key Laboratory of Vision Science, Ministry of Health P.R. China, Wenzhou, Zhejiang, China |
Author_xml | – sequence: 1 givenname: Qinmei surname: Wang fullname: Wang, Qinmei – sequence: 2 givenname: Giacomo surname: Savini fullname: Savini, Giacomo – sequence: 3 givenname: Kenneth J. surname: Hoffer fullname: Hoffer, Kenneth J. – sequence: 4 givenname: Zhen surname: Xu fullname: Xu, Zhen – sequence: 5 givenname: Yifan surname: Feng fullname: Feng, Yifan – sequence: 6 givenname: Daizong surname: Wen fullname: Wen, Daizong – sequence: 7 givenname: Yanjun surname: Hua fullname: Hua, Yanjun – sequence: 8 givenname: Feng surname: Yang fullname: Yang, Feng – sequence: 9 givenname: Chao surname: Pan fullname: Pan, Chao – sequence: 10 givenname: Jinhai surname: Huang fullname: Huang, Jinhai |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23049823$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Copyright | COPYRIGHT 2012 Public Library of Science Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2012 Wang et al 2012 Wang et al |
Copyright_xml | – notice: COPYRIGHT 2012 Public Library of Science – notice: Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2012 Wang et al 2012 Wang et al |
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DOI | 10.1371/journal.pone.0045607 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Conceived and designed the experiments: QMW GS KJH YFF DZW FY JHH. Performed the experiments: ZX YJH FY. Analyzed the data: QMW GS ZX DZW CP JHH. Contributed reagents/materials/analysis tools: QMW YFF YJH CP JHH. Wrote the paper: QMW GS KJH ZX JHH. Competing Interests: The authors have declared that no competing interests exist. |
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Snippet | To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.
Thirty-five eyes from 35 healthy... Purpose To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Methods Thirty-five eyes from... To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Thirty-five eyes from 35 healthy... To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.PURPOSETo comprehensively assess the... To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices.Thirty-five eyes from 35 healthy... Purpose To comprehensively assess the precision and agreement of anterior corneal power measurements using 8 different devices. Methods Thirty-five eyes from... |
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SubjectTerms | Accuracy Adult Automation Biometrics Cataracts Coefficient of variation Cornea Cornea - anatomy & histology Corneal Topography - instrumentation Corneal Topography - methods Corneal Topography - standards Correlation coefficient Correlation coefficients Devices Diagnostic equipment (Medical) Female Humans Laboratories Male Medical examination Medicine Optometry Power measurement Prospective Studies Reproducibility Reproducibility of Results Science Policy Software Statistical analysis Testing Tomography Topography Variance analysis |
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Title | A Comprehensive Assessment of the Precision and Agreement of Anterior Corneal Power Measurements Obtained Using 8 Different Devices |
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