Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN)

• Published in: PloS one Vol. 9; no. 6; p. e99006
• Main Authors: De Angelis, Maria, Montemurno, Eustacchio, Piccolo, Maria, Vannini, Lucia, Lauriero, Gabriella, Maranzano, Valentina, Gozzi, Giorgia, Serrazanetti, Diana, Dalfino, Giuseppe, Gobbetti, Marco, Gesualdo, Loreto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.06.2014; Public Library of Science (PLoS)
• Subjects: Adult; Amino acids; Analysis; Bacteria; Biology and Life Sciences; Biopsy; Case-Control Studies; Chromatography; Coding; Diabetes; Fecal microflora; Feces; Female; Food; Gas chromatography; Glomerulonephritis, IGA - microbiology; Humans; Immune system; Immunoglobulin A; Immunoglobulins; Kidney diseases; Male; Mass spectrometry; Mass spectroscopy; Media (selective); Medicine and Health Sciences; Metabolism; Metabolites; Metabolome; Metabolomics; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Middle Aged; Nephrology; Nephropathy; Pathogenesis; Patients; Rarefaction; RNA; Rodents; rRNA 16S; Selective media; Solid phase methods; Species; Statistical analysis; Statistical methods; Transplants & implants; Volatile compounds; Italy

This study aimed at investigating the fecal microbiota, and the fecal and urinary metabolome of non progressor (NP) and progressor (P) patients with immunoglobulin A nephropathy (IgAN). Three groups of volunteers were included in the study: (i) sixteen IgAN NP patients; (ii) sixteen IgAN P patients;...