Low Dose Influenza Virus Challenge in the Ferret Leads to Increased Virus Shedding and Greater Sensitivity to Oseltamivir

• Published in: PloS one Vol. 9; no. 4; p. e94090
• Main Authors: Marriott, Anthony C., Dove, Brian K., Whittaker, Catherine J., Bruce, Christine, Ryan, Kathryn A., Bean, Thomas J., Rayner, Emma, Pearson, Geoff, Taylor, Irene, Dowall, Stuart, Plank, Jenna, Newman, Edmund, Barclay, Wendy S., Dimmock, Nigel J., Easton, Andrew J., Hallis, Bassam, Silman, Nigel J., Carroll, Miles W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Animals; Antiviral Agents - therapeutic use; Antiviral drugs; Avian flu; Biology and Life Sciences; Disease Models, Animal; Distribution; Drug therapy; Exo-a-sialidase; Ferrets; Health aspects; Immune response; Immune system; Infections; Influenza; Influenza A Virus, H1N1 Subtype - immunology; Influenza vaccines; Influenza viruses; Innate immunity; Inoculation; Life sciences; Lungs; Medicine and Health Sciences; Mortality; Mustela putorius furo; Nose; Orthomyxoviridae Infections - drug therapy; Oseltamivir; Oseltamivir - therapeutic use; Oseltamivir phosphate; Pandemics; Pathogenesis; Public health; Reduction; Research and Analysis Methods; Respiratory diseases; Respiratory tract; Ribonucleic acid; RNA; Swine flu; Treatment Outcome; Vaccines; Virus Shedding; Viruses; United Kingdom; California; United Kingdom > UK

Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza interventions and vaccines. The 2009 pandemic influenza vi...