Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models

• Published in: PloS one Vol. 8; no. 9; p. e73085
• Main Authors: Tomio, Kensuke, Kawana, Kei, Taguchi, Ayumi, Isobe, Yosuke, Iwamoto, Ryo, Yamashita, Aki, Kojima, Satoko, Mori, Mayuyo, Nagamatsu, Takeshi, Arimoto, Takahide, Oda, Katsutoshi, Osuga, Yutaka, Taketani, Yuji, Kang, Jing X, Arai, Hiroyuki, Arita, Makoto, Kozuma, Shiro, Fujii, Tomoyuki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.09.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Animal models; Animal tissues; Animals; Arachidonate 12-lipoxygenase; Arachidonate 12-Lipoxygenase - genetics; Arachidonate 12-Lipoxygenase - metabolism; Arachidonate 15-Lipoxygenase - genetics; Arachidonate 15-Lipoxygenase - metabolism; Computational fluid dynamics; Cytokines; Disease Models, Animal; DNA microarrays; Eicosapentaenoic acid; Endometriosis; Endometriosis - genetics; Endometriosis - metabolism; Endometriosis - pathology; Endometrium; Fatty acids; Fatty Acids, Omega-3 - metabolism; Female; Gene Expression Profiling; Genetic engineering; Gynecology; Inflammation; Inflammatory bowel disease; Inoculation; Interleukin 6; Interleukin-6 - genetics; Interleukin-6 - metabolism; Interleukins; Lesions; Lipid Metabolism; Lipoxygenase; Liquid oxygen; Macrophages - metabolism; Medicine; Metabolites; Mice; Mice, Transgenic; Obstetrics; Omega 3 fatty acids; Omega 6 fatty acids; Oxidative stress; Pathogenesis; Peritoneal Diseases - metabolism; Peritoneal Diseases - pathology; Peritoneum; Pharmaceutical sciences; Polyunsaturated fatty acids; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Studies; Transgenic animals; Transgenic mice; Tumor necrosis factor-TNF; Unsaturated fatty acids; Womens health; United States > US; Japan; Massachusetts

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) play a role in controlling pathological inflammatory reactions. Endometriosis is characterized by the presence of endometrial tissue on the peritoneum and an exaggerated inflammatory environment around ectopic tissues. Here peritoneal endometriosis...