Optimizing Exchange Transfusion for Severe Unconjugated Hyperbilirubinemia: Studies in the Gunn Rat
Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of...
Saved in:
| Published in | PloS one Vol. 8; no. 10; p. e77179 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
15.10.2013
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0077179 |
Cover
| Abstract | Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration.
To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration.
Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ≈ 20 min. PT (18 µW/cm(2)/nm) was started after ET or at T0. Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined.
We performed ET in 21 Gunn rats with 100% survival. At T1, ET was profoundly more effective in decreasing both UCB -44%, p<0.01) and Bf -81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (-54% compared to ET).
We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. |
|---|---|
| AbstractList | Background
Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration.
Aim
To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration.
Methods
Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ∼20 min. PT (18 µW/cm 2 /nm) was started after ET or at T 0 . Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined.
Results
We performed ET in 21 Gunn rats with 100% survival. At T 1 , ET was profoundly more effective in decreasing both UCB −44%, p<0.01) and Bf −81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (−54% compared to ET).
Conclusions
We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. Background Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration. Aim To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration. Methods Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ~20 min. PT (18 [micro]W/cm.sup.2 /nm) was started after ET or at T.sub.0 . Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined. Results We performed ET in 21 Gunn rats with 100% survival. At T.sub.1, ET was profoundly more effective in decreasing both UCB -44%, p<0.01) and Bf -81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (-54% compared to ET). Conclusions We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration. To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration. Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ~20 min. PT (18 [micro]W/cm.sup.2 /nm) was started after ET or at T.sub.0 . Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined. We performed ET in 21 Gunn rats with 100% survival. At T.sub.1, ET was profoundly more effective in decreasing both UCB -44%, p<0.01) and Bf -81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (-54% compared to ET). We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration.BACKGROUNDSevere unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration.To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration.AIMTo establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration.Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ≈ 20 min. PT (18 µW/cm(2)/nm) was started after ET or at T0. Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined.METHODSGunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ≈ 20 min. PT (18 µW/cm(2)/nm) was started after ET or at T0. Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined.We performed ET in 21 Gunn rats with 100% survival. At T1, ET was profoundly more effective in decreasing both UCB -44%, p<0.01) and Bf -81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (-54% compared to ET).RESULTSWe performed ET in 21 Gunn rats with 100% survival. At T1, ET was profoundly more effective in decreasing both UCB -44%, p<0.01) and Bf -81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (-54% compared to ET).We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation.CONCLUSIONSWe optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. BACKGROUND: Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration. AIM: To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration. METHODS: Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ≈ 20 min. PT (18 µW/cm(2)/nm) was started after ET or at T0. Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined. RESULTS: We performed ET in 21 Gunn rats with 100% survival. At T1, ET was profoundly more effective in decreasing both UCB -44%, p<0.01) and Bf -81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (-54% compared to ET). CONCLUSIONS: We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. Background Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration. Aim To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration. Methods Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ∼20 min. PT (18 µW/cm2/nm) was started after ET or at T0. Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined. Results We performed ET in 21 Gunn rats with 100% survival. At T1, ET was profoundly more effective in decreasing both UCB −44%, p<0.01) and Bf −81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (−54% compared to ET). Conclusions We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of unconjugated hyperbilirubinemia. Studies to improve ET efficacy have been hampered by the low application of ET in humans and by the lack of an in vivo model. The absence of an appropriate animal model has also prevented to determine the efficacy of adjunct or alternative treatment options such as albumin (Alb) administration. To establish an in vivo model for ET and to determine the most effective treatment (combination) of ET, PT and Alb administration. Gunn rats received either PT, PT+Alb, ET, ET+PT, ET+PT+Alb or sham operation (each n = 7). ET was performed via the right jugular vein in ≈ 20 min. PT (18 µW/cm(2)/nm) was started after ET or at T0. Albumin i.p. injections (2.5 g/kg) were given after ET or before starting PT. Plasma unconjugated bilirubin (UCB), plasma free bilirubin (Bf), and brain bilirubin concentrations were determined. We performed ET in 21 Gunn rats with 100% survival. At T1, ET was profoundly more effective in decreasing both UCB -44%, p<0.01) and Bf -81%, p<0.05) than either PT or PT+Alb. After 48 h, the combination of ET+PT+Alb showed the strongest hypobilirubinemic effect (-54% compared to ET). We optimized ET for severe unconjugated hyperbilirubinemia in the Gunn rat model. Our data indicate that ET is the most effective treatment option, in the acute as well as the follow-up situation. |
| Audience | Academic |
| Author | Schreuder, Andrea B. Vitek, Libor Havinga, Rick Hulzebos, Christian V. Ahlfors, Charles E. Vanikova, Jana Verkade, Henkjan J. |
| AuthorAffiliation | 34 4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic 4 Stanford University, School of Medicine, Stanford, California, United States of America 5 Neonatology, Department of Pediatrics, Beatrix Children’s Hospital - University Medical Center Groningen, Groningen, The Netherlands 2 Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic 1 Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, Beatrix Children’s Hospital - University Medical Center Groningen, University of Groningen, Groningen, The Netherlands University of North Carolina School of Medicine, United States of America |
| AuthorAffiliation_xml | – name: 4 Stanford University, School of Medicine, Stanford, California, United States of America – name: 5 Neonatology, Department of Pediatrics, Beatrix Children’s Hospital - University Medical Center Groningen, Groningen, The Netherlands – name: University of North Carolina School of Medicine, United States of America – name: 2 Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic – name: 34 4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic – name: 1 Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, Beatrix Children’s Hospital - University Medical Center Groningen, University of Groningen, Groningen, The Netherlands |
| Author_xml | – sequence: 1 givenname: Andrea B. surname: Schreuder fullname: Schreuder, Andrea B. – sequence: 2 givenname: Jana surname: Vanikova fullname: Vanikova, Jana – sequence: 3 givenname: Libor surname: Vitek fullname: Vitek, Libor – sequence: 4 givenname: Rick surname: Havinga fullname: Havinga, Rick – sequence: 5 givenname: Charles E. surname: Ahlfors fullname: Ahlfors, Charles E. – sequence: 6 givenname: Christian V. surname: Hulzebos fullname: Hulzebos, Christian V. – sequence: 7 givenname: Henkjan J. surname: Verkade fullname: Verkade, Henkjan J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24143211$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk11r2zAUhs3oWD-2fzA2w2BsF8kkS5asXgxK6dpAIdC0uxWyLDkKjpRKcmn366c0bklKGbMuLI6e8x7plc5htmedVVn2EYIxRBT-WLjeW9GNVyk8BoBSSNmb7AAyVIxIAdDe1nw_OwxhAUCJKkLeZfsFhhgVEB5kcrqKZmn-GNvmZ_dyLmyr8msvbNB9MM7m2vl8pu6UV_mNlc4u-lZE1eQXDyvla9MZ39fGqqURx_ks9o1RITc2j3OVn_fW5lcivs_eatEF9WH4H2U3v86uTy9Gl9PzyenJ5UgSVsQRLEiDCCVYl6qirGYSEwB1IVldKEFEwSgVFcaQUE0BqGsiag2RrmiZPqXRUfZ5o7vqXOCDP4FDjIu1E2WRiMmGaJxY8JU3S-EfuBOGPwacb7nw0chOcUa0TFUrigTCJWAMIMaa9T4QkBJUSevnUK2vl6qRykYvuh3R3RVr5rx1dxxRRiEASeDbIODdba9C5EsTpOo6YZXrH_eNEQMQ4YR-eYG-frqBakU6gLHapbpyLcpPMK2KsioJTNT4FSqNJl1iumClTYrvJHzfSUhMVPexFX0IfDK7-n92-nuX_brFzpXo4jy4ro_p2YVd8NO2088WP73iBOANIL0LwSv9jEDA183yZBdfNwsfmiWlHb9IkyaKdfnkiOn-nfwX9OMZyg |
| CitedBy_id | crossref_primary_10_1021_acsanm_2c04461 crossref_primary_10_1038_s41390_022_02351_x crossref_primary_10_1016_j_clp_2016_01_011 crossref_primary_10_1038_s41390_019_0570_x crossref_primary_10_1038_s41390_021_01546_y crossref_primary_10_1063_5_0066073 |
| Cites_doi | 10.1097/00005072-198401000-00004 10.1172/JCI106541 10.1620/tjem.157.31 10.1111/j.1651-2227.1974.tb04796.x 10.1016/0026-2862(87)90050-1 10.1038/jp.2008.199 10.1016/j.cca.2005.07.030 10.1542/peds.30.4.613 10.1128/AAC.26.6.903 10.1016/j.jhep.2012.08.011 10.1016/0883-2897(91)90120-A 10.1038/sj.jp.7210642 10.1016/j.jpeds.2004.01.054 10.1016/S0022-3476(76)80020-0 10.1097/01.CCM.0000150655.75519.02 10.1542/peds.2005-0395 10.1542/peds.99.5.e7 10.1016/j.jchromb.2008.03.005 10.1038/pr.2012.23 10.1046/j.1525-1594.1998.06166.x 10.1203/PDR.0b013e3181568c94 10.1074/jbc.274.16.10852 10.1542/peds.70.1.43 10.1203/00006450-197110000-00007 10.1001/archpedi.1961.04020040050007 10.1172/JCI105383 10.1542/peds.2006-2910 10.1056/NEJM200102223440807 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2013 Public Library of Science 2013 Schreuder et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Schreuder et al 2013 Schreuder et al |
| Copyright_xml | – notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Schreuder et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2013 Schreuder et al 2013 Schreuder et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0077179 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Agricultural Science Database MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine |
| DocumentTitleAlternate | A Rat Model for Exchange Transfusion |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1442193252 oai_doaj_org_article_96fcea6873a3450990399dea6a30cc08 PMC3797100 3099728451 A478258561 24143211 10_1371_journal_pone_0077179 |
| Genre | Journal Article |
| GeographicLocations | Czech Republic Netherlands |
| GeographicLocations_xml | – name: Netherlands – name: Czech Republic |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM BBORY CGR CUY CVF ECM EIF NPM PV9 RZL PMFND 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS RC3 7X8 ESTFP PUEGO 5PM AAPBV ABPTK N95 |
| ID | FETCH-LOGICAL-c692t-126d36764f5e879b9c4601f2c9b2ea6a2977a844167f700bb6abf13f875555ef3 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Sun Aug 06 00:16:07 EDT 2023 Wed Aug 27 01:24:30 EDT 2025 Thu Aug 21 18:34:40 EDT 2025 Mon Sep 08 15:58:08 EDT 2025 Fri Jul 25 10:21:36 EDT 2025 Tue Jun 17 21:27:22 EDT 2025 Tue Jun 10 20:27:29 EDT 2025 Fri Jun 27 04:57:52 EDT 2025 Fri Jun 27 03:45:57 EDT 2025 Thu May 22 21:21:39 EDT 2025 Thu Apr 03 06:55:47 EDT 2025 Tue Jul 01 01:35:22 EDT 2025 Thu Apr 24 23:05:12 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-126d36764f5e879b9c4601f2c9b2ea6a2977a844167f700bb6abf13f875555ef3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: ABS HJV. Performed the experiments: ABS RH. Analyzed the data: ABS JV LV. Contributed reagents/materials/analysis tools: LV CEA. Wrote the paper: ABS LV CEA CVH HJV. Competing Interests: The authors have declared that no competing interests exist. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0077179 |
| PMID | 24143211 |
| PQID | 1442193252 |
| PQPubID | 1436336 |
| PageCount | e77179 |
| ParticipantIDs | plos_journals_1442193252 doaj_primary_oai_doaj_org_article_96fcea6873a3450990399dea6a30cc08 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3797100 proquest_miscellaneous_1444390134 proquest_journals_1442193252 gale_infotracmisc_A478258561 gale_infotracacademiconefile_A478258561 gale_incontextgauss_ISR_A478258561 gale_incontextgauss_IOV_A478258561 gale_healthsolutions_A478258561 pubmed_primary_24143211 crossref_primary_10_1371_journal_pone_0077179 crossref_citationtrail_10_1371_journal_pone_0077179 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-10-15 |
| PublicationDateYYYYMMDD | 2013-10-15 |
| PublicationDate_xml | – month: 10 year: 2013 text: 2013-10-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2013 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | NJ Raat (ref31) 2005; 33 PA Dennery (ref20) 2001; 344 S Eguchi (ref25) 1998; 22 J Kurantsin-Mills (ref29) 1987; 34 ref30 L Johnson (ref13) 1961; 101 JC Jackson (ref6) 1997; 99 LA Steiner (ref21) 2007; 120 M Ahdab-Barmada (ref16) 1984; 43 CE Ahlfors (ref18) 2006; 365 RP Wennberg (ref5) 2006; 117 K Patra (ref7) 2004; 144 L Johnson (ref12) 1959; 97 GR Hodges (ref28) 1984; 26 K Takeda (ref27) 1989; 157 I Diamond (ref1) 1966; 45 WJ Keenan (ref8) 1985; 75 S Gazzin (ref15) 2012; 71 J Zelenka (ref19) 2008; 867 G Chan (ref23) 1976; 88 CA Henry (ref26) 1991; 18 A Livaditis (ref10) 1974; 63 JD Ostrow (ref17) 1971; 50 SD Zucker (ref4) 1999; 274 GB Odell (ref24) 1962; 30 SD Calligaris (ref2) 2007; 62 OG Strebel L (ref14) 1971; 5 M Maisels (ref22) 2001; 21 ref3 BA Lauer (ref9) 1982; 70 FJ Cuperus (ref11) 2013; 58 9790082 - Artif Organs. 1998 Oct;22(10):847-53 13790309 - Am J Dis Child. 1961 Mar;101:322-49 19242487 - J Perinatol. 2009 Apr;29(4):305-9 11803426 - J Perinatol. 2001 Dec;21 Suppl 1:S93-7; discussion S104-7 16168977 - Clin Chim Acta. 2006 Mar;365(1-2):78-85 18373963 - J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):37-42 3670112 - Microvasc Res. 1987 Sep;34(2):152-67 17606558 - Pediatrics. 2007 Jul;120(1):27-32 13649090 - AMA J Dis Child. 1959 May;97(5, Part 1):591-608 6693927 - J Neuropathol Exp Neurol. 1984 Jan;43(1):45-56 1255322 - J Pediatr. 1976 Apr;88(4 Pt 1):609-13 5949114 - J Clin Invest. 1966 May;45(5):678-89 3969351 - Pediatrics. 1985 Feb;75(2 Pt 2):417-21 11207355 - N Engl J Med. 2001 Feb 22;344(8):581-90 1917528 - Int J Rad Appl Instrum B. 1991;18(5):565-7 5545128 - J Clin Invest. 1971 Mar;50(3):707-18 15644646 - Crit Care Med. 2005 Jan;33(1):39-45; discussion 238-9 9113964 - Pediatrics. 1997 May;99(5):E7 6806770 - Pediatrics. 1982 Jul;70(1):43-7 22337225 - Pediatr Res. 2012 Jun;71(6):653-60 15126997 - J Pediatr. 2004 May;144(5):626-31 16452368 - Pediatrics. 2006 Feb;117(2):474-85 13939465 - Pediatrics. 1962 Oct;30:613-21 18049372 - Pediatr Res. 2007 Nov;62(5):576-80 22922094 - J Hepatol. 2013 Jan;58(1):134-40 6524905 - Antimicrob Agents Chemother. 1984 Dec;26(6):903-8 2469134 - Tohoku J Exp Med. 1989 Jan;157(1):31-7 4820593 - Acta Paediatr Scand. 1974 Mar;63(2):277-82 10196162 - J Biol Chem. 1999 Apr 16;274(16):10852-62 |
| References_xml | – volume: 43 start-page: 45 year: 1984 ident: ref16 article-title: The neuropathology of kernicterus in the premature neonate: Diagnostic problems publication-title: J Neuropathol Exp Neurol doi: 10.1097/00005072-198401000-00004 – volume: 50 start-page: 707 year: 1971 ident: ref17 article-title: Photocatabolism of labeled bilirubin in the congenitally jaundiced (gunn) rat publication-title: J Clin Invest doi: 10.1172/JCI106541 – volume: 157 start-page: 31 year: 1989 ident: ref27 article-title: Effect of blood exchange transfusion as an initial treatment of acute hemorrhagic pancreatitis publication-title: Tohoku J Exp Med doi: 10.1620/tjem.157.31 – volume: 63 start-page: 277 year: 1974 ident: ref10 article-title: Necrotizing enterocolitis after catheterization of the umbilical vessels publication-title: Acta Paediatr Scand doi: 10.1111/j.1651-2227.1974.tb04796.x – volume: 34 start-page: 152 year: 1987 ident: ref29 article-title: Flow dynamics of human sickle erythrocytes in the mesenteric microcirculation of the exchange-transfused rat publication-title: Microvasc Res doi: 10.1016/0026-2862(87)90050-1 – ident: ref3 doi: 10.1038/jp.2008.199 – volume: 365 start-page: 78 year: 2006 ident: ref18 article-title: Measurement of unbound bilirubin by the peroxidase test using zone fluidics publication-title: Clin Chim Acta doi: 10.1016/j.cca.2005.07.030 – volume: 30 start-page: 613 year: 1962 ident: ref24 article-title: Administration of albumin in the management of hyperbilirubinemia by exchange transfusions publication-title: Pediatrics doi: 10.1542/peds.30.4.613 – volume: 26 start-page: 903 year: 1984 ident: ref28 article-title: Effect of exchange transfusion with an oxygen-carrying resuscitation fluid on the efficacy of penicillin therapy of pneumococcal infection in rats publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.26.6.903 – volume: 58 start-page: 134 year: 2013 ident: ref11 article-title: Beyond plasma bilirubin: The effects of phototherapy and albumin on brain bilirubin levels in gunn rats publication-title: J Hepatol doi: 10.1016/j.jhep.2012.08.011 – volume: 97 start-page: 591 year: 1959 ident: ref12 article-title: Kernicterus in rats with an inherited deficiency of glucuronyl transferase publication-title: AMA J Dis Child – volume: 18 start-page: 565 year: 1991 ident: ref26 article-title: Improved monoclonal antibody tumor/background ratios with exchange transfusions publication-title: Int J Rad Appl Instrum B doi: 10.1016/0883-2897(91)90120-A – volume: 21 start-page: S93 year: 2001 ident: ref22 article-title: Phototherapy - traditional and nontraditional publication-title: Journal of perinatology doi: 10.1038/sj.jp.7210642 – volume: 144 start-page: 626 year: 2004 ident: ref7 article-title: Adverse events associated with neonatal exchange transfusion in the 1990s publication-title: J Pediatr doi: 10.1016/j.jpeds.2004.01.054 – ident: ref30 – volume: 88 start-page: 609 year: 1976 ident: ref23 article-title: Variance in albumin loading in exchange transfusions publication-title: J Pediatr doi: 10.1016/S0022-3476(76)80020-0 – volume: 33 start-page: 39 year: 2005 ident: ref31 article-title: The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model publication-title: Crit Care Med doi: 10.1097/01.CCM.0000150655.75519.02 – volume: 117 start-page: 474 year: 2006 ident: ref5 article-title: Toward understanding kernicterus: A challenge to improve the management of jaundiced newborns publication-title: Pediatrics doi: 10.1542/peds.2005-0395 – volume: 99 start-page: E7 year: 1997 ident: ref6 article-title: Adverse events associated with exchange transfusion in healthy and ill newborns publication-title: Pediatrics doi: 10.1542/peds.99.5.e7 – volume: 867 start-page: 37 year: 2008 ident: ref19 article-title: Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues publication-title: J Chromatogr B Analyt Technol Biomed Life Sci doi: 10.1016/j.jchromb.2008.03.005 – volume: 75 start-page: 417 year: 1985 ident: ref8 article-title: Morbidity and mortality associated with exchange transfusion publication-title: Pediatrics – volume: 71 start-page: 653 year: 2012 ident: ref15 article-title: Bilirubin accumulation and cyp mRNA expression in selected brain regions of jaundiced gunn rat pups publication-title: Pediatr Res doi: 10.1038/pr.2012.23 – volume: 22 start-page: 847 year: 1998 ident: ref25 article-title: Total blood exchange suppresses the early stage of liver regeneration following partial hepatectomy in rats publication-title: Artif Organs doi: 10.1046/j.1525-1594.1998.06166.x – volume: 62 start-page: 576 year: 2007 ident: ref2 article-title: Cytotoxicity is predicted by unbound and not total bilirubin concentration publication-title: Pediatr Res doi: 10.1203/PDR.0b013e3181568c94 – volume: 274 start-page: 10852 year: 1999 ident: ref4 article-title: Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes publication-title: J Biol Chem doi: 10.1074/jbc.274.16.10852 – volume: 70 start-page: 43 year: 1982 ident: ref9 article-title: Probable graft-vs-graft reaction in an infant after exchange transfusion and marrow transplantation publication-title: Pediatrics doi: 10.1542/peds.70.1.43 – volume: 5 start-page: 548 year: 1971 ident: ref14 article-title: Bilirubin uridine diphosphoglucuronyltransferase in rat liver microsomes: Genetic variation and maturation publication-title: Pediatr Res doi: 10.1203/00006450-197110000-00007 – volume: 101 start-page: 322 year: 1961 ident: ref13 article-title: Kernicterus in rats lacking glucuronyl transferase. II. factors which alter bilirubin concentration and frequency of kernicterus publication-title: Am J Dis Child doi: 10.1001/archpedi.1961.04020040050007 – volume: 45 start-page: 678 year: 1966 ident: ref1 article-title: Experimental bilirubin encephalopathy. the mode of entry of bilirubin-14C into the central nervous system publication-title: J Clin Invest doi: 10.1172/JCI105383 – volume: 120 start-page: 27 year: 2007 ident: ref21 article-title: A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality publication-title: Pediatrics doi: 10.1542/peds.2006-2910 – volume: 344 start-page: 581 year: 2001 ident: ref20 article-title: Neonatal hyperbilirubinemia publication-title: N Engl J Med doi: 10.1056/NEJM200102223440807 – reference: 16452368 - Pediatrics. 2006 Feb;117(2):474-85 – reference: 22337225 - Pediatr Res. 2012 Jun;71(6):653-60 – reference: 13939465 - Pediatrics. 1962 Oct;30:613-21 – reference: 1917528 - Int J Rad Appl Instrum B. 1991;18(5):565-7 – reference: 17606558 - Pediatrics. 2007 Jul;120(1):27-32 – reference: 19242487 - J Perinatol. 2009 Apr;29(4):305-9 – reference: 11207355 - N Engl J Med. 2001 Feb 22;344(8):581-90 – reference: 2469134 - Tohoku J Exp Med. 1989 Jan;157(1):31-7 – reference: 9113964 - Pediatrics. 1997 May;99(5):E7 – reference: 11803426 - J Perinatol. 2001 Dec;21 Suppl 1:S93-7; discussion S104-7 – reference: 15644646 - Crit Care Med. 2005 Jan;33(1):39-45; discussion 238-9 – reference: 1255322 - J Pediatr. 1976 Apr;88(4 Pt 1):609-13 – reference: 18049372 - Pediatr Res. 2007 Nov;62(5):576-80 – reference: 6693927 - J Neuropathol Exp Neurol. 1984 Jan;43(1):45-56 – reference: 4820593 - Acta Paediatr Scand. 1974 Mar;63(2):277-82 – reference: 13649090 - AMA J Dis Child. 1959 May;97(5, Part 1):591-608 – reference: 22922094 - J Hepatol. 2013 Jan;58(1):134-40 – reference: 6524905 - Antimicrob Agents Chemother. 1984 Dec;26(6):903-8 – reference: 6806770 - Pediatrics. 1982 Jul;70(1):43-7 – reference: 3670112 - Microvasc Res. 1987 Sep;34(2):152-67 – reference: 15126997 - J Pediatr. 2004 May;144(5):626-31 – reference: 10196162 - J Biol Chem. 1999 Apr 16;274(16):10852-62 – reference: 9790082 - Artif Organs. 1998 Oct;22(10):847-53 – reference: 5545128 - J Clin Invest. 1971 Mar;50(3):707-18 – reference: 3969351 - Pediatrics. 1985 Feb;75(2 Pt 2):417-21 – reference: 5949114 - J Clin Invest. 1966 May;45(5):678-89 – reference: 13790309 - Am J Dis Child. 1961 Mar;101:322-49 – reference: 18373963 - J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):37-42 – reference: 16168977 - Clin Chim Acta. 2006 Mar;365(1-2):78-85 |
| SSID | ssj0053866 |
| Score | 2.1252637 |
| Snippet | Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the treatment of... Background Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the... BACKGROUND: Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the... Background Severe unconjugated hyperbilirubinemia carries the risk of neurotoxicity. Phototherapy (PT) and exchange transfusion (ET) are cornerstones in the... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e77179 |
| SubjectTerms | Albumin Animal models Animals Bilirubin Bilirubin - blood Bilirubin - metabolism Biochemistry Brain Brain - metabolism Brain damage Data processing Exchange Transfusion, Whole Blood - methods Gastroenterology Hepatology Hospitals Humans Hyperbilirubinemia Hyperbilirubinemia - blood Hyperbilirubinemia - metabolism Hyperbilirubinemia - therapy In vivo methods and tests Jaundice Jugular vein Laboratories Light therapy Liver Male Medicine Metabolic disorders Mortality Neurotoxicity Newborn babies Pediatrics Phototherapy Rats Rats, Gunn Studies Time Factors Transfusion Veins & arteries |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyqsLbTEICTiEJn4l5lYQpSBBJaCot8hxbLqoTVabjYT49czE3qhBlcqBPewhnmw2M2PPN8nMZ0KeGcdlLTk4r2MqEY65REuTJb4yTnsvRVZjo_Cnz-roRHw8laeXtvrCmrBADxwUt6-Vt86oIueGC4mvcSCk1nDE8NTa0Oab6nSTTIU1GGaxUrFRjufZfrTLq2XbOCTLhhxGTwLRwNc_rsqz5XnbXQU5_66cvBSKDm-TWxFD0oPw37fIDdfcIVtxlnb0RaSSfnmX2GNYES4WvyE-UfcrNPnS9YBVe3xMRgGyUoiNbuUoBLi2-dnjY7WankF6usK62VUPqbO7WJjXtAslh3TRUECN9D1AXwr-c4-cHL779vYoidsqJFZptk4ypmrkaRNeuiLXlbYCsjLPrK4Y6pUBJDQFwCSV-zxNq0qZymfcQ2YDH-f5fTJrQJHbhNbGGi1AJDVeqDrVzBXMSFdnhUvhe074RseljZzjuPXFeTm8SMsh9wgqK9EyZbTMnCTjWcvAuXGN_Bs03yiLjNnDAfCjMvpReZ0fzcljNH4Z2k_HeV8eCMBQkFMpuJmngwSyZjRYlvPD9F1Xfjj-_g9CX79MhJ5HId-COqyJrRBwT8jGNZHcmUjC3LeT4W101Y1WOkjkBENILhmcuXHfq4efjMP4o1hq17i2H2QEPgjjYk4eBG8fNQtwT3CWwXXzyTyYqH460izOBtJynmskknr4P2z1iNxkuCsJFhbJHTJbr3q3C9hwXe0Ny8AfHPxkPA priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELagSIgXxMaPdRtgEBLwEJbYjhPzggZaV5DGpI2ivUWOY4-iLSlNIyH-eu4SNxA0AX3oQ31p6_Pd-Tv7_JmQZ9ryuIg5GK9lMhCW2UDFOgpcrq1yLhZRgQeFjz7K6Ux8OIvP_IJb7csq1zGxDdRFZXCNfA-AP0OwEbM3i28B3hqFu6v-Co3r5EYEMw3aeTo5XEdi8GUp_XE5nkR7fnReLarSImU2ZDJqMB21rP19bB4tLqr6KuD5Z_3kbxPS5A657ZEk3e-GfoNcs-UmuXnk98o3yYZ325q-8NzSL-8Scwwh4nL-AyYsevC9O_VL2_nKNbhuRgHD0lML9m3prIRc-WuD62wFnUK-usRC2mUDubS9nOvX1Ncg0nlJAUbSQ8DC9ESv7pHZ5ODTu2ng71kIjFRsFYDqCiRuEy62aaJyZQSkaY4ZlTOrpWaAEXUKuEkmLgnDPJc6dxF3kOrAyzp-n4xK0OkWoYU2WgkQCbUTsggVsynTsS2i1IbwPiZ8re7MeBJyvAvjImt31hJIRjrtZThImR-kMQn6pxYdCcc_5N_iSPaySKHdflAtzzPvkZmSzkDv0oRrLmLcHwSsVmB_eWhMmI7JY7SDrDuP2geCbF8AqIIkS0JnnrYSSKNRYp3OuW7qOnt__Pk_hE5PBkLPvZCrQB1G-7MR0Cek5xpI7g4kIRiYQfMWWu1aK3X2y23gybUlX938pG_GL8Xau9JWTSsjcGWMizF50Bl-r1nAf4KzCH43GbjEQPXDlnL-pWUx54lCZqntv_-tHXKL4QUkWEMU75LRatnYhwADV_mj1td_ArlpXjM priority: 102 providerName: ProQuest |
| Title | Optimizing Exchange Transfusion for Severe Unconjugated Hyperbilirubinemia: Studies in the Gunn Rat |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24143211 https://www.proquest.com/docview/1442193252 https://www.proquest.com/docview/1444390134 https://pubmed.ncbi.nlm.nih.gov/PMC3797100 https://doaj.org/article/96fcea6873a3450990399dea6a30cc08 http://dx.doi.org/10.1371/journal.pone.0077179 |
| Volume | 8 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELe27oUXxPhaYBSDkICHTInjOAkSQtu0biBtQ4OivkVOYm9FXVKSRhr89dwlTkRQJ-iDH-pzJJ_vfL-zz3eEvJLK8zPfA-FVTNhcMWVHvnRtnUgVae1zN8OHwqdn4mTKP8382QbparYaBlZrXTusJzUtF3s3P35-AIV_31RtCNxu0N6yyBWmwgYPJdokW2CbBLpjp7y_VwDtFsI8oLttJKYH5oAimOsObFWT0r_fuEfLRVGtQ6V_B1f-Ya0m98hdAzPpfisX22RD5ffJtlHkir4x2abfPiDpOWwa1_NfYMKoumnfAdNVA2drPEmjgGopmE9VKgo2sMi_13jyltEr8GBLDK0ta_Cu1fVcvqNVG5VI5zkFYEmPAR1TELGHZDo5-np4YpvKC3YqIrayXSYyTOXGta_CIEqilIPjplkaJUxJIRmgRhlyZLAOHCdJhEy062lwfuCntPeIjHLg6Q6hmUxlxIHEkZqLzImYCpn0VeaGyoHWIl7H4zg1acmxOsYibu7aAnBPWpbFuEixWSSL2P2oZZuW4x_0B7h8PS0m1W7-KMrL2OhoHAmdwuzCwJMe9_HGENBbhvP1nDR1Qos8x8WP2xeq_dYQ73OAWeB2CZjMy4YCE2vkGLlzKeuqij-ef_sPoi8XA6LXhkgXwI5UmtcSMCdM2DWg3B1QwvaQDrp3UFQ7rlTg63GGqN1nMLIT3_XdL_pu_ChG4-WqqBsajmdlHrfI41bae852umORYKAHA9YPe_L5VZPX3AsizDX15NZvPiV3GFYjwYAif5eMVmWtngEmXCVjshnMAmjDQxfbyfGYbB0cnX2-GDenLONmG_gNsKBmrw |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbKIgEXRMujC4UaBAIOoYnjvJAQKtCyS7ut1HbR3oLj2GVRmyybjXj8KH4jM4kTCKqAS3PYQzxJ1uPx-Bt7HoQ8FMr1Us8F4VXMt7hiyoo84Vg6ESrS2uNOioHCoz1_MObvJt5kifxoYmHQrbLRiZWiTnOJe-QbAPwZgg2PvZx9trBqFJ6uNiU0arHYUd--gMlWvBi-gfF9xNj21tHrgWWqCljSj9jCcpifYpoyrj0VBlESSQ5GiWYySpgSvmCAiEQIKMEPdGDbSeKLRDuuBmAPl9IuvPcCuchxZxzmTzBpDTzQHb5vwvPcwNkw0vBslmcKU3SD5RR1lr-qSkC7FvRmJ3lxFtD901_ztwVw-xq5apAr3axFbZksqWyFXBqZs_kVsmzUREGfmFzWT68TuQ8q6XT6HRZIuvW1jjKm1fqoS9yno4CZ6aGC-aToOAPb_FOJ-3opHYB9PEfH3XkJtrs6nYrn1Pg80mlGAbbSt4C96YFY3CDjcxmBm6SXAU9XCU2FFBEHElto7qd2xFTIhKdSJ1Q2_PaJ27A7libpOdbeOImrk7wAjJ-aezEOUmwGqU-s9qlZnfTjH_SvcCRbWkzZXd3I58ex0QBx5GsJvQsDV7jcw_NIwIYp9te1pbTDPllHOYjr-NdW8cSbHEAcGHU-dOZBRYFpOzL0CzoWZVHEw_33_0F0eNAhemyIdA7skMLEYkCfMB1Yh3KtQwnKR3aaV1FqG64U8a9pCk82knx28_22GV-Kvn6ZysuKhuNOnMv75FYt-C1nAW9ylznw3aAzJTqs77Zk049V1nQ3iDCT1e2__611cnlwNNqNd4d7O3fIFYbFT9B_yVsjvcW8VHcBgi6Se9W8p-TDeSuan3G4me4 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdGkSZeEBsfKwxmEAh4CE3sfCIhNNhKx9iGNor6FhzHHkVbUppGfPxp_HXcJU4gaAJe1oc-1Je2Pt-df2ffByH3heJe6nEQXsV8y1VMWZEnHEsnQkVae66TYqLw3r4_GruvJ95kifxocmEwrLKxiZWhTnOJZ-QDAP4MwYbHBtqERbzdGj6ffbawgxTetDbtNGoR2VXfvoD7Vjzb2YK1fsDYcPvdy5FlOgxY0o_YwnKYn2LJMld7KgyiJJIuOCiayShhSviCAToSISAGP9CBbSeJLxLtcA0gH15Kc_jeC-RiwAFVgS4Fk9bZAzvi-yZVjwfOwEjGk1meKSzXDV5U1NkKq44B7b7Qm53kxVmg98_Yzd82w-EVctmgWLpZi90KWVLZKlneM_f0q2TFmIyCPjJ1rR9fJfIAzNPp9DtslnT7a51xTKu9Upd4ZkcBP9MjBbql6DgDP_1TiWd8KR2BrzzHIN55CX68Op2Kp9TEP9JpRgHC0leAw-mhWFwj43NZgeuklwFP1whNhRSRCyS20K6f2hFTIROeSp1Q2fDeJ7xhdyxNAXTsw3ESV7d6AThCNfdiXKTYLFKfWO1Ts7oAyD_oX-BKtrRYvrv6IJ8fx8YaxJGvJcwuDLjgrod3k4ATU5wvt6W0wz7ZQDmI61zY1gjFmy4AOnDwfJjMvYoCS3hkqAzHoiyKeOfg_X8QHR12iB4aIp0DO6QweRkwJywN1qFc71CCIZKd4TWU2oYrRfxLZeHJRpLPHr7bDuOXYtxfpvKyonHxVI67fXKjFvyWs4A9Xc4c-N2goxId1ndHsunHqoI6DyKsanXz739rgyyDiYnf7Ozv3iKXGPZBwVAmb530FvNS3QY0ukjuVGpPyYfztjM_AdzEni0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Optimizing+exchange+transfusion+for+severe+unconjugated+hyperbilirubinemia%3A+studies+in+the+Gunn+rat&rft.jtitle=PloS+one&rft.au=Schreuder%2C+Andrea+B&rft.au=Vanikova%2C+Jana&rft.au=Vitek%2C+Libor&rft.au=Havinga%2C+Rick&rft.date=2013-10-15&rft.eissn=1932-6203&rft.volume=8&rft.issue=10&rft.spage=e77179&rft_id=info:doi/10.1371%2Fjournal.pone.0077179&rft_id=info%3Apmid%2F24143211&rft.externalDocID=24143211 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |