Alterations in White Matter Microstructure in Neurofibromatosis-1

• Published in: PloS one Vol. 7; no. 10; p. e47854
• Main Authors: Karlsgodt, Katherine H., Rosser, Tena, Lutkenhoff, Evan S., Cannon, Tyrone D., Silva, Alcino, Bearden, Carrie E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.10.2012; Public Library of Science (PLoS)
• Subjects: Adult; Alterations; Anisotropy; Attention; Attention deficit hyperactivity disorder; Axial diffusion; Axons; Axons - pathology; Biology; Brain; Brain research; Case-Control Studies; Cognitive ability; Cortex; Diffusion; Diffusion effects; Diffusion Tensor Imaging; Disabilities; Etiology; Female; Frontal lobe; Frontal Lobe - pathology; Genetic disorders; Gyrus Cinguli - pathology; Humans; Hyperactivity; Inhibition (psychology); Kinases; Learning; Magnetic resonance imaging; Male; Medical imaging; Medicine; Microstructure; Microstructures; Mutation; Myelination; Neurofibromatosis; Neurofibromatosis 1 - pathology; Neurofibromin 1 - genetics; Neuroimaging; Neurological disorders; Neurology; Neurosciences; NMR; Nuclear magnetic resonance; Organ Size; Packing; Patients; Psychiatry; Registration; Short term memory; Spatial analysis; Statistical analysis; Studies; Substantia alba; Thalamus - pathology; Tumors; Los Angeles California; United States > US; California

Neurofibromatosis (NF1) represents the most common single gene cause of learning disabilities. NF1 patients have impairments in frontal lobe based cognitive functions such as attention, working memory, and inhibition. Due to its well-characterized genetic etiology, investigations of NF1 may shed lig...