Effect of proton pump inhibitors on mortality of cirrhotic patients with pneumonia

• Published in: PloS one Vol. 14; no. 4; p. e0216041
• Main Authors: Hung, Tsung-Hsing, Tseng, Chih -Wei, Tsai, Chih-Chun, Lee, Hsing-Feng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.04.2019; Public Library of Science (PLoS)
• Subjects: Acids; Administration, Oral; Antibiotics; Bacterial infections; Bleeding; Buddhism; Care and treatment; Cirrhosis; Clinical medicine; Comorbidity; Complications and side effects; Confidence intervals; Datasets; Development and progression; Disease; Disorders; Drug dosages; Esophagus; Female; Gastrointestinal hemorrhage; Gastrointestinal Hemorrhage - chemically induced; Health insurance; Hospital patients; Hospitalization; Hospitals; Humans; Infections; Inhibitors; Insurance; Liver; Liver cirrhosis; Liver Cirrhosis - complications; Liver Cirrhosis - drug therapy; Liver Cirrhosis - mortality; Male; Medical records; Medicine; Middle Aged; Mortality; National health insurance; Pantoprazole; Patient outcomes; Pneumonia; Pneumonia - complications; Proportional Hazards Models; Proton pump inhibitors; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - therapeutic use; Regression models; Risk Factors; Statistical analysis; Survival Analysis; Systematic review; Ulcers; Taiwan

Pneumonia is life-threatening in patients with liver cirrhosis. Proton pump inhibitors (PPIs) may increase the risk of these patients developing pneumonia. However, whether PPIs increase mortality in patients with cirrhosis and pneumonia remain unknown. We used the Taiwan National Health Insurance D...