Pre-Existing Immunity with High Neutralizing Activity to 2009 Pandemic H1N1 Influenza Virus in Shanghai Population

• Published in: PloS one Vol. 8; no. 3; p. e58810
• Main Authors: Liu, Xiaoqing, Liu, Yuan, Zhang, Yanjun, Chen, Zhihui, Tang, Ziwei, Xu, Qingqiang, Wang, Yue, Zhao, Ping, Qi, Zhongtian
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.03.2013; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Antibodies; Antibodies, Neutralizing; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody Specificity; Antigenic determinants; Binding sites; Biology; Cell Line; China; Correlation; Cross Reactions - immunology; Deoxyribonucleic acid; Disease control; Disease prevention; DNA; Epidemiology; Epitopes; Epitopes, B-Lymphocyte - chemistry; Epitopes, B-Lymphocyte - immunology; Evolution & development; Female; Health aspects; Hemagglutination inhibition; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Humans; Immunity; Immunization; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulins; Infections; Influenza; Influenza A Virus, H1N1 Subtype - immunology; Influenza viruses; Influenza, Human - epidemiology; Influenza, Human - immunology; Influenza, Human - prevention & control; Laboratories; Lymphocytes B; Male; Medicine; Mice; Middle Aged; Neutralization Tests; Neutralizing; Orthomyxoviridae; Pandemics; Pathogenesis; Plasmids; Population; Swine flu; Swine influenza; Vaccines; Viruses; Young Adult; China; United States > US; Shanghai China

Pre-existing immunity is an important factor countering the pandemic potential of an emerging influenza virus strain. Thus, studying of pre-existing immunity to the 2009 pandemic H1N1 virus (2009 H1N1) will advance our understanding of the pathogenesis and epidemiology of this emerging pathogen. In...