Identification of host genes involved in geminivirus infection using a reverse genetics approach

Geminiviruses, like all viruses, rely on the host cell machinery to establish a successful infection, but the identity and function of these required host proteins remain largely unknown. Tomato yellow leaf curl Sardinia virus (TYLCSV), a monopartite geminivirus, is one of the causal agents of the d...

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Published inPloS one Vol. 6; no. 7; p. e22383
Main Authors Lozano-Durán, Rosa, Rosas-Díaz, Tábata, Luna, Ana P, Bejarano, Eduardo R
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 26.07.2011
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Abstract Geminiviruses, like all viruses, rely on the host cell machinery to establish a successful infection, but the identity and function of these required host proteins remain largely unknown. Tomato yellow leaf curl Sardinia virus (TYLCSV), a monopartite geminivirus, is one of the causal agents of the devastating Tomato yellow leaf curl disease (TYLCD). The transgenic 2IRGFP N. benthamiana plants, used in combination with Virus Induced Gene Silencing (VIGS), entail an important potential as a tool in reverse genetics studies to identify host factors involved in TYLCSV infection. Using these transgenic plants, we have made an accurate description of the evolution of TYLCSV replication in the host in both space and time. Moreover, we have determined that TYLCSV and Tobacco rattle virus (TRV) do not dramatically influence each other when co-infected in N. benthamiana, what makes the use of TRV-induced gene silencing in combination with TYLCSV for reverse genetic studies feasible. Finally, we have tested the effect of silencing candidate host genes on TYLCSV infection, identifying eighteen genes potentially involved in this process, fifteen of which had never been implicated in geminiviral infections before. Seven of the analyzed genes have a potential anti-viral effect, whereas the expression of the other eleven is required for a full infection. Interestingly, almost half of the genes altering TYLCSV infection play a role in postranslational modifications. Therefore, our results provide new insights into the molecular mechanisms underlying geminivirus infections, and at the same time reveal the 2IRGFP/VIGS system as a powerful tool for functional reverse genetics studies.
AbstractList Geminiviruses, like all viruses, rely on the host cell machinery to establish a successful infection, but the identity and function of these required host proteins remain largely unknown. Tomato yellow leaf curl Sardinia virus (TYLCSV), a monopartite geminivirus, is one of the causal agents of the devastating Tomato yellow leaf curl disease (TYLCD). The transgenic 2IRGFP N. benthamiana plants, used in combination with Virus Induced Gene Silencing (VIGS), entail an important potential as a tool in reverse genetics studies to identify host factors involved in TYLCSV infection. Using these transgenic plants, we have made an accurate description of the evolution of TYLCSV replication in the host in both space and time. Moreover, we have determined that TYLCSV and Tobacco rattle virus (TRV) do not dramatically influence each other when co-infected in N. benthamiana, what makes the use of TRV-induced gene silencing in combination with TYLCSV for reverse genetic studies feasible. Finally, we have tested the effect of silencing candidate host genes on TYLCSV infection, identifying eighteen genes potentially involved in this process, fifteen of which had never been implicated in geminiviral infections before. Seven of the analyzed genes have a potential anti-viral effect, whereas the expression of the other eleven is required for a full infection. Interestingly, almost half of the genes altering TYLCSV infection play a role in postranslational modifications. Therefore, our results provide new insights into the molecular mechanisms underlying geminivirus infections, and at the same time reveal the 2IRGFP/VIGS system as a powerful tool for functional reverse genetics studies.
Geminiviruses, like all viruses, rely on the host cell machinery to establish a successful infection, but the identity and function of these required host proteins remain largely unknown. Tomato yellow leaf curl Sardinia virus (TYLCSV), a monopartite geminivirus, is one of the causal agents of the devastating Tomato yellow leaf curl disease (TYLCD). The transgenic 2IRGFP N. benthamiana plants, used in combination with Virus Induced Gene Silencing (VIGS), entail an important potential as a tool in reverse genetics studies to identify host factors involved in TYLCSV infection. Using these transgenic plants, we have made an accurate description of the evolution of TYLCSV replication in the host in both space and time. Moreover, we have determined that TYLCSV and Tobacco rattle virus (TRV) do not dramatically influence each other when co-infected in N. benthamiana , what makes the use of TRV-induced gene silencing in combination with TYLCSV for reverse genetic studies feasible. Finally, we have tested the effect of silencing candidate host genes on TYLCSV infection, identifying eighteen genes potentially involved in this process, fifteen of which had never been implicated in geminiviral infections before. Seven of the analyzed genes have a potential anti-viral effect, whereas the expression of the other eleven is required for a full infection. Interestingly, almost half of the genes altering TYLCSV infection play a role in postranslational modifications. Therefore, our results provide new insights into the molecular mechanisms underlying geminivirus infections, and at the same time reveal the 2IRGFP/VIGS system as a powerful tool for functional reverse genetics studies.
Audience Academic
Author Luna, Ana P
Lozano-Durán, Rosa
Rosas-Díaz, Tábata
Bejarano, Eduardo R
AuthorAffiliation Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento Biología Celular, Genética y Fisiología, Universidad de Málaga, Campus Teatinos, Málaga, Spain
Instituto de Biología Molecular y Celular de Plantas, Spain
AuthorAffiliation_xml – name: Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento Biología Celular, Genética y Fisiología, Universidad de Málaga, Campus Teatinos, Málaga, Spain
– name: Instituto de Biología Molecular y Celular de Plantas, Spain
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  givenname: Rosa
  surname: Lozano-Durán
  fullname: Lozano-Durán, Rosa
  organization: Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento Biología Celular, Genética y Fisiología, Universidad de Málaga, Campus Teatinos, Málaga, Spain
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  givenname: Tábata
  surname: Rosas-Díaz
  fullname: Rosas-Díaz, Tábata
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  givenname: Ana P
  surname: Luna
  fullname: Luna, Ana P
– sequence: 4
  givenname: Eduardo R
  surname: Bejarano
  fullname: Bejarano, Eduardo R
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21818318$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1104/pp.126.2.789
10.1146/annurev.biochem.76.052705.161529
10.1093/emboj/19.13.3485
10.1105/tpc.107.051896
10.1186/1743-422X-7-373
10.1016/j.virol.2010.02.011
10.1186/1746-4811-4-5
10.1074/jbc.M405259200
10.1104/pp.104.058958
10.1128/MCB.17.9.5077
10.1006/viro.1999.0119
10.1094/MPMI-23-3-0283
10.1007/978-1-4020-4769-5
10.1016/j.ejcb.2009.11.021
10.1515/DMDI.2008.23.1-2.51
10.1034/j.1399-3054.2002.1140201.x
10.1146/annurev.phyto.43.040204.135939
10.1111/j.1399-3054.2007.00961.x
10.1105/tpc.012120
10.1099/vir.0.80920-0
10.1111/j.1365-313X.2005.02578.x
10.1534/genetics.108.091108
10.1007/BF00027399
10.1038/39215
10.1111/j.1469-8137.2007.02225.x
10.1023/A:1006496308160
10.1104/pp.105.075556
10.1111/j.1364-3703.2009.00596.x
10.1074/jbc.M109.095075
10.1105/tpc.10.6.937
10.1094/MPMI-22-11-1431
10.1104/pp.109.139006
10.1007/s11103-004-0590-7
10.1128/JVI.79.4.2517-2527.2005
10.1046/j.1365-313X.2002.01423.x
10.1111/j.1399-3054.2008.01189.x
10.1111/j.1365-313X.2005.02592.x
10.1073/pnas.0407758101
10.1104/pp.107.101105
10.1046/j.0960-7412.2000.00942.x
10.1016/j.semcdb.2009.05.012
10.1046/j.1365-313X.2003.01855.x
10.1093/jxb/erl138
10.1104/pp.108.121038
10.1093/jxb/ern082
10.1016/j.plaphy.2010.10.004
10.1111/j.1364-3703.2010.00618.x
10.1128/JVI.78.6.2758-2769.2004
10.1046/j.1365-313X.2003.01944.x
10.1007/s11103-009-9506-x
10.1042/BST0380060
10.1146/annurev.cellbio.20.010403.105307
10.1105/tpc.109.072272
10.1128/JVI.80.7.3624-3633.2006
10.4161/psb.6.7.15499
10.1105/tpc.017772
10.1006/meth.2001.1262
10.1308/rcsann.2006.88.4.412b
10.1094/PD-72-0949
10.1046/j.1365-313x.2001.00976.x
10.1104/pp.107.100404
10.1146/annurev.arplant.54.031902.134847
10.1016/S0168-1702(00)00193-3
10.1023/A:1006138221874
10.1094/MPMI-22-6-0737
10.1046/j.1365-313x.2001.01080.x
10.1007/978-1-60761-702-0_6
10.1126/science.1142204
10.1023/A:1005991617182
10.1104/pp.107.105916
10.1073/pnas.0909080107
10.1093/aob/mcl255
10.1094/MPMI-22-4-0469
10.1016/j.virol.2006.12.034
10.1105/tpc.003681
10.1093/nar/gkl1088
10.1111/j.1364-3703.2010.00630.x
10.1111/j.1365-313X.2008.03737.x
10.1093/pcp/pcq056
10.1007/s00425-009-1072-6
10.1111/j.1365-313X.2004.02158.x
10.1046/j.1365-313X.1998.00101.x
10.1105/tpc.015180
10.1111/j.1365-313X.2010.04295.x
10.1105/tpc.104.027235
ContentType Journal Article
Copyright COPYRIGHT 2011 Public Library of Science
2011 Lozano-Durán et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Lozano-Durán et al. 2011
Copyright_xml – notice: COPYRIGHT 2011 Public Library of Science
– notice: 2011 Lozano-Durán et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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content type line 23
Current address: The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom
Conceived and designed the experiments: RL-D TR-D ERB. Performed the experiments: RL-D TR-D APL. Analyzed the data: RL-D TR-D ERB. Contributed reagents/materials/analysis tools: ERB. Wrote the paper: RL-D TR-D ERB.
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144222/
PMID 21818318
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References Y Guo (ref42) 2010; 63
B Spitzer (ref19) 2007; 145
MR Rojas (ref1) 2005; 43
JD Lewis (ref68) 2010; 107
O Guerra-Peraza (ref71) 2005; 86
T Umezawa (ref38) 2004; 101
S La Camera (ref56) 2009; 22
A Mustafiz (ref58) 2010; 639
J Lai (ref36) 2008; 57
M Escaler (ref48) 2000; 267
F Aparicio (ref49) 2005; 138
Q Xie (ref29) 1999; 39
O Eini (ref35) 2009; 22
BJ DeYoung (ref43) 2006; 45
F Ausubel (ref74) 1998
D Trinks (ref9) 2005; 79
JT Ascencio-Ibanez (ref6) 2008; 148
SF Clarke (ref60) 2002; 114
A Garcia-Marcos (ref61) 2009; 22
F Vilaine (ref82) 2003; 36
T Asano (ref89) 2002; 32
SJ Davis (ref76) 1998; 36
S Kjemtrup (ref17) 1998; 14
J Rimmer (ref65) 2006; 88
F Liu (ref40) 2004; 16
K Dreher (ref33) 2007; 99
LJ Kong (ref85) 2000; 19
R Lozano-Duran (ref10) 2011
J Sambrook (ref75) 2001
H Wang (ref87) 2003; 15
S Andleeb (ref8) 2010; 7
RA Ach (ref84) 1997; 17
JS Elmer (ref77) 1988; 10
LJ Kong (ref81) 2002; 14
AS Dielen (ref52) 2010; 11
RC McGarry (ref30) 2003; 15
P Diaz-Vivancos (ref63) 2008; 59
MC Lee (ref67) 2004; 20
J Yang (ref73) 2010; 49
E Liu (ref25) 2008; 4
BJ Deyoung (ref44) 2008; 180
P Diaz-Vivancos (ref64) 2006; 57
N Piroux (ref45) 2007; 362
C Peele (ref21) 2001; 27
MT Ruiz (ref16) 1998; 10
SK Ekengren (ref23) 2003; 36
J Stanley (ref2) 2005
F Ratcliff (ref27) 2001; 25
T Bennett (ref72) 2010; 22
LA Selth (ref83) 2005; 17
H Czosnek (ref4) 2007
PP Sahu (ref7) 2010; 11
DY Sung (ref47) 2001; 126
W Sun (ref59) 2010; 51
DK Singh (ref32) 2006; 35
M Senthil-Kumar (ref26) 2007; 176
B Krenz (ref53) 2010; 401
RW Shultz (ref80) 2007; 144
G Morilla (ref11) 2006; 80
JA Diaz-Pendon (ref5) 2010; 11
J Chen (ref20) 2004; 55
D Orzaez (ref18) 2009; 150
K Amari (ref62) 2007; 131
LJ Terry (ref70) 2007; 318
LM Lois (ref88) 2010; 38
CL Thomas (ref22) 2001; 25
XS Song (ref66) 2009; 135
RP Hellens (ref78) 2000; 42
AG Castillo (ref12) 2004; 78
N Lampl (ref54) 2010; 285
R Ber (ref13) 1990
AW Woodward (ref86) 2007; 144
A Eybishtz (ref28) 2010; 231
SC Dogra (ref46) 2009; 71
S La Camera (ref55) 2005; 44
TM Burch-Smith (ref24) 2004; 39
R Lozano-Durán (ref37) 2011
M Boudsocq (ref39) 2004; 279
E Moriones (ref3) 2000; 71
A Cook (ref69) 2007; 76
C Schwechheimer (ref90) 2010; 89
MF Carvalho (ref31) 2006; 140
SK Yadav (ref57) 2008; 23
K Komatsu (ref51) 2010; 23
G Serino (ref41) 2003; 54
O Voinnet (ref15) 1997; 389
H Czosnek (ref14) 1988; 72
KJ Livak (ref79) 2001; 25
V Citovsky (ref34) 2009; 20
LD Noel (ref50) 2007; 19
References_xml – volume: 126
  start-page: 789
  year: 2001
  ident: ref47
  article-title: Comprehensive expression profile analysis of the Arabidopsis Hsp70 gene family.
  publication-title: Plant Physiol
  doi: 10.1104/pp.126.2.789
  contributor:
    fullname: DY Sung
– volume: 76
  start-page: 647
  year: 2007
  ident: ref69
  article-title: Structural biology of nucleocytoplasmic transport.
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.biochem.76.052705.161529
  contributor:
    fullname: A Cook
– volume: 19
  start-page: 3485
  year: 2000
  ident: ref85
  article-title: A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants.
  publication-title: EMBO J
  doi: 10.1093/emboj/19.13.3485
  contributor:
    fullname: LJ Kong
– volume: 19
  start-page: 4061
  year: 2007
  ident: ref50
  article-title: Interaction between SGT1 and cytosolic/nuclear HSC70 chaperones regulates Arabidopsis immune responses.
  publication-title: Plant Cell
  doi: 10.1105/tpc.107.051896
  contributor:
    fullname: LD Noel
– volume: 7
  start-page: 373
  year: 2010
  ident: ref8
  article-title: Transient expression of betaC1 protein differentially regulates host genes related to stress response, chloroplast and mitochondrial functions.
  publication-title: Virol J
  doi: 10.1186/1743-422X-7-373
  contributor:
    fullname: S Andleeb
– year: 1998
  ident: ref74
  article-title: Current protocols in molecular biology
  contributor:
    fullname: F Ausubel
– volume: 401
  start-page: 6
  year: 2010
  ident: ref53
  article-title: A plastid-targeted heat shock cognate 70kDa protein interacts with the Abutilon mosaic virus movement protein.
  publication-title: Virology
  doi: 10.1016/j.virol.2010.02.011
  contributor:
    fullname: B Krenz
– volume: 4
  start-page: 5
  year: 2008
  ident: ref25
  article-title: Optimized cDNA libraries for virus-induced gene silencing (VIGS) using tobacco rattle virus.
  publication-title: Plant Methods
  doi: 10.1186/1746-4811-4-5
  contributor:
    fullname: E Liu
– volume: 279
  start-page: 41758
  year: 2004
  ident: ref39
  article-title: Identification of nine sucrose nonfermenting 1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana.
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M405259200
  contributor:
    fullname: M Boudsocq
– volume: 138
  start-page: 529
  year: 2005
  ident: ref49
  article-title: Virus Induction of Heat Shock Protein 70 Reflects a General Response to Protein Accumulation in the Plant Cytosol.
  publication-title: Plant Physiol
  doi: 10.1104/pp.104.058958
  contributor:
    fullname: F Aparicio
– volume: 17
  start-page: 5077
  year: 1997
  ident: ref84
  article-title: RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein.
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.17.9.5077
  contributor:
    fullname: RA Ach
– volume: 267
  start-page: 318
  year: 2000
  ident: ref48
  article-title: Pea embryonic tissues show common responses to the replication of a wide range of viruses.
  publication-title: Virology
  doi: 10.1006/viro.1999.0119
  contributor:
    fullname: M Escaler
– year: 1990
  ident: ref13
  article-title: Infection of tomato by tomato yellow leaf curl virus: suceptibility to infection, symptom development and accumulation of viral DNA.
  publication-title: Arch Virology
  contributor:
    fullname: R Ber
– year: 2001
  ident: ref75
  article-title: Molecular cloning: a laboratory manual.
  contributor:
    fullname: J Sambrook
– volume: 23
  start-page: 283
  year: 2010
  ident: ref51
  article-title: Viral-induced systemic necrosis in plants involves both programmed cell death and the inhibition of viral multiplication, which are regulated by independent pathways.
  publication-title: Mol Plant Microbe Interact
  doi: 10.1094/MPMI-23-3-0283
  contributor:
    fullname: K Komatsu
– year: 2007
  ident: ref4
  article-title: Tomato Yellow Leaf Curl Disease.
  doi: 10.1007/978-1-4020-4769-5
  contributor:
    fullname: H Czosnek
– volume: 89
  start-page: 157
  year: 2010
  ident: ref90
  article-title: The COP9 signalosome and its role in plant development.
  publication-title: Eur J Cell Biol
  doi: 10.1016/j.ejcb.2009.11.021
  contributor:
    fullname: C Schwechheimer
– volume: 23
  start-page: 51
  year: 2008
  ident: ref57
  article-title: An overview on the role of methylglyoxal and glyoxalases in plants.
  publication-title: Drug Metabol Drug Interact
  doi: 10.1515/DMDI.2008.23.1-2.51
  contributor:
    fullname: SK Yadav
– volume: 114
  start-page: 157
  year: 2002
  ident: ref60
  article-title: Changes in the activities of antioxidant enzymes in response to virus infection and hormone treatment.
  publication-title: Physiol Plant
  doi: 10.1034/j.1399-3054.2002.1140201.x
  contributor:
    fullname: SF Clarke
– volume: 43
  start-page: 361
  year: 2005
  ident: ref1
  article-title: Exploiting chinks in the plant's armor: evolution and emergence of geminiviruses.
  publication-title: Annu Rev Phytopathol
  doi: 10.1146/annurev.phyto.43.040204.135939
  contributor:
    fullname: MR Rojas
– volume: 131
  start-page: 302
  year: 2007
  ident: ref62
  article-title: Oxidative stress induction by Prunus necrotic ringspot virus infection in apricot seeds.
  publication-title: Physiol Plant
  doi: 10.1111/j.1399-3054.2007.00961.x
  contributor:
    fullname: K Amari
– volume: 15
  start-page: 1605
  year: 2003
  ident: ref30
  article-title: A novel Arabidopsis acetyltransferase interacts with the geminivirus movement protein NSP.
  publication-title: Plant Cell
  doi: 10.1105/tpc.012120
  contributor:
    fullname: RC McGarry
– volume: 86
  start-page: 1815
  year: 2005
  ident: ref71
  article-title: Coat proteins of Rice tungro bacilliform virus and Mungbean yellow mosaic virus contain multiple nuclear-localization signals and interact with importin alpha.
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.80920-0
  contributor:
    fullname: O Guerra-Peraza
– volume: 44
  start-page: 810
  year: 2005
  ident: ref55
  article-title: A pathogen-inducible patatin-like lipid acyl hydrolase facilitates fungal and bacterial host colonization in Arabidopsis.
  publication-title: Plant J
  doi: 10.1111/j.1365-313X.2005.02578.x
  contributor:
    fullname: S La Camera
– volume: 180
  start-page: 895
  year: 2008
  ident: ref44
  article-title: BAM receptors regulate stem cell specification and organ development through complex interactions with CLAVATA signaling.
  publication-title: Genetics
  doi: 10.1534/genetics.108.091108
  contributor:
    fullname: BJ Deyoung
– volume: 10
  start-page: 225
  year: 1988
  ident: ref77
  article-title: Agrobacterium-mediated inoculation of plants with tomato golden mosaic virus DNAs.
  publication-title: Plant Mol Biol
  doi: 10.1007/BF00027399
  contributor:
    fullname: JS Elmer
– volume: 389
  start-page: 553
  year: 1997
  ident: ref15
  article-title: Systemic signalling in gene silencing.
  publication-title: Nature
  doi: 10.1038/39215
  contributor:
    fullname: O Voinnet
– volume: 176
  start-page: 782
  year: 2007
  ident: ref26
  article-title: A systematic study to determine the extent of gene silencing in Nicotiana benthamiana and other Solanaceae species when heterologous gene sequences are used for virus-induced gene silencing.
  publication-title: New Phytol
  doi: 10.1111/j.1469-8137.2007.02225.x
  contributor:
    fullname: M Senthil-Kumar
– volume: 42
  start-page: 819
  year: 2000
  ident: ref78
  article-title: pGreen: a versatile and flexible binary Ti vector for Agrobacterium-mediated plant transformation.
  publication-title: Plant Mol Biol
  doi: 10.1023/A:1006496308160
  contributor:
    fullname: RP Hellens
– volume: 140
  start-page: 1317
  year: 2006
  ident: ref31
  article-title: The geminivirus nuclear shuttle protein NSP inhibits the activity of AtNSI, a vascular-expressed Arabidopsis acetyltransferase regulated with the sink-to-source transition.
  publication-title: Plant Physiol
  doi: 10.1104/pp.105.075556
  contributor:
    fullname: MF Carvalho
– volume: 11
  start-page: 293
  year: 2010
  ident: ref52
  article-title: The ubiquitin/26S proteasome system in plant-pathogen interactions: a never-ending hide-and-seek game.
  publication-title: Mol Plant Pathol
  doi: 10.1111/j.1364-3703.2009.00596.x
  contributor:
    fullname: AS Dielen
– volume: 285
  start-page: 13550
  year: 2010
  ident: ref54
  article-title: Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21).
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.095075
  contributor:
    fullname: N Lampl
– volume: 10
  start-page: 937
  year: 1998
  ident: ref16
  article-title: Initiation and maintenance of virus-induced gene silencing.
  publication-title: Plant Cell
  doi: 10.1105/tpc.10.6.937
  contributor:
    fullname: MT Ruiz
– volume: 22
  start-page: 1431
  year: 2009
  ident: ref61
  article-title: Transcriptional changes and oxidative stress associated with the synergistic interaction between Potato virus X and Potato virus Y and their relationship with symptom expression.
  publication-title: Mol Plant Microbe Interact
  doi: 10.1094/MPMI-22-11-1431
  contributor:
    fullname: A Garcia-Marcos
– volume: 150
  start-page: 1122
  year: 2009
  ident: ref18
  article-title: A visual reporter system for virus-induced gene silencing in tomato fruit based on anthocyanin accumulation.
  publication-title: Plant Physiol
  doi: 10.1104/pp.109.139006
  contributor:
    fullname: D Orzaez
– volume: 55
  start-page: 521
  year: 2004
  ident: ref20
  article-title: Chalcone synthase as a reporter in virus-induced gene silencing studies of flower senescence.
  publication-title: Plant Molecular Biology
  doi: 10.1007/s11103-004-0590-7
  contributor:
    fullname: J Chen
– volume: 79
  start-page: 2517
  year: 2005
  ident: ref9
  article-title: Suppression of RNA silencing by a geminivirus nuclear protein, AC2, correlates with transactivation of host genes.
  publication-title: J Virol
  doi: 10.1128/JVI.79.4.2517-2527.2005
  contributor:
    fullname: D Trinks
– volume: 32
  start-page: 401
  year: 2002
  ident: ref89
  article-title: Construction of a specialized cDNA library from plant cells isolated by laser capture microdissection: toward comprehensive analysis of the genes expressed in the rice phloem.
  publication-title: Plant J
  doi: 10.1046/j.1365-313X.2002.01423.x
  contributor:
    fullname: T Asano
– volume: 135
  start-page: 246
  year: 2009
  ident: ref66
  article-title: Effects of cucumber mosaic virus infection on electron transport and antioxidant system in chloroplasts and mitochondria of cucumber and tomato leaves.
  publication-title: Physiol Plant
  doi: 10.1111/j.1399-3054.2008.01189.x
  contributor:
    fullname: XS Song
– volume: 45
  start-page: 1
  year: 2006
  ident: ref43
  article-title: The CLAVATA1-related BAM1, BAM2 and BAM3 receptor kinase-like proteins are required for meristem function in Arabidopsis.
  publication-title: Plant J
  doi: 10.1111/j.1365-313X.2005.02592.x
  contributor:
    fullname: BJ DeYoung
– volume: 101
  start-page: 17306
  year: 2004
  ident: ref38
  article-title: SRK2C, a SNF1-related protein kinase 2, improves drought tolerance by controlling stress-responsive gene expression in Arabidopsis thaliana.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0407758101
  contributor:
    fullname: T Umezawa
– volume: 144
  start-page: 1697
  year: 2007
  ident: ref80
  article-title: Genome-wide analysis of the core DNA replication machinery in the higher plants Arabidopsis and rice.
  publication-title: Plant Physiol
  doi: 10.1104/pp.107.101105
  contributor:
    fullname: RW Shultz
– year: 2011
  ident: ref10
  article-title: Geminiviruses Subvert Ubiquitination by Altering CSN-Mediated Derubylation of SCF E3 Ligase Complexes and Inhibit Jasmonate Signaling in Arabidopsis thaliana.
  publication-title: Plant Cell
  contributor:
    fullname: R Lozano-Duran
– volume: 25
  start-page: 237
  year: 2001
  ident: ref27
  article-title: Tobacco rattle virus as a vector for analysis of gene function by silencing.
  publication-title: The Plant Journal
  doi: 10.1046/j.0960-7412.2000.00942.x
  contributor:
    fullname: F Ratcliff
– volume: 20
  start-page: 1048
  year: 2009
  ident: ref34
  article-title: Proteasomal degradation in plant-pathogen interactions.
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2009.05.012
  contributor:
    fullname: V Citovsky
– volume: 36
  start-page: 67
  year: 2003
  ident: ref82
  article-title: Towards deciphering phloem: a transcriptome analysis of the phloem of Apium graveolens.
  publication-title: Plant J
  doi: 10.1046/j.1365-313X.2003.01855.x
  contributor:
    fullname: F Vilaine
– volume: 57
  start-page: 3813
  year: 2006
  ident: ref64
  article-title: The apoplastic antioxidant system in Prunus: response to long-term plum pox virus infection.
  publication-title: J Exp Bot
  doi: 10.1093/jxb/erl138
  contributor:
    fullname: P Diaz-Vivancos
– volume: 148
  start-page: 436
  year: 2008
  ident: ref6
  article-title: Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
  publication-title: Plant Physiol
  doi: 10.1104/pp.108.121038
  contributor:
    fullname: JT Ascencio-Ibanez
– volume: 59
  start-page: 2147
  year: 2008
  ident: ref63
  article-title: Alteration in the chloroplastic metabolism leads to ROS accumulation in pea plants in response to plum pox virus.
  publication-title: J Exp Bot
  doi: 10.1093/jxb/ern082
  contributor:
    fullname: P Diaz-Vivancos
– volume: 49
  start-page: 103
  year: 2010
  ident: ref73
  article-title: Controlled silencing of 4-coumarate:CoA ligase alters lignocellulose composition without affecting stem growth.
  publication-title: Plant Physiol Biochem
  doi: 10.1016/j.plaphy.2010.10.004
  contributor:
    fullname: J Yang
– volume: 11
  start-page: 441
  year: 2010
  ident: ref5
  article-title: Tomato yellow leaf curl viruses: menage a trois between the virus complex, the plant and the whitefly vector.
  publication-title: Mol Plant Pathol
  doi: 10.1111/j.1364-3703.2010.00618.x
  contributor:
    fullname: JA Diaz-Pendon
– volume: 78
  start-page: 2758
  year: 2004
  ident: ref12
  article-title: Interaction between a geminivirus replication protein and the plant sumoylation system.
  publication-title: J Virol
  doi: 10.1128/JVI.78.6.2758-2769.2004
  contributor:
    fullname: AG Castillo
– volume: 36
  start-page: 905
  year: 2003
  ident: ref23
  article-title: Two MAPK cascades, NPR1, and TGA transcription factors play a role in Pto-mediated disease resistance in tomato.
  publication-title: Plant J
  doi: 10.1046/j.1365-313X.2003.01944.x
  contributor:
    fullname: SK Ekengren
– volume: 71
  start-page: 25
  year: 2009
  ident: ref46
  article-title: A novel shaggy-like kinase interacts with the Tomato leaf curl virus pathogenicity determinant C4 protein.
  publication-title: Plant Mol Biol
  doi: 10.1007/s11103-009-9506-x
  contributor:
    fullname: SC Dogra
– volume: 38
  start-page: 60
  year: 2010
  ident: ref88
  article-title: Diversity of the SUMOylation machinery in plants.
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0380060
  contributor:
    fullname: LM Lois
– volume: 20
  start-page: 87
  year: 2004
  ident: ref67
  article-title: Bi-directional protein transport between the ER and Golgi.
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev.cellbio.20.010403.105307
  contributor:
    fullname: MC Lee
– volume: 22
  start-page: 640
  year: 2010
  ident: ref72
  article-title: SOMBRERO, BEARSKIN1, and BEARSKIN2 regulate root cap maturation in Arabidopsis.
  publication-title: Plant Cell
  doi: 10.1105/tpc.109.072272
  contributor:
    fullname: T Bennett
– volume: 80
  start-page: 3624
  year: 2006
  ident: ref11
  article-title: A versatile transreplication-based system to identify cellular proteins involved in geminivirus replication.
  publication-title: J Virol
  doi: 10.1128/JVI.80.7.3624-3633.2006
  contributor:
    fullname: G Morilla
– year: 2011
  ident: ref37
  article-title: Geminivirus C2 protein might be the key player for geminiviral co-option of SCF-mediated ubiquitination.
  doi: 10.4161/psb.6.7.15499
  contributor:
    fullname: R Lozano-Durán
– volume: 16
  start-page: 5
  year: 2004
  ident: ref40
  article-title: The ASK1 and ASK2 genes are essential for Arabidopsis early development.
  publication-title: Plant Cell
  doi: 10.1105/tpc.017772
  contributor:
    fullname: F Liu
– volume: 25
  start-page: 402
  year: 2001
  ident: ref79
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
  contributor:
    fullname: KJ Livak
– volume: 88
  start-page: 412
  year: 2006
  ident: ref65
  article-title: The use of octyl-2-cyanoacrylate (Dermabond) tissue adhesive for skin closure in head and neck surgery.
  publication-title: Ann R Coll Surg Engl
  doi: 10.1308/rcsann.2006.88.4.412b
  contributor:
    fullname: J Rimmer
– volume: 72
  start-page: 949
  year: 1988
  ident: ref14
  article-title: Detection of tomato yellow leaf curl virus in lysates of plants and insects by hybridization with a viral DNA probe.
  publication-title: Plant disease
  doi: 10.1094/PD-72-0949
  contributor:
    fullname: H Czosnek
– volume: 25
  start-page: 417
  year: 2001
  ident: ref22
  article-title: Size constraints for targeting post-transcriptional gene silencing and for RNA-directed methylation in Nicotiana benthamiana using a potato virus X vector.
  publication-title: Plant J
  doi: 10.1046/j.1365-313x.2001.00976.x
  contributor:
    fullname: CL Thomas
– volume: 144
  start-page: 976
  year: 2007
  ident: ref86
  article-title: Mutation of E1-CONJUGATING ENZYME-RELATED1 decreases RELATED TO UBIQUITIN conjugation and alters auxin response and development.
  publication-title: Plant Physiol
  doi: 10.1104/pp.107.100404
  contributor:
    fullname: AW Woodward
– volume: 54
  start-page: 165
  year: 2003
  ident: ref41
  article-title: The COP9 signalosome: regulating plant development through the control of proteolysis.
  publication-title: Annu Rev Plant Biol
  doi: 10.1146/annurev.arplant.54.031902.134847
  contributor:
    fullname: G Serino
– volume: 71
  start-page: 123
  year: 2000
  ident: ref3
  article-title: Tomato yellow leaf curl virus, an emerging virus complex causing epidemics worldwide.
  publication-title: Virus Res
  doi: 10.1016/S0168-1702(00)00193-3
  contributor:
    fullname: E Moriones
– volume: 39
  start-page: 647
  year: 1999
  ident: ref29
  article-title: GRAB proteins, novel members of the NAC domain family, isolated by their interaction with a geminivirus protein.
  publication-title: Plant Mol Biol
  doi: 10.1023/A:1006138221874
  contributor:
    fullname: Q Xie
– volume: 22
  start-page: 737
  year: 2009
  ident: ref35
  article-title: Interaction with a host ubiquitin-conjugating enzyme is required for the pathogenicity of a geminiviral DNA beta satellite.
  publication-title: Mol Plant Microbe Interact
  doi: 10.1094/MPMI-22-6-0737
  contributor:
    fullname: O Eini
– start-page: 301
  year: 2005
  ident: ref2
  article-title: Geminiviridae.
  contributor:
    fullname: J Stanley
– volume: 27
  start-page: 357
  year: 2001
  ident: ref21
  article-title: Silencing of a meristematic gene using geminivirus-derived vectors.
  publication-title: Plant J
  doi: 10.1046/j.1365-313x.2001.01080.x
  contributor:
    fullname: C Peele
– volume: 639
  start-page: 95
  year: 2010
  ident: ref58
  article-title: Metabolic engineering of glyoxalase pathway for enhancing stress tolerance in plants.
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-60761-702-0_6
  contributor:
    fullname: A Mustafiz
– volume: 318
  start-page: 1412
  year: 2007
  ident: ref70
  article-title: Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport.
  publication-title: Science
  doi: 10.1126/science.1142204
  contributor:
    fullname: LJ Terry
– volume: 36
  start-page: 521
  year: 1998
  ident: ref76
  article-title: Soluble, highly fluorescent variants of green fluorescent protein (GFP) for use in higher plants.
  publication-title: Plant Mol Biol
  doi: 10.1023/A:1005991617182
  contributor:
    fullname: SJ Davis
– volume: 145
  start-page: 1241
  year: 2007
  ident: ref19
  article-title: Reverse genetics of floral scent: application of tobacco rattle virus-based gene silencing in Petunia.
  publication-title: Plant Physiol
  doi: 10.1104/pp.107.105916
  contributor:
    fullname: B Spitzer
– volume: 107
  start-page: 2491
  year: 2010
  ident: ref68
  article-title: Arabidopsis synaptotagmin SYTA regulates endocytosis and virus movement protein cell-to-cell transport.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0909080107
  contributor:
    fullname: JD Lewis
– volume: 99
  start-page: 787
  year: 2007
  ident: ref33
  article-title: Ubiquitin, hormones and biotic stress in plants.
  publication-title: Ann Bot
  doi: 10.1093/aob/mcl255
  contributor:
    fullname: K Dreher
– volume: 22
  start-page: 469
  year: 2009
  ident: ref56
  article-title: The Arabidopsis patatin-like protein 2 (PLP2) plays an essential role in cell death execution and differentially affects biosynthesis of oxylipins and resistance to pathogens.
  publication-title: Mol Plant Microbe Interact
  doi: 10.1094/MPMI-22-4-0469
  contributor:
    fullname: S La Camera
– volume: 362
  start-page: 428
  year: 2007
  ident: ref45
  article-title: Geminivirus pathogenicity protein C4 interacts with Arabidopsis thaliana shaggy-related protein kinase AtSKeta, a component of the brassinosteroid signalling pathway.
  publication-title: Virology
  doi: 10.1016/j.virol.2006.12.034
  contributor:
    fullname: N Piroux
– volume: 14
  start-page: 1817
  year: 2002
  ident: ref81
  article-title: A geminivirus replication protein interacts with a protein kinase and a motor protein that display different expression patterns during plant development and infection.
  publication-title: Plant Cell
  doi: 10.1105/tpc.003681
  contributor:
    fullname: LJ Kong
– volume: 35
  start-page: 755
  year: 2006
  ident: ref32
  article-title: The 32 kDa subunit of replication protein A (RPA) participates in the DNA replication of Mung bean yellow mosaic India virus (MYMIV) by interacting with the viral Rep protein.
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkl1088
  contributor:
    fullname: DK Singh
– volume: 11
  start-page: 531
  year: 2010
  ident: ref7
  article-title: Tomato cultivar tolerant to Tomato leaf curl New Delhi virus infection induces virus-specific short interfering RNA accumulation and defence-associated host gene expression.
  publication-title: Mol Plant Pathol
  doi: 10.1111/j.1364-3703.2010.00630.x
  contributor:
    fullname: PP Sahu
– volume: 57
  start-page: 905
  year: 2008
  ident: ref36
  article-title: RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle.
  publication-title: Plant J
  doi: 10.1111/j.1365-313X.2008.03737.x
  contributor:
    fullname: J Lai
– volume: 51
  start-page: 997
  year: 2010
  ident: ref59
  article-title: Comparative transcriptomic profiling of a salt-tolerant wild tomato species and a salt-sensitive tomato cultivar.
  publication-title: Plant Cell Physiol
  doi: 10.1093/pcp/pcq056
  contributor:
    fullname: W Sun
– volume: 231
  start-page: 537
  year: 2010
  ident: ref28
  article-title: Tomato yellow leaf curl virus infection of a resistant tomato line with a silenced sucrose transporter gene LeHT1 results in inhibition of growth, enhanced virus spread, and necrosis.
  publication-title: Planta
  doi: 10.1007/s00425-009-1072-6
  contributor:
    fullname: A Eybishtz
– volume: 39
  start-page: 734
  year: 2004
  ident: ref24
  article-title: Applications and advantages of virus-induced gene silencing for gene function studies in plants.
  publication-title: Plant J
  doi: 10.1111/j.1365-313X.2004.02158.x
  contributor:
    fullname: TM Burch-Smith
– volume: 14
  start-page: 91
  year: 1998
  ident: ref17
  article-title: Gene silencing from plant DNA carried by a Geminivirus.
  publication-title: Plant Journal
  doi: 10.1046/j.1365-313X.1998.00101.x
  contributor:
    fullname: S Kjemtrup
– volume: 15
  start-page: 3020
  year: 2003
  ident: ref87
  article-title: Adenosine kinase is inactivated by geminivirus AL2 and L2 proteins.
  publication-title: Plant Cell
  doi: 10.1105/tpc.015180
  contributor:
    fullname: H Wang
– volume: 63
  start-page: 889
  year: 2010
  ident: ref42
  article-title: CLAVATA2 forms a distinct CLE-binding receptor complex regulating Arabidopsis stem cell specification.
  publication-title: Plant J
  doi: 10.1111/j.1365-313X.2010.04295.x
  contributor:
    fullname: Y Guo
– volume: 17
  start-page: 311
  year: 2005
  ident: ref83
  article-title: A NAC domain protein interacts with tomato leaf curl virus replication accessory protein and enhances viral replication.
  publication-title: Plant Cell
  doi: 10.1105/tpc.104.027235
  contributor:
    fullname: LA Selth
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Snippet Geminiviruses, like all viruses, rely on the host cell machinery to establish a successful infection, but the identity and function of these required host...
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StartPage e22383
SubjectTerms Analysis
Antiviral agents
Apium graveolens
Biology
Cloning, Molecular
Enzymes
Feasibility studies
Geminiviridae - physiology
Gene expression
Gene Silencing
Genes
Genes, Plant - genetics
Genetic Association Studies
Genetic engineering
Genetic research
Genetically modified plants
Genetics
Genomes
Green Fluorescent Proteins - metabolism
Health aspects
Host plants
Host-Pathogen Interactions - genetics
Infection
Infections
Kinases
Leaves
Machinery and equipment
Medical research
Molecular modelling
Nicotiana - genetics
Nicotiana - virology
Phenotype
Plant diseases
Plant Diseases - genetics
Plant Diseases - virology
Plant viruses
Plants, Genetically Modified
Proteins
Research parks
Reverse Genetics - methods
Studies
Tobacco
Tomatoes
Transgenic plants
Viral infections
Viruses
Yellow leaf
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Title Identification of host genes involved in geminivirus infection using a reverse genetics approach
URI https://www.ncbi.nlm.nih.gov/pubmed/21818318
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https://pubmed.ncbi.nlm.nih.gov/PMC3144222
https://doaj.org/article/e25b376095fe449ba4b68c67e3afbdb3
http://dx.doi.org/10.1371/journal.pone.0022383
Volume 6
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