Biased Use of the IGHV4 Family and Evidence for Antigen Selection in Chlamydophila psittaci-Negative Ocular Adnexal Extranodal Marginal Zone Lymphomas

• Published in: PloS one Vol. 6; no. 12; p. e29114
• Main Authors: Zhu, Daxing, Lossos, Chen, Chapman-Fredricks, Jennifer R., Matthews, Julie M., Ikpatt, Offiong F., Ruiz, Phillip, Lossos, Izidore S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.12.2011; Public Library of Science (PLoS)
• Subjects: Amino acids; Antigens; Antigens, Bacterial - immunology; Apoptosis; B cells; B-cell receptor; Bacteria; Bias; Biology; Cancer; Chlamydophila psittaci; Chlamydophila psittaci - immunology; Criminal investigations; Deoxyribonucleic acid; Development and progression; DNA; Etiology; Evidence; Eye Neoplasms - microbiology; Gene sequencing; Genes; Genetic aspects; Helicobacter pylori; Hematology; Heterogeneity; Homology; Humans; Immunoglobulin Heavy Chains - genetics; Immunoglobulins; Infections; Lacrimal gland and Nasolacrimal duct; Leukemia; Lymphocytes B; Lymphoma; Lymphoma, B-Cell, Marginal Zone - microbiology; Medicine; Molecular Sequence Data; Mutation; Non-Hodgkin's lymphomas; Oncology; Pathogenesis; Pathology; Stimulation; Studies; Thyroid gland; Tumors; Florida; United States > US

Extranodal marginal zone lymphomas (EMZL) are the most common lymphomas in the ocular adnexa. The etiology and potential role for antigenic stimulation in these lymphomas are still controversial. We have examined IGHV gene usage and mutations in 67 Chlamydophila psittaci-negative ocular adnexal EMZL...