Detection of Perturbation Phases and Developmental Stages in Organisms from DNA Microarray Time Series Data

• Published in: PloS one Vol. 6; no. 12; p. e27948
• Main Authors: Rooman, Marianne, Albert, Jaroslav, Dehouck, Yves, Haye, Alexandre
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.12.2011; Public Library of Science (PLoS)
• Subjects: Animals; Biology; Breast cancer; Cell cycle; Ciona intestinalis; Cluster Analysis; Clustering; Comparative analysis; Deoxyribonucleic acid; Developmental stages; Diauxie; Distance measurement; DNA; DNA microarrays; Drosophila melanogaster; E coli; Escherichia coli; Eukaryotes; Extracellular matrix; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes; Genomics; Insects; Invariants; Molecular biology; Oligonucleotide Array Sequence Analysis - methods; Organisms; Oxidative stress; Phases; Regression analysis; Rodents; Saccharomyces cerevisiae; Statistics as Topic; Stress response; Time Factors; Time series; Transition points; Vinegar

Available DNA microarray time series that record gene expression along the developmental stages of multicellular eukaryotes, or in unicellular organisms subject to external perturbations such as stress and diauxie, are analyzed. By pairwise comparison of the gene expression profiles on the basis of...