Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection

• Published in: PloS one Vol. 6; no. 5; p. e20029
• Main Authors: Chang, Ya-Ting, Wu, Chih-Ching, Shyr, Yi-Ming, Chen, Tse-Ching, Hwang, Tsann-Long, Yeh, Ta-Sen, Chang, Kai-Ping, Liu, Hao-Ping, Liu, Yu-Ling, Tsai, Ming-Hung, Chang, Yu-Sun, Yu, Jau-Song
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.05.2011; Public Library of Science (PLoS)
• Subjects: Age; Antigens; Bioindicators; Biology; Biomarkers; Biomarkers, Tumor - blood; Blotting, Western; Cancer; Cancer diagnosis; Cancer screening; Carbohydrates; Cell Line, Tumor; Cloning; Colorectal cancer; Cytotoxicity; Datasets; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix Proteins - blood; Gene expression; Gene Expression Profiling; GPI-Linked Proteins - blood; Hospitals; Humans; Immunoassay; Immunohistochemistry; Intercellular Signaling Peptides and Proteins - blood; Ligands; Medical diagnosis; Medical prognosis; Medical research; Medicine; Melanoma; Mortality; mRNA; Ovarian cancer; Pancreatic cancer; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - genetics; Patients; Protein binding; Protein expression; Proteins; RNA; Secretome; Serum levels; Surgery; Throat cancer; Tissues; Transforming Growth Factor beta - blood; United States > US; Taiwan

To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for P...