Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection
To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for P...
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| Published in | PloS one Vol. 6; no. 5; p. e20029 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Public Library of Science
20.05.2011
Public Library of Science (PLoS) |
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| Abstract | To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues.
ULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9).
Immunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls.
Collectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening. |
|---|---|
| AbstractList | Background To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues. Methods ULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9). Results Immunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls. Conclusions Collectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening. To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues. ULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9). Immunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls. Collectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening. BackgroundTo discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues.MethodsULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9).ResultsImmunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls.ConclusionsCollectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening. To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues.BACKGROUNDTo discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues.ULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9).METHODSULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9).Immunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls.RESULTSImmunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls.Collectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening.CONCLUSIONSCollectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening. To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues. ULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9). Immunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls. Collectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening. Background To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues. Methods ULBP2 expression in PC tissues from 67 patients was studied by immunohistochemistry. ULBP2 serum levels in 154 PC patients and 142 healthy controls were measured by bead-based immunoassay, and the efficacy of serum ULBP2 for PC detection was compared with the widely used serological PC marker carbohydrate antigen 19-9 (CA 19-9). Results Immunohistochemical analyses revealed an elevated expression of ULPB2 in PC tissues compared with adjacent non-cancerous tissues. Meanwhile, the serum levels of ULBP2 among all PC patients (n = 154) and in early-stage cancer patients were significantly higher than those in healthy controls (p<0.0001). The combination of ULBP2 and CA 19-9 outperformed each marker alone in distinguishing PC patients from healthy individuals. Importantly, an analysis of the area under receiver operating characteristic curves showed that ULBP2 was superior to CA 19-9 in discriminating patients with early-stage PC from healthy controls. Conclusions Collectively, our results indicate that ULBP2 may represent a novel and useful serum biomarker for pancreatic cancer primary screening. |
| Audience | Academic |
| Author | Chang, Kai-Ping Chang, Yu-Sun Wu, Chih-Ching Shyr, Yi-Ming Chen, Tse-Ching Hwang, Tsann-Long Liu, Hao-Ping Yu, Jau-Song Chang, Ya-Ting Liu, Yu-Ling Yeh, Ta-Sen Tsai, Ming-Hung |
| AuthorAffiliation | 1 Graduate Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Taiwan 3 Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Tao-Yuan, Taiwan 6 Department of Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan The University of Kansas Medical Center, United States of America 2 Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan 7 Departments of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan 8 Department of Cell and Molecular Biology, Chang Gung University, Tao-Yuan, Taiwan 4 Divisions of General and Transplantation Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan 5 Department of Anatomical Pathology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan |
| AuthorAffiliation_xml | – name: 2 Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan – name: 8 Department of Cell and Molecular Biology, Chang Gung University, Tao-Yuan, Taiwan – name: 6 Department of Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan – name: 4 Divisions of General and Transplantation Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan – name: 5 Department of Anatomical Pathology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan – name: 3 Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Tao-Yuan, Taiwan – name: 1 Graduate Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Taiwan – name: 7 Departments of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan – name: The University of Kansas Medical Center, United States of America |
| Author_xml | – sequence: 1 givenname: Ya-Ting surname: Chang fullname: Chang, Ya-Ting – sequence: 2 givenname: Chih-Ching surname: Wu fullname: Wu, Chih-Ching – sequence: 3 givenname: Yi-Ming surname: Shyr fullname: Shyr, Yi-Ming – sequence: 4 givenname: Tse-Ching surname: Chen fullname: Chen, Tse-Ching – sequence: 5 givenname: Tsann-Long surname: Hwang fullname: Hwang, Tsann-Long – sequence: 6 givenname: Ta-Sen surname: Yeh fullname: Yeh, Ta-Sen – sequence: 7 givenname: Kai-Ping surname: Chang fullname: Chang, Kai-Ping – sequence: 8 givenname: Hao-Ping surname: Liu fullname: Liu, Hao-Ping – sequence: 9 givenname: Yu-Ling surname: Liu fullname: Liu, Yu-Ling – sequence: 10 givenname: Ming-Hung surname: Tsai fullname: Tsai, Ming-Hung – sequence: 11 givenname: Yu-Sun surname: Chang fullname: Chang, Yu-Sun – sequence: 12 givenname: Jau-Song surname: Yu fullname: Yu, Jau-Song |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21625447$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2011 Public Library of Science 2011 Chang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Chang et al. 2011 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: JSY CCW. Performed the experiments: YTC YLL MHT. Analyzed the data: YTC CCW JSY. Contributed reagents/materials/analysis tools: YMS TCC TLH TSY KPC HPL YSC. Wrote the paper: YTC CCW JSY. |
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| Snippet | To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was... Background To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2)... BackgroundTo discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2)... Background To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2)... |
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| SubjectTerms | Age Antigens Bioindicators Biology Biomarkers Biomarkers, Tumor - blood Blotting, Western Cancer Cancer diagnosis Cancer screening Carbohydrates Cell Line, Tumor Cloning Colorectal cancer Cytotoxicity Datasets Enzyme-Linked Immunosorbent Assay Extracellular Matrix Proteins - blood Gene expression Gene Expression Profiling GPI-Linked Proteins - blood Hospitals Humans Immunoassay Immunohistochemistry Intercellular Signaling Peptides and Proteins - blood Ligands Medical diagnosis Medical prognosis Medical research Medicine Melanoma Mortality mRNA Ovarian cancer Pancreatic cancer Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - genetics Patients Protein binding Protein expression Proteins RNA Secretome Serum levels Surgery Throat cancer Tissues Transforming Growth Factor beta - blood |
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| Title | Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection |
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