Vancomycin heteroresistance is associated with reduced mortality in ST239 methicillin-resistant Staphylococcus aureus blood stream infections

• Published in: PloS one Vol. 6; no. 6; p. e21217
• Main Authors: van Hal, Sebastiaan J, Jones, Mark, Gosbell, Iain B, Paterson, David L
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.06.2011; Public Library of Science (PLoS)
• Subjects: 21st century; Aged; Analysis; Antibiotics; Antimicrobial agents; Australia; Bacteremia - drug therapy; Bacteremia - mortality; Chronic kidney failure; Clinical outcomes; Comorbidity; Demographics; Demography; Drug resistance; Health aspects; Hemodialysis; Humans; Infection; Infections; Infectious diseases; Kaplan-Meier Estimate; Kidneys; Laboratories; Male; Medical records; Medical research; Medicine; Methicillin; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - pathogenicity; Microbial drug resistance; Microbiology; Middle Aged; Minimum inhibitory concentration; Mortality; Multivariate analysis; Patients; Renal failure; Reviews; Staphylococcal Infections - drug therapy; Staphylococcal Infections - mortality; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; Surgery; Surveillance; Survival; Treatment Outcome; Vancomycin; Vancomycin - pharmacology; Vancomycin - therapeutic use; Vancomycin Resistance - drug effects; Australia; Queensland Australia; New South Wales Australia

Despite hVISA infections being associated with vancomycin treatment failure, no previous study has been able to detect a mortality difference between heteroresistant vancomycin intermediate Staphylococcus aureus (hVISA) and vancomycin susceptible Staphylococcus aureus (VSSA) bloodstream infections (...