Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothe...
Saved in:
| Published in | PloS one Vol. 6; no. 12; p. e28032 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
01.12.2011
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha-synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects.
Clinicaltrials.gov NCT01155492. |
|---|---|
| AbstractList | Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha-synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha-synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Trial Registration Clinicaltrials.gov NCT01155492 Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha-synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects.Clinicaltrials.gov NCT01155492. Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha–synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Trial Registration Clinicaltrials.gov NCT01155492 Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha-synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects. Clinicaltrials.gov NCT01155492. Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha-synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects.UNLABELLEDParkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothesis that the intestine might be an early site of PD disease in response to an environmental toxin or pathogen. One potential mechanism for environmental toxin(s) and proinflammatory luminal products to gain access to mucosal neuronal tissue and promote oxidative stress is compromised intestinal barrier integrity. However, the role of intestinal permeability in PD has never been tested. We hypothesized that PD subjects might exhibit increased intestinal permeability to proinflammatory bacterial products in the intestine. To test our hypothesis we evaluated intestinal permeability in subjects newly diagnosed with PD and compared their values to healthy subjects. In addition, we obtained intestinal biopsies from both groups and used immunohistochemistry to assess bacterial translocation, nitrotyrosine (oxidative stress), and alpha-synuclein. We also evaluated serum markers of endotoxin exposure including LPS binding protein (LBP). Our data show that our PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls. In addition, this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects. These data represent not only the first demonstration of abnormal intestinal permeability in PD subjects but also the first correlation of increased intestinal permeability in PD with intestinal alpha-synuclein (the hallmark of PD), as well as staining for gram negative bacteria and tissue oxidative stress. Our study may thus shed new light on PD pathogenesis as well as provide a new method for earlier diagnosis of PD and suggests potential therapeutic targets in PD subjects.Clinicaltrials.gov NCT01155492.TRIAL REGISTRATIONClinicaltrials.gov NCT01155492. |
| Audience | Academic |
| Author | Shaikh, Maliha Estes, Jacob D. Forsyth, Christopher B. Kordower, Jeffrey H. Jaglin, Jean A. Voigt, Robin M. Dodiya, Hemraj B. Keshavarzian, Ali Shannon, Kathleen M. |
| AuthorAffiliation | University Hospital La Paz, Spain 1 Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America 2 Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America 3 Center for Brain Repair, Rush Medical College, Chicago, Illinois, United States of America 4 AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America |
| AuthorAffiliation_xml | – name: University Hospital La Paz, Spain – name: 4 AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America – name: 3 Center for Brain Repair, Rush Medical College, Chicago, Illinois, United States of America – name: 1 Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Chicago, Illinois, United States of America – name: 2 Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America |
| Author_xml | – sequence: 1 givenname: Christopher B. surname: Forsyth fullname: Forsyth, Christopher B. – sequence: 2 givenname: Kathleen M. surname: Shannon fullname: Shannon, Kathleen M. – sequence: 3 givenname: Jeffrey H. surname: Kordower fullname: Kordower, Jeffrey H. – sequence: 4 givenname: Robin M. surname: Voigt fullname: Voigt, Robin M. – sequence: 5 givenname: Maliha surname: Shaikh fullname: Shaikh, Maliha – sequence: 6 givenname: Jean A. surname: Jaglin fullname: Jaglin, Jean A. – sequence: 7 givenname: Jacob D. surname: Estes fullname: Estes, Jacob D. – sequence: 8 givenname: Hemraj B. surname: Dodiya fullname: Dodiya, Hemraj B. – sequence: 9 givenname: Ali surname: Keshavarzian fullname: Keshavarzian, Ali |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22145021$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk99u0zAUxiM0xP7AGyCwhMTERYvtpEm8C6SpDKi0aRMFbq0T22k9XLvYDrQPwvvisG5qpwmhXCT-_DvfOT7xOcz2rLMqy54TPCR5Rd5eu85bMMNlkocY0xrn9FF2QFhOByXF-d7W9352GMI1xqO8Lssn2T6lpBhhSg6y3xMrvIKgJJrYqELUyRNdKb9Q0Gij4xqNnffKQNpEv3Sco6meLZyW6KITLgACs5zDYLq2nTBKWzSNoK22MwRWojMrXXSrJJ-tli50XqEL8N-VD6jXwJs1ukqCtsHZ44De69AX8zR73IIJ6tnmfZR9_XD2ZfxpcH75cTI-PR-IkpE4UISJoqmLijVtKzFuVEMZUzhnKmdVWdeylbJlNTBZtSNFGSmhANo0aZkXDc2Pspc3vkvjAt90NHCSE5KXo1FRJmJyQ0gH13zp9QL8mjvQ_K_g_IyDjzodndcCqKglyLKkhZSyIVC2FSNSKsAVQPJ6t8nWNQslhbLRg9kx3d2xes5n7ifPKa0r2pd7vDHw7keXfhZf6CCUMWCV6wJnmNG6xqMika_ukQ8fbkPNINWvbetSWtF78tMi9a8klOFEDR-g0iPVQot0-1qd9J2ANzsBiYlqFWfQhcAn08__z15-22Vfb7FzBSbOgzNd1M6GXfDFdqPvOnx77RNQ3ADCuxC8au8Qgnk_Xbft4v108c10pbCTe2FCR-jTp45o8-_gP4_jLrQ |
| CitedBy_id | crossref_primary_10_1007_s00702_023_02635_4 crossref_primary_10_1515_revneuro_2018_0024 crossref_primary_10_1093_ibd_izae232 crossref_primary_10_3390_antiox11112141 crossref_primary_10_3390_nu16172946 crossref_primary_10_2217_bmm_2020_0654 crossref_primary_10_7759_cureus_73150 crossref_primary_10_1097_MCG_0000000000000965 crossref_primary_10_3389_fbioe_2019_00435 crossref_primary_10_1002_imo2_33 crossref_primary_10_1186_s12974_022_02510_1 crossref_primary_10_3233_JPD_191711 crossref_primary_10_1111_febs_17102 crossref_primary_10_1007_s00018_023_04819_3 crossref_primary_10_1016_S2468_1253_22_00241_2 crossref_primary_10_3389_fnmol_2024_1379726 crossref_primary_10_1042_CS20150046 crossref_primary_10_1007_s00401_017_1777_8 crossref_primary_10_1212_WNL_0000000000004496 crossref_primary_10_1002_ana_26719 crossref_primary_10_1002_jgh3_12450 crossref_primary_10_1016_j_biopha_2019_109040 crossref_primary_10_1016_j_bbih_2020_100060 crossref_primary_10_1007_s11481_024_10115_z crossref_primary_10_1124_pharmrev_122_000743 crossref_primary_10_1128_CMR_00338_20 crossref_primary_10_3233_JPD_191707 crossref_primary_10_1007_s00702_021_02445_6 crossref_primary_10_3390_cells8030222 crossref_primary_10_1016_j_xcrm_2025_101982 crossref_primary_10_1038_s41531_021_00170_1 crossref_primary_10_3233_JPD_230021 crossref_primary_10_1007_s10787_024_01510_2 crossref_primary_10_1007_s11064_020_03187_9 crossref_primary_10_1042_EBC20220062 crossref_primary_10_1016_j_parkreldis_2014_02_019 crossref_primary_10_1016_j_arr_2021_101347 crossref_primary_10_1016_j_parkreldis_2018_11_014 crossref_primary_10_1186_s40035_021_00271_0 crossref_primary_10_2174_0118715273264097231116103948 crossref_primary_10_1038_s41531_016_0002_0 crossref_primary_10_1016_j_jff_2020_104176 crossref_primary_10_3389_fneur_2019_00574 crossref_primary_10_1016_j_ecoenv_2022_114152 crossref_primary_10_1016_j_neuroscience_2020_02_030 crossref_primary_10_3390_jcm10030493 crossref_primary_10_3390_jpm12020144 crossref_primary_10_1016_j_nut_2020_111090 crossref_primary_10_1038_s41531_022_00289_9 crossref_primary_10_3389_fnins_2020_614331 crossref_primary_10_2174_1871527321666220822172039 crossref_primary_10_1134_S036211971908005X crossref_primary_10_3389_fcimb_2020_00297 crossref_primary_10_1371_journal_pone_0251604 crossref_primary_10_1002_mnfr_202300461 crossref_primary_10_3390_nu16132041 crossref_primary_10_1096_fasebj_2018_32_1_supplement_545_19 crossref_primary_10_1177_08919887211018268 crossref_primary_10_1016_j_neuint_2018_08_005 crossref_primary_10_3233_JPD_191802 crossref_primary_10_3390_ijms21207551 crossref_primary_10_3233_JPD_240195 crossref_primary_10_1038_s41531_017_0017_1 crossref_primary_10_1038_s41598_018_19646_x crossref_primary_10_1371_journal_pgen_1011063 crossref_primary_10_4291_wjgp_v11_i6_114 crossref_primary_10_1016_j_gastha_2022_03_007 crossref_primary_10_1080_20002297_2023_2250650 crossref_primary_10_3389_fnana_2015_00032 crossref_primary_10_3390_cells9020376 crossref_primary_10_1038_s41531_021_00191_w crossref_primary_10_1186_s13024_021_00427_6 crossref_primary_10_3390_ijms25031747 crossref_primary_10_1016_j_arr_2018_04_004 crossref_primary_10_1007_s12035_024_04151_2 crossref_primary_10_1038_s41531_019_0100_x crossref_primary_10_1007_s12041_018_0960_6 crossref_primary_10_1038_s41598_022_20261_0 crossref_primary_10_1073_pnas_1215849110 crossref_primary_10_1089_ars_2019_7997 crossref_primary_10_1111_cmi_12585 crossref_primary_10_1136_gutjnl_2018_316844 crossref_primary_10_1097_YPG_0000000000000255 crossref_primary_10_1093_ptj_pzac022 crossref_primary_10_1111_brv_12407 crossref_primary_10_2217_nmt_15_38 crossref_primary_10_1016_j_parkreldis_2021_11_017 crossref_primary_10_25692_ACEN_2020_1_7 crossref_primary_10_3390_ijms221810028 crossref_primary_10_3389_fneur_2022_831090 crossref_primary_10_1016_j_mehy_2019_109436 crossref_primary_10_3389_fnins_2019_00992 crossref_primary_10_1016_j_bbi_2017_05_009 crossref_primary_10_1016_j_parkreldis_2018_02_022 crossref_primary_10_1038_s41531_023_00511_2 crossref_primary_10_1016_j_micinf_2021_104816 crossref_primary_10_3390_jpm12010049 crossref_primary_10_1016_j_parkreldis_2020_10_034 crossref_primary_10_1186_s13099_023_00536_1 crossref_primary_10_3390_biomedicines10030596 crossref_primary_10_3280_PNEI2022_002004 crossref_primary_10_3389_fneur_2019_00663 crossref_primary_10_1212_WNL_0000000000003127 crossref_primary_10_3390_cells10051111 crossref_primary_10_3389_fnagi_2023_1151850 crossref_primary_10_1007_s10571_021_01117_z crossref_primary_10_3389_fnagi_2021_671142 crossref_primary_10_1186_s13568_020_01014_6 crossref_primary_10_1177_1073858421992265 crossref_primary_10_3390_microorganisms6020035 crossref_primary_10_1016_j_neurol_2023_11_004 crossref_primary_10_1002_brb3_2226 crossref_primary_10_1007_s11910_018_0889_4 crossref_primary_10_1152_ajpgi_00103_2017 crossref_primary_10_1021_acs_chemrestox_4c00057 crossref_primary_10_1155_2018_4784268 crossref_primary_10_3390_ijms222413177 crossref_primary_10_3389_fcimb_2020_570658 crossref_primary_10_1186_s12866_023_02933_7 crossref_primary_10_2139_ssrn_4010898 crossref_primary_10_3390_antiox11010141 crossref_primary_10_3389_fmicb_2022_959856 crossref_primary_10_1007_s11481_012_9402_z crossref_primary_10_3390_life11080855 crossref_primary_10_3390_microorganisms8111661 crossref_primary_10_3389_fneur_2019_00652 crossref_primary_10_1016_j_mehy_2015_08_018 crossref_primary_10_1152_physrev_00018_2018 crossref_primary_10_1124_pharmrev_122_000674 crossref_primary_10_1111_nmo_12070 crossref_primary_10_1016_j_neuropharm_2024_110278 crossref_primary_10_1002_ana_25982 crossref_primary_10_3389_fcimb_2022_886872 crossref_primary_10_1007_s11011_021_00808_2 crossref_primary_10_1093_braincomms_fcae098 crossref_primary_10_7759_cureus_44819 crossref_primary_10_1186_s12974_019_1564_7 crossref_primary_10_1016_j_bbi_2015_01_009 crossref_primary_10_1038_s41598_024_65061_w crossref_primary_10_3389_fnagi_2021_819373 crossref_primary_10_3233_JAD_220176 crossref_primary_10_3389_fneur_2021_729961 crossref_primary_10_1186_s12929_022_00839_6 crossref_primary_10_1007_s44169_023_00034_0 crossref_primary_10_1016_j_brainresbull_2023_110668 crossref_primary_10_1186_s12974_016_0766_5 crossref_primary_10_3390_cells12071012 crossref_primary_10_3390_jcm10030459 crossref_primary_10_3390_life13030805 crossref_primary_10_1002_jcb_25302 crossref_primary_10_1016_j_bbr_2019_02_039 crossref_primary_10_1055_s_0043_1771468 crossref_primary_10_1016_j_bbi_2024_02_007 crossref_primary_10_3389_fimmu_2019_00969 crossref_primary_10_1186_s40478_015_0196_0 crossref_primary_10_1055_s_0043_1771464 crossref_primary_10_18632_oncotarget_17754 crossref_primary_10_3233_JPD_191729 crossref_primary_10_1186_s40035_024_00404_1 crossref_primary_10_1016_j_phrs_2020_104928 crossref_primary_10_1038_s41531_020_0112_6 crossref_primary_10_3390_ijms22136737 crossref_primary_10_1128_CMR_00050_12 crossref_primary_10_1089_ars_2014_5859 crossref_primary_10_3233_JPD_230206 crossref_primary_10_3389_fnins_2021_756951 crossref_primary_10_3389_fimmu_2019_00239 crossref_primary_10_1007_s00415_019_09320_1 crossref_primary_10_1016_j_brainres_2012_04_014 crossref_primary_10_1002_mds_25966 crossref_primary_10_4274_tjps_galenos_2021_95226 crossref_primary_10_3389_fneur_2020_00787 crossref_primary_10_1038_s41575_023_00890_0 crossref_primary_10_3389_fimmu_2022_785644 crossref_primary_10_5056_jnm19044 crossref_primary_10_3390_ijms19061689 crossref_primary_10_1021_acschemneuro_0c00475 crossref_primary_10_1007_s10620_015_3698_5 crossref_primary_10_14336_AD_2021_0418 crossref_primary_10_3389_fmicb_2020_562048 crossref_primary_10_1038_s41531_021_00244_0 crossref_primary_10_1038_s12276_020_00505_7 crossref_primary_10_1186_s12934_020_01313_4 crossref_primary_10_1007_s00115_018_0601_6 crossref_primary_10_1039_D4LC00896K crossref_primary_10_11603_1681_2727_2024_4_14688 crossref_primary_10_1016_j_actbio_2021_05_045 crossref_primary_10_1136_bmjopen_2022_071380 crossref_primary_10_3390_ijms24119577 crossref_primary_10_1016_j_chemphyslip_2020_105029 crossref_primary_10_1016_j_tifs_2023_04_005 crossref_primary_10_3390_biom11030433 crossref_primary_10_1016_j_nbd_2018_10_007 crossref_primary_10_5455_bcp_20160531111208 crossref_primary_10_1177_0148607113501881 crossref_primary_10_3389_fnagi_2021_782082 crossref_primary_10_1371_journal_pone_0218252 crossref_primary_10_3390_ijms20174121 crossref_primary_10_1016_j_neuroscience_2014_10_028 crossref_primary_10_1038_s41598_018_29173_4 crossref_primary_10_3389_fnins_2023_1281710 crossref_primary_10_1007_s12035_012_8267_8 crossref_primary_10_1016_j_toxlet_2021_12_003 crossref_primary_10_1111_nmo_12797 crossref_primary_10_1007_s10286_020_00745_7 crossref_primary_10_37349_ent_2023_00049 crossref_primary_10_3389_fnins_2019_00839 crossref_primary_10_1007_s40265_021_01664_1 crossref_primary_10_1007_s00702_015_1443_z crossref_primary_10_1080_01616412_2016_1249997 crossref_primary_10_3389_fimmu_2023_1154626 crossref_primary_10_3389_fnut_2022_843096 crossref_primary_10_14271_DMS_21333_DE crossref_primary_10_1007_s11596_015_1522_2 crossref_primary_10_3389_fnins_2020_580311 crossref_primary_10_3389_fnins_2015_00306 crossref_primary_10_3390_applmicrobiol3020030 crossref_primary_10_3389_fmicb_2022_875101 crossref_primary_10_1186_s13024_023_00628_1 crossref_primary_10_3389_fimmu_2020_00575 crossref_primary_10_4103_NRR_NRR_D_24_00994 crossref_primary_10_1007_s12035_013_8553_0 crossref_primary_10_1186_s12974_023_02846_2 crossref_primary_10_1002_mds_26942 crossref_primary_10_3233_JPD_230315 crossref_primary_10_1128_mSystems_00797_20 crossref_primary_10_1002_mds_26702 crossref_primary_10_1186_s12974_021_02280_2 crossref_primary_10_14336_AD_2024_1362 crossref_primary_10_3389_fneur_2021_794640 crossref_primary_10_1002_mds_25736 crossref_primary_10_1007_s00391_012_0414_3 crossref_primary_10_3389_fnins_2019_00728 crossref_primary_10_1002_mds_25979 crossref_primary_10_1038_s41531_022_00428_2 crossref_primary_10_3389_fneur_2022_945523 crossref_primary_10_1016_j_brainres_2021_147609 crossref_primary_10_14412_2074_2711_2023_1_90_96 crossref_primary_10_3389_fnagi_2022_842380 crossref_primary_10_1007_s10072_024_07641_2 crossref_primary_10_1111_cns_13916 crossref_primary_10_3390_nu14071467 crossref_primary_10_1177_1721727X221083763 crossref_primary_10_1016_j_jnutbio_2018_04_004 crossref_primary_10_3390_ijms19123810 crossref_primary_10_1002_bit_27816 crossref_primary_10_3389_fimmu_2015_00223 crossref_primary_10_1007_s12264_022_00848_3 crossref_primary_10_1080_00207233_2024_2425557 crossref_primary_10_1016_j_bbi_2020_07_036 crossref_primary_10_1186_s40478_021_01240_4 crossref_primary_10_2174_1381612828666221003112300 crossref_primary_10_1016_j_celrep_2021_108807 crossref_primary_10_36106_ijsr_6907898 crossref_primary_10_1038_s41467_022_34667_x crossref_primary_10_3233_JAD_170020 crossref_primary_10_3390_ijms232012289 crossref_primary_10_1016_j_biopha_2024_117101 crossref_primary_10_1016_S1474_4422_19_30356_4 crossref_primary_10_1016_j_banm_2019_11_013 crossref_primary_10_14336_AD_2022_01281 crossref_primary_10_1016_j_pnpbp_2023_110861 crossref_primary_10_1371_journal_pone_0067102 crossref_primary_10_3748_wjg_v26_i14_1564 crossref_primary_10_61186_sjku_29_3_11 crossref_primary_10_3389_fimmu_2019_00303 crossref_primary_10_37496_rbz4920190096 crossref_primary_10_1002_mds_27815 crossref_primary_10_1126_scisignal_2005375 crossref_primary_10_1002_ana_24901 crossref_primary_10_1016_j_pneurobio_2020_101905 crossref_primary_10_1016_j_aimed_2014_12_007 crossref_primary_10_3389_fphar_2022_1007654 crossref_primary_10_1038_nrneurol_2012_6 crossref_primary_10_1007_s10072_018_3641_6 crossref_primary_10_1186_s40035_023_00392_8 crossref_primary_10_1016_j_neuropharm_2021_108839 crossref_primary_10_1007_s00415_017_8639_0 crossref_primary_10_1038_s41598_018_35009_y crossref_primary_10_1016_j_neubiorev_2020_02_003 crossref_primary_10_3389_fcimb_2024_1348279 crossref_primary_10_1016_j_cub_2017_01_035 crossref_primary_10_3389_fnins_2022_1030694 crossref_primary_10_1021_acsomega_8b03590 crossref_primary_10_1021_acsptsci_2c00104 crossref_primary_10_3390_medicina58010084 crossref_primary_10_17116_jnevro2016116111174_179 crossref_primary_10_1016_j_neuint_2024_105803 crossref_primary_10_1155_2020_4518023 crossref_primary_10_12677_ACM_2024_141154 crossref_primary_10_1111_nmo_14780 crossref_primary_10_1155_2014_152428 crossref_primary_10_1016_j_isci_2024_110980 crossref_primary_10_1007_s12275_018_8032_4 crossref_primary_10_1007_s00401_012_1040_2 crossref_primary_10_3389_fnins_2020_00626 crossref_primary_10_1089_photob_2021_0056 crossref_primary_10_1136_bmjopen_2018_025574 crossref_primary_10_17116_jnevro202112110286 crossref_primary_10_2147_NDT_S367016 crossref_primary_10_1016_j_neuro_2021_05_015 crossref_primary_10_1007_s00401_018_1856_5 crossref_primary_10_1186_s12877_018_0767_6 crossref_primary_10_1136_bmjopen_2021_053336 crossref_primary_10_1016_j_parkreldis_2024_107081 crossref_primary_10_1016_j_cca_2014_12_040 crossref_primary_10_1177_24705470221076390 crossref_primary_10_1007_s12264_022_00934_6 crossref_primary_10_1016_j_jneuroim_2019_01_004 crossref_primary_10_1002_mds_25895 crossref_primary_10_18231_j_ijnmhs_2020_015 crossref_primary_10_18499_2225_7357_2018_7_4_61_66 crossref_primary_10_3389_fnbeh_2018_00140 crossref_primary_10_1172_JCI143775 crossref_primary_10_4103_1673_5374_317981 crossref_primary_10_3389_fcimb_2021_652617 crossref_primary_10_3109_00207454_2015_1096271 crossref_primary_10_1186_s12974_023_02720_1 crossref_primary_10_1038_s41575_020_00385_2 crossref_primary_10_1038_s41598_020_75229_9 crossref_primary_10_1177_1073858420943180 crossref_primary_10_3389_fnagi_2020_00026 crossref_primary_10_1080_15548627_2023_2172873 crossref_primary_10_3390_brainsci10040206 crossref_primary_10_1002_mdc3_70029 crossref_primary_10_3233_JPD_181477 crossref_primary_10_1038_srep32826 crossref_primary_10_1590_0004_282x20170188 crossref_primary_10_3382_ps_pez456 crossref_primary_10_1080_07853890_2021_1890330 crossref_primary_10_3166_dea_2021_0167 crossref_primary_10_3233_JPD_160991 crossref_primary_10_1016_S1474_4422_15_00007_1 crossref_primary_10_1002_nur_22209 crossref_primary_10_1016_j_neuron_2019_05_035 crossref_primary_10_1053_j_gastro_2012_06_034 crossref_primary_10_1016_j_neuropharm_2021_108721 crossref_primary_10_1016_j_parkreldis_2018_06_003 crossref_primary_10_30699_ijmm_13_1_1 crossref_primary_10_3390_molecules29112614 crossref_primary_10_1016_j_biopha_2021_111661 crossref_primary_10_3389_fmicb_2022_791213 crossref_primary_10_1007_s12223_022_00977_2 crossref_primary_10_1007_s00115_012_3575_9 crossref_primary_10_1186_s12974_022_02584_x crossref_primary_10_1016_j_jfma_2022_09_010 crossref_primary_10_3389_fnins_2021_708587 crossref_primary_10_1111_nyas_13416 crossref_primary_10_3390_cells9081909 crossref_primary_10_1111_ane_13570 crossref_primary_10_1002_gps_4274 crossref_primary_10_1007_s11481_021_10041_4 crossref_primary_10_1007_s13760_023_02195_0 crossref_primary_10_1016_j_neurol_2022_12_010 crossref_primary_10_1038_nn_4476 crossref_primary_10_1007_s11011_013_9412_4 crossref_primary_10_1111_ejn_15892 crossref_primary_10_3390_brainsci11070831 crossref_primary_10_1038_s41598_023_29219_2 crossref_primary_10_1007_s13311_020_00942_2 crossref_primary_10_1111_1462_2920_14506 crossref_primary_10_3390_ijms22158022 crossref_primary_10_1155_2020_8456596 crossref_primary_10_1016_j_parkreldis_2016_03_012 crossref_primary_10_3389_fcimb_2024_1421270 crossref_primary_10_1007_s11910_012_0283_6 crossref_primary_10_1016_j_celrep_2024_113865 crossref_primary_10_1002_med_21584 crossref_primary_10_1007_s00005_019_00561_6 crossref_primary_10_3390_biom11020144 crossref_primary_10_1007_s12035_021_02500_z crossref_primary_10_3389_fcimb_2023_1296713 crossref_primary_10_3390_life11070698 crossref_primary_10_1016_j_nbd_2018_12_012 crossref_primary_10_1186_s12974_020_1705_z crossref_primary_10_1007_s12035_023_03679_z crossref_primary_10_1186_s41983_021_00407_z crossref_primary_10_1007_s13311_017_0601_4 crossref_primary_10_3390_jcm9113705 crossref_primary_10_1007_s12640_023_00681_0 crossref_primary_10_1016_j_nbd_2015_05_017 crossref_primary_10_1016_j_cellimm_2018_02_011 crossref_primary_10_3389_fnagi_2022_955919 crossref_primary_10_1080_07924259_2014_963713 crossref_primary_10_3233_JPD_150736 crossref_primary_10_1002_mds_26307 crossref_primary_10_3390_biomedicines12081738 crossref_primary_10_1096_fj_201900071R crossref_primary_10_3920_BM2017_0202 crossref_primary_10_2217_nmt_2015_0012 crossref_primary_10_1016_j_jare_2022_10_013 crossref_primary_10_1016_j_neurobiolaging_2016_08_019 crossref_primary_10_1016_j_ejps_2023_106452 crossref_primary_10_1038_s41579_020_00460_0 crossref_primary_10_1111_nan_12298 crossref_primary_10_2174_1381612826666201211112846 crossref_primary_10_1002_ana_26128 crossref_primary_10_3389_fnagi_2021_702639 crossref_primary_10_1038_nrneurol_2015_197 crossref_primary_10_1016_j_parkreldis_2018_05_007 crossref_primary_10_14802_jmd_18067 crossref_primary_10_3390_diagnostics15060719 crossref_primary_10_3390_microorganisms12040634 crossref_primary_10_1016_j_bbi_2020_01_018 crossref_primary_10_1016_j_bbrc_2021_03_109 crossref_primary_10_1111_apt_12950 crossref_primary_10_2139_ssrn_4109842 crossref_primary_10_3892_mmr_2021_12374 crossref_primary_10_1007_s00415_022_11461_9 crossref_primary_10_1186_s13073_017_0428_y crossref_primary_10_3390_nu15112505 crossref_primary_10_1111_ene_13398 crossref_primary_10_1371_journal_pone_0208313 crossref_primary_10_3390_medsci9010017 crossref_primary_10_1021_acsami_4c08864 crossref_primary_10_1098_rstb_2022_0381 crossref_primary_10_3390_nu7010017 crossref_primary_10_1016_j_biopha_2018_05_107 crossref_primary_10_1016_j_neurobiolaging_2016_08_004 crossref_primary_10_3390_biology12010093 crossref_primary_10_5056_jnm17105 crossref_primary_10_1136_bmjopen_2023_071766 crossref_primary_10_3390_nu13010028 crossref_primary_10_7554_eLife_81453 crossref_primary_10_3390_nu12051287 crossref_primary_10_1002_jsfa_13509 crossref_primary_10_3389_fcell_2021_673395 crossref_primary_10_1007_s11357_024_01451_2 crossref_primary_10_1080_14737175_2020_1775585 crossref_primary_10_1007_s10072_018_3502_3 crossref_primary_10_3233_JPD_202459 crossref_primary_10_1007_s12035_023_03545_y crossref_primary_10_1016_j_bpg_2019_101636 crossref_primary_10_3233_JPD_202330 crossref_primary_10_1016_j_jad_2021_07_021 crossref_primary_10_1016_j_bas_2022_101188 crossref_primary_10_1038_s41531_022_00295_x crossref_primary_10_2174_0929867325666181009161048 crossref_primary_10_1371_journal_pone_0187307 crossref_primary_10_7554_eLife_53111 crossref_primary_10_2144_fsoa_2019_0035 crossref_primary_10_1016_j_nbd_2019_104704 crossref_primary_10_1038_s41531_020_00145_8 crossref_primary_10_1016_j_heliyon_2020_e05771 crossref_primary_10_1016_j_neures_2021_01_001 crossref_primary_10_1155_2016_5436738 crossref_primary_10_1002_mds_26116 crossref_primary_10_1016_j_ensci_2020_100270 crossref_primary_10_1002_mds_27326 crossref_primary_10_1016_j_neuropharm_2023_109573 crossref_primary_10_3389_fimmu_2022_878771 crossref_primary_10_3390_ijms25137006 crossref_primary_10_1007_s40473_017_0129_2 crossref_primary_10_3389_fimmu_2022_937555 crossref_primary_10_1002_mds_28411 crossref_primary_10_3233_JPD_202341 crossref_primary_10_1016_j_nbd_2021_105601 crossref_primary_10_1016_j_neulet_2019_04_004 crossref_primary_10_1002_mds_28890 crossref_primary_10_1038_s41531_022_00328_5 crossref_primary_10_1152_ajpgi_00058_2020 crossref_primary_10_1159_000488629 crossref_primary_10_1016_j_brainres_2019_146460 crossref_primary_10_1186_s40168_018_0494_4 crossref_primary_10_1016_j_jneuroim_2020_577390 crossref_primary_10_1016_j_mocell_2024_100161 crossref_primary_10_1016_j_neuropharm_2023_109566 crossref_primary_10_1038_s41467_023_38248_4 crossref_primary_10_3389_fneur_2022_882628 crossref_primary_10_1136_pn_2024_004400 crossref_primary_10_3390_biomedicines11082089 crossref_primary_10_1016_j_bbi_2021_02_028 crossref_primary_10_1586_14737175_2015_1095093 crossref_primary_10_1002_mds_27556 crossref_primary_10_2174_1570159X18666200606233050 crossref_primary_10_1093_brain_awab156 crossref_primary_10_1038_s41531_024_00724_z crossref_primary_10_1016_j_nbd_2021_105599 crossref_primary_10_1016_j_jns_2022_120166 crossref_primary_10_3390_antiox12050988 crossref_primary_10_1007_s40263_024_01073_4 crossref_primary_10_1111_cogs_12070 crossref_primary_10_1016_j_nbd_2012_09_007 crossref_primary_10_1016_j_parkreldis_2016_08_019 crossref_primary_10_3389_fanim_2024_1507838 crossref_primary_10_12677_OJNS_2023_113040 crossref_primary_10_3389_fmed_2021_655123 crossref_primary_10_3748_wjg_v21_i37_10609 crossref_primary_10_3233_JPD_212574 crossref_primary_10_1186_s12890_018_0647_z crossref_primary_10_1097_QAD_0000000000000569 crossref_primary_10_14814_phy2_12356 crossref_primary_10_3233_JPD_223461 crossref_primary_10_1002_mds_26259 crossref_primary_10_2174_1871527319666200726222138 crossref_primary_10_2217_fnl_2020_0026 crossref_primary_10_1002_btm2_10351 crossref_primary_10_14814_phy2_13443 crossref_primary_10_1136_gutjnl_2019_318427 crossref_primary_10_1007_s00441_018_2856_4 crossref_primary_10_1111_jnc_14965 crossref_primary_10_3389_fphar_2019_01271 crossref_primary_10_3390_biom11010030 crossref_primary_10_1016_j_bbi_2017_06_017 crossref_primary_10_1177_1073858420918826 crossref_primary_10_1002_ana_26454 crossref_primary_10_1002_mds_27105 crossref_primary_10_1097_WCO_0000000000000349 crossref_primary_10_1002_mds_26258 crossref_primary_10_1016_j_parkreldis_2017_02_002 crossref_primary_10_3390_ijms232113328 crossref_primary_10_1002_mds_27581 crossref_primary_10_1016_j_neurot_2024_e00462 crossref_primary_10_3390_microorganisms10071428 crossref_primary_10_3390_brainsci11080959 crossref_primary_10_1007_s11011_018_0239_x crossref_primary_10_1111_all_16318 crossref_primary_10_1007_s13670_018_0240_6 crossref_primary_10_1007_s11064_024_04217_6 crossref_primary_10_3389_fnagi_2022_861035 crossref_primary_10_1002_mdc3_13407 crossref_primary_10_31146_1682_8658_ecg_214_6_100_104 crossref_primary_10_3390_ijms21041381 crossref_primary_10_1134_S0022093021040013 crossref_primary_10_3389_fimmu_2021_578386 crossref_primary_10_3390_nu14091952 crossref_primary_10_1111_jnc_15701 crossref_primary_10_3233_JPD_223338 crossref_primary_10_1097_MIB_0000000000000735 crossref_primary_10_3389_fneur_2019_01155 crossref_primary_10_3233_JPD_150557 crossref_primary_10_1016_j_cellimm_2014_04_001 crossref_primary_10_1016_j_tim_2022_01_004 crossref_primary_10_1038_s41583_021_00542_9 crossref_primary_10_3390_cells11060978 crossref_primary_10_1016_j_cca_2014_09_031 crossref_primary_10_1007_s00702_023_02630_9 crossref_primary_10_3233_JHD_240012 crossref_primary_10_3389_fphar_2024_1372110 crossref_primary_10_1007_s12017_020_08617_z crossref_primary_10_1177_1877718X241312401 crossref_primary_10_1007_s11011_022_00917_6 crossref_primary_10_1038_s41598_024_81020_x crossref_primary_10_1093_nutrit_nuae208 crossref_primary_10_1007_s10571_018_0589_2 crossref_primary_10_1021_acschemneuro_7b00373 crossref_primary_10_1080_1028415X_2017_1294555 crossref_primary_10_3233_JPD_223245 crossref_primary_10_1007_s11064_017_2334_5 crossref_primary_10_1016_j_neuro_2014_12_002 crossref_primary_10_1007_s10571_021_01066_7 crossref_primary_10_1016_j_ctcp_2018_02_014 crossref_primary_10_1016_j_nbd_2019_03_014 crossref_primary_10_1212_WNL_0000000000010998 crossref_primary_10_1186_s40478_016_0408_2 crossref_primary_10_4062_biomolther_2024_009 crossref_primary_10_1016_j_exger_2024_112444 crossref_primary_10_2217_epi_2023_0342 crossref_primary_10_1523_JNEUROSCI_1672_18_2018 crossref_primary_10_1002_mdc3_13621 crossref_primary_10_1007_s11940_018_0539_9 crossref_primary_10_3390_cells9112476 crossref_primary_10_1016_j_neurot_2024_e00476 crossref_primary_10_3390_microorganisms11041083 crossref_primary_10_3390_nu11081896 crossref_primary_10_3390_nu14020399 crossref_primary_10_1002_1873_3468_13038 crossref_primary_10_1155_2016_6762528 crossref_primary_10_1002_brb3_3130 crossref_primary_10_4103_1673_5374_290896 crossref_primary_10_3390_ijms19113573 crossref_primary_10_1016_j_lfs_2022_121356 crossref_primary_10_3389_fnins_2021_753915 crossref_primary_10_1007_s10068_016_0037_3 crossref_primary_10_3389_fnagi_2022_986127 crossref_primary_10_1016_j_bbi_2024_01_010 crossref_primary_10_1007_s12264_017_0179_1 crossref_primary_10_4103_AOMD_AOMD_4_18 crossref_primary_10_7759_cureus_19035 crossref_primary_10_1016_j_brainresbull_2022_02_015 crossref_primary_10_1002_mds_28119 crossref_primary_10_1097_WCO_0000000000000389 crossref_primary_10_1177_2049936120981526 crossref_primary_10_3389_fnagi_2020_603849 crossref_primary_10_3389_fneur_2019_01245 crossref_primary_10_3389_fcimb_2021_615075 crossref_primary_10_3390_app10051828 crossref_primary_10_3390_ijms252212164 crossref_primary_10_3390_nu14020380 crossref_primary_10_1007_s10048_024_00779_3 crossref_primary_10_18632_oncotarget_5895 crossref_primary_10_1016_j_ymeth_2024_10_009 crossref_primary_10_5812_ijpr_137840 crossref_primary_10_1016_j_expneurol_2012_12_008 crossref_primary_10_1007_s12035_024_04584_9 crossref_primary_10_3390_jcm10010005 crossref_primary_10_1007_s10072_025_08114_w crossref_primary_10_1126_scitranslmed_adk3225 crossref_primary_10_25692_ACEN_2018_4_3 crossref_primary_10_1007_s12975_019_00760_5 crossref_primary_10_3390_ijms22158338 crossref_primary_10_1002_mco2_656 crossref_primary_10_1038_s41531_021_00216_4 crossref_primary_10_1002_mds_29432 crossref_primary_10_1097_WCO_0000000000000496 crossref_primary_10_1038_s41467_023_36497_x crossref_primary_10_3390_biomedicines10092057 crossref_primary_10_3390_microorganisms10081544 crossref_primary_10_1016_j_cell_2016_10_027 crossref_primary_10_1016_j_yao_2023_01_007 crossref_primary_10_1371_journal_pone_0142164 crossref_primary_10_1111_febs_16558 crossref_primary_10_3389_fneur_2017_00037 crossref_primary_10_3233_JPD_223568 crossref_primary_10_3390_nu15081815 crossref_primary_10_1002_ana_26550 crossref_primary_10_1016_j_clinthera_2016_12_014 crossref_primary_10_1002_mdc3_12840 crossref_primary_10_1080_00365521_2019_1641739 crossref_primary_10_1002_mds_28016 crossref_primary_10_1016_j_nbd_2022_105744 crossref_primary_10_1292_jvms_16_0090 crossref_primary_10_1016_j_nbd_2020_105027 crossref_primary_10_3390_ijms25179489 crossref_primary_10_1038_s41582_022_00681_2 crossref_primary_10_3389_fnmol_2019_00171 crossref_primary_10_1155_2019_7535472 crossref_primary_10_1093_jnen_nlab046 crossref_primary_10_12938_bmfh_19_002 crossref_primary_10_1016_j_ejphar_2022_175029 crossref_primary_10_3389_fcimb_2020_00098 crossref_primary_10_1016_j_pharmthera_2021_107978 crossref_primary_10_1038_s41598_023_30698_6 crossref_primary_10_1093_nutrit_nuab024 crossref_primary_10_1007_s11377_019_0345_2 crossref_primary_10_1016_j_arr_2021_101396 crossref_primary_10_1038_mt_2015_7 crossref_primary_10_1111_febs_15217 crossref_primary_10_1371_journal_pone_0148952 crossref_primary_10_3390_nu10060708 crossref_primary_10_1016_j_drudis_2019_12_005 crossref_primary_10_1080_1028415X_2018_1520477 crossref_primary_10_3390_ijms21207471 crossref_primary_10_1002_mds_26069 crossref_primary_10_3892_etm_2019_7943 crossref_primary_10_1002_mds_28004 crossref_primary_10_3390_ijms20081959 |
| Cites_doi | 10.1212/WNL.37.7.1253 10.1007/BF00687767 10.1523/JNEUROSCI.20-16-06309.2000 10.1016/j.jchromb.2006.03.046 10.1179/096805105X46565 10.1152/ajpgi.00041.2008 10.4049/jimmunol.1000458 10.1002/jnr.22036 10.1136/gut.2008.162503 10.1371/journal.pone.0012728 10.1097/MPG.0b013e3181aa3aa9 10.1073/pnas.0509567103 10.1196/annals.1332.007 10.1016/0016-5085(84)90079-9 10.1371/journal.ppat.1001052 10.1074/jbc.270.18.10482 10.1093/hmg/ddm159 10.1136/jnnp.2009.198689 10.1159/000113469 10.1046/j.1440-1746.2003.03032.x 10.1016/j.neulet.2010.01.033 10.1016/S1570-0232(02)00787-0 10.1126/scitranslmed.3000322 10.1128/IAI.69.11.6942-6950.2001 10.1016/S1353-8020(09)70814-4 10.1038/labinvest.3700600 10.1002/glia.20467 10.1038/mi.2010.5 10.1136/oem.60.5.378 10.1111/j.1365-2982.2009.01346.x 10.1016/j.jneuroim.2008.09.017 10.1016/S0140-6736(09)60492-X 10.1126/science.1124234 10.1007/BF00294234 10.1007/s00702-002-0808-2 10.1038/sj.bjp.0707167 10.1136/jnnp.55.3.181 10.1016/S1474-4422(09)70062-6 10.1136/pgmj.72.845.164 10.1212/01.wnl.0000312279.49272.9f 10.1111/j.1460-9568.2009.06873.x 10.1016/j.brainres.2009.02.022 10.1016/j.expneurol.2009.04.023 10.1212/01.wnl.0000247740.47667.03 10.1016/j.neuroscience.2008.02.074 10.1111/j.1365-2990.2007.00874.x |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2011 Public Library of Science 2011 Forsyth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Forsyth et al. 2011 |
| Copyright_xml | – notice: COPYRIGHT 2011 Public Library of Science – notice: 2011 Forsyth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Forsyth et al. 2011 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0028032 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing and Allied Health Journals - PSU access expires 11/30/25. Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest - Health and Medical ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine Biology |
| DocumentTitleAlternate | Leaky Gut, Endotoxin, and Synuclein in Parkinson's |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1311365546 oai_doaj_org_article_8ca2c8dad6624dddb1a6f791ddea07aa PMC3228722 2900375761 A476861290 22145021 10_1371_journal_pone_0028032 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | United States--US Illinois Chicago Illinois |
| GeographicLocations_xml | – name: Illinois – name: United States--US – name: Chicago Illinois |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. BBORY CGR CUY CVF ECM EIF NPM PV9 RZL PMFND 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS RC3 7X8 5PM PUEGO AAPBV ABPTK ESTFP |
| ID | FETCH-LOGICAL-c691t-e19c4b8479bffd00beb299e039e397688dfddf98a9d7f5e2916a4a2bbd7f34b23 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Sun Nov 05 00:20:47 EDT 2023 Wed Aug 27 00:51:37 EDT 2025 Thu Aug 21 13:53:39 EDT 2025 Fri Jul 11 15:20:28 EDT 2025 Fri Jul 25 10:24:43 EDT 2025 Tue Jun 17 21:07:27 EDT 2025 Tue Jun 10 20:16:28 EDT 2025 Fri Jun 27 04:54:55 EDT 2025 Fri Jun 27 03:38:19 EDT 2025 Thu May 22 21:19:51 EDT 2025 Wed Feb 19 01:49:16 EST 2025 Thu Apr 24 22:53:46 EDT 2025 Tue Jul 01 01:20:29 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c691t-e19c4b8479bffd00beb299e039e397688dfddf98a9d7f5e2916a4a2bbd7f34b23 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: AK JK MS. Performed the experiments: CF MS JJ HD JE. Analyzed the data: AK JK KS RV CF MS JE HD. Contributed reagents/materials/analysis tools: AK JK KS RV CF MS JE HD JJ. Wrote the paper: CF AK JK KS RV. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0028032 |
| PMID | 22145021 |
| PQID | 1311365546 |
| PQPubID | 1436336 |
| PageCount | e28032 |
| ParticipantIDs | plos_journals_1311365546 doaj_primary_oai_doaj_org_article_8ca2c8dad6624dddb1a6f791ddea07aa pubmedcentral_primary_oai_pubmedcentral_nih_gov_3228722 proquest_miscellaneous_909288054 proquest_journals_1311365546 gale_infotracmisc_A476861290 gale_infotracacademiconefile_A476861290 gale_incontextgauss_ISR_A476861290 gale_incontextgauss_IOV_A476861290 gale_healthsolutions_A476861290 pubmed_primary_22145021 crossref_primary_10_1371_journal_pone_0028032 crossref_citationtrail_10_1371_journal_pone_0028032 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2011-12-01 |
| PublicationDateYYYYMMDD | 2011-12-01 |
| PublicationDate_xml | – month: 12 year: 2011 text: 2011-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2011 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | JD Estes (ref51) 2010; 6 KM Shannon (ref29) 2011 CW Shults (ref4) 2006; 103 K Wakabayashi (ref23) 1988; 76 C Cirillo (ref41) 2009; 21 RJ Phillips (ref28) 2008; 153 E Emanuele (ref45) 2010; 471 HM Gao (ref40) 2011 PJ Turnbaugh (ref10) 2009; 1 A Farhadi (ref49) 2006; 836 LJ John (ref12) 2011 T Gutsmann (ref16) 2001; 69 AJ Lees (ref1) 2009; 373 SJ Qualman (ref22) 1984; 87 RM Minter (ref18) 2009; 296 TC Savidge (ref8) 2007; 87 AJ Hughes (ref47) 1992; 55 WJ Kupsky (ref21) 1987; 37 A Farhadi (ref13) 2003; 18 RL Kitchens (ref37) 2005; 11 M Maes (ref44) 2008; 29 H Braak (ref14) 2003; 110 Y Ouchi (ref31) 2009; 15 ME McOmber (ref48) 2010; 50 EC Hirsch (ref30) 2009; 8 JG Greene (ref20) 2009; 218 K Wakabayashi (ref25) 1997; 38 T Lebouvier (ref27) 2010; 5 K Shannon (ref19) 2011 WG Kim (ref39) 2000; 20 KN Davies (ref46) 1996; 72 S Menard (ref11) 2010; 3 T Lebouvier (ref26) 2008; 57 S Wang (ref35) 2009; 1265 B Thomas (ref6) 2007; 16 Spec No. 2 K Wakabayashi (ref24) 1990; 79 PS Whitton (ref36) 2007; 150 S Keck (ref38) 2011; 186 R Zhang (ref43) 2009; 206 P Hobson (ref3) 2010; 81 H Braak (ref5) 2008; 70 A Farhadi (ref50) 2003; 784 T Lebouvier (ref7) 2009; 30 L Qin (ref34) 2007; 55 CH Hawkes (ref15) 2007; 33 ER Dorsey (ref2) 2007; 68 PL McGeer (ref32) 2004; 1035 PS Tobias (ref17) 1995; 270 M Murakami (ref42) 2009; 87 I Niehaus (ref33) 2003; 60 SR Gill (ref9) 2006; 312 12721813 - J Neural Transm (Vienna). 2003 May;110(5):517-36 19524782 - Lancet. 2009 Jun 13;373(9680):2055-66 15681803 - Ann N Y Acad Sci. 2004 Dec;1035:104-16 19236855 - Brain Res. 2009 Apr 10;1265:196-204 18948440 - Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G45-54 17911161 - Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R183-94 17339843 - Br J Pharmacol. 2007 Apr;150(8):963-76 16176659 - J Endotoxin Res. 2005;11(4):225-9 17961138 - Neuropathol Appl Neurobiol. 2007 Dec;33(6):599-614 17082464 - Neurology. 2007 Jan 30;68(5):384-6 19235895 - J Neurosci Res. 2009 Jul;87(9):2095-104 12504193 - J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 25;784(1):145-54 2850698 - Acta Neuropathol. 1988;76(3):217-221 6088351 - Gastroenterology. 1984 Oct;87(4):848-56 19013651 - J Neuroimmunol. 2009 Jan 3;206(1-2):121-4 16449387 - Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1661-8 18474848 - Neurology. 2008 May 13;70(20):1916-25 17203472 - Glia. 2007 Apr 1;55(5):453-62 20856865 - PLoS One. 2010;5(9):e12728 19409896 - Exp Neurol. 2009 Jul;218(1):154-61 20571039 - J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1093-8 20082990 - Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S200-4 19296921 - Lancet Neurol. 2009 Apr;8(4):382-97 20368178 - Sci Transl Med. 2009 Nov 11;1(6):6ra14 20404811 - Mucosal Immunol. 2010 May;3(3):247-59 19022934 - Gut. 2008 Dec;57(12):1741-3 11598069 - Infect Immun. 2001 Nov;69(11):6942-50 9387796 - Eur Neurol. 1997;38 Suppl 2:2-7 19712093 - Eur J Neurosci. 2009 Sep;30(5):735-41 19558426 - Neurogastroenterol Motil. 2009 Nov;21(11):1209-e112 12702039 - J Gastroenterol Hepatol. 2003 May;18(5):479-97 10934283 - J Neurosci. 2000 Aug 15;20(16):6309-16 18407422 - Neuroscience. 2008 May 15;153(3):733-50 20081547 - J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):269-75 21441453 - J Immunol. 2011 May 1;186(9):5478-88 16621740 - J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19;836(1-2):63-8 18283240 - Neuro Endocrinol Lett. 2008 Feb;29(1):117-24 21294654 - Antioxid Redox Signal. 2011 Sep 1;15(5):1255-70 8731708 - Postgrad Med J. 1996 Mar;72(845):164-7 21766334 - Mov Disord. 2012 May;27(6):709-15 20097267 - Neurosci Lett. 2010 Mar 8;471(3):162-5 1972853 - Acta Neuropathol. 1990;79(6):581-3 17607301 - Lab Invest. 2007 Aug;87(8):731-6 20808901 - PLoS Pathog. 2010;6(8):e1001052 1564476 - J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4 3037441 - Neurology. 1987 Jul;37(7):1253-5 12709528 - Occup Environ Med. 2003 May;60(5):378 7537731 - J Biol Chem. 1995 May 5;270(18):10482-8 21245015 - Environ Health Perspect. 2011 Jun;119(6):807-14 16741115 - Science. 2006 Jun 2;312(5778):1355-9 |
| References_xml | – volume: 37 start-page: 1253 year: 1987 ident: ref21 article-title: Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells. publication-title: Neurology doi: 10.1212/WNL.37.7.1253 – volume: 76 start-page: 217 year: 1988 ident: ref23 article-title: Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses. publication-title: Acta Neuropathol doi: 10.1007/BF00687767 – year: 2011 ident: ref40 article-title: Neuroinflammation and alpha-Synuclein Dysfunction Potentiate Each Other Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson's Disease. publication-title: Environ Health Perspect – year: 2011 ident: ref19 article-title: Alpha-synuclein in Colonic Submucosa in Early Untreated Parkinson Disease. publication-title: Movement Disorders – volume: 20 start-page: 6309 year: 2000 ident: ref39 article-title: Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.20-16-06309.2000 – volume: 836 start-page: 63 year: 2006 ident: ref49 article-title: Resolution of common dietary sugars from probe sugars for test of intestinal permeability using capillary column gas chromatography. publication-title: J Chromatogr B Analyt Technol Biomed Life Sci doi: 10.1016/j.jchromb.2006.03.046 – volume: 11 start-page: 225 year: 2005 ident: ref37 article-title: Modulatory effects of sCD14 and LBP on LPS-host cell interactions. publication-title: J Endotoxin Res doi: 10.1179/096805105X46565 – volume: 296 start-page: G45 year: 2009 ident: ref18 article-title: LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction. publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00041.2008 – volume: 186 start-page: 5478 year: 2011 ident: ref38 article-title: Absence of TRIF Signaling in Lipopolysaccharide-Stimulated Murine Mast Cells. publication-title: J Immunol doi: 10.4049/jimmunol.1000458 – volume: 87 start-page: 2095 year: 2009 ident: ref42 article-title: Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin-1beta from enteric glial cells. publication-title: J Neurosci Res doi: 10.1002/jnr.22036 – volume: 57 start-page: 1741 year: 2008 ident: ref26 article-title: Pathological lesions in colonic biopsies during Parkinson's disease. publication-title: Gut doi: 10.1136/gut.2008.162503 – volume: 5 start-page: e12728 year: 2010 ident: ref27 article-title: Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms. publication-title: PLoS One doi: 10.1371/journal.pone.0012728 – volume: 50 start-page: 269 year: 2010 ident: ref48 article-title: Effects of timing, sex, and age on site-specific gastrointestinal permeability testing in children and adults. publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/MPG.0b013e3181aa3aa9 – volume: 103 start-page: 1661 year: 2006 ident: ref4 article-title: Lewy bodies. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0509567103 – volume: 1035 start-page: 104 year: 2004 ident: ref32 article-title: Inflammation and the degenerative diseases of aging. publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1332.007 – volume: 87 start-page: 848 year: 1984 ident: ref22 article-title: Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease. publication-title: Gastroenterology doi: 10.1016/0016-5085(84)90079-9 – volume: 6 year: 2010 ident: ref51 article-title: Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1001052 – volume: 270 start-page: 10482 year: 1995 ident: ref17 article-title: Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. publication-title: J Biol Chem doi: 10.1074/jbc.270.18.10482 – volume: 16 Spec No. 2 start-page: R183 year: 2007 ident: ref6 article-title: Parkinson's disease. publication-title: Hum Mol Genet doi: 10.1093/hmg/ddm159 – volume: 81 start-page: 1093 year: 2010 ident: ref3 article-title: The estimated life expectancy in a community cohort of Parkinson's disease patients with and without dementia, compared with the UK population. publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2009.198689 – volume: 38 start-page: 2 year: 1997 ident: ref25 article-title: Neuropathology of autonomic nervous system in Parkinson's disease. publication-title: Eur Neurol doi: 10.1159/000113469 – volume: 18 start-page: 479 year: 2003 ident: ref13 article-title: Intestinal barrier: an interface between health and disease. publication-title: J Gastroenterol Hepatol doi: 10.1046/j.1440-1746.2003.03032.x – volume: 471 start-page: 162 year: 2010 ident: ref45 article-title: Low-grade endotoxemia in patients with severe autism. publication-title: Neurosci Lett doi: 10.1016/j.neulet.2010.01.033 – volume: 784 start-page: 145 year: 2003 ident: ref50 article-title: Gas chromatographic method for detection of urinary sucralose: application to the assessment of intestinal permeability. publication-title: J Chromatogr B Analyt Technol Biomed Life Sci doi: 10.1016/S1570-0232(02)00787-0 – volume: 1 start-page: 6ra14 year: 2009 ident: ref10 article-title: The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3000322 – year: 2011 ident: ref12 article-title: Epithelial barriers in intestinal inflammation. publication-title: Antioxid Redox Signal – volume: 69 start-page: 6942 year: 2001 ident: ref16 article-title: Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells. publication-title: Infect Immun doi: 10.1128/IAI.69.11.6942-6950.2001 – volume: 15 start-page: S200 year: 2009 ident: ref31 article-title: Neuroinflammation in the living brain of Parkinson's disease. publication-title: Parkinsonism Relat Disord doi: 10.1016/S1353-8020(09)70814-4 – volume: 87 start-page: 731 year: 2007 ident: ref8 article-title: Starring roles for astroglia in barrier pathologies of gut and brain. publication-title: Lab Invest doi: 10.1038/labinvest.3700600 – volume: 55 start-page: 453 year: 2007 ident: ref34 article-title: Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. publication-title: Glia doi: 10.1002/glia.20467 – volume: 3 start-page: 247 year: 2010 ident: ref11 article-title: Multiple facets of intestinal permeability and epithelial handling of dietary antigens. publication-title: Mucosal Immunol doi: 10.1038/mi.2010.5 – volume: 60 start-page: 378 year: 2003 ident: ref33 article-title: Endotoxin: is it an environmental factor in the cause of Parkinson's disease? publication-title: Occup Environ Med doi: 10.1136/oem.60.5.378 – volume: 21 start-page: 1209-e1112 year: 2009 ident: ref41 article-title: Increased mucosal nitric oxide production in ulcerative colitis is mediated in part by the enteroglial-derived S100B protein. publication-title: Neurogastroenterol Motil doi: 10.1111/j.1365-2982.2009.01346.x – volume: 206 start-page: 121 year: 2009 ident: ref43 article-title: Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS). publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2008.09.017 – volume: 373 start-page: 2055 year: 2009 ident: ref1 article-title: Parkinson's disease. publication-title: Lancet doi: 10.1016/S0140-6736(09)60492-X – volume: 312 start-page: 1355 year: 2006 ident: ref9 article-title: Metagenomic analysis of the human distal gut microbiome. publication-title: Science doi: 10.1126/science.1124234 – volume: 79 start-page: 581 year: 1990 ident: ref24 article-title: Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. publication-title: Acta Neuropathol doi: 10.1007/BF00294234 – volume: 110 start-page: 517 year: 2003 ident: ref14 article-title: Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. publication-title: J Neural Transm doi: 10.1007/s00702-002-0808-2 – volume: 150 start-page: 963 year: 2007 ident: ref36 article-title: Inflammation as a causative factor in the aetiology of Parkinson's disease. publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0707167 – volume: 55 start-page: 181 year: 1992 ident: ref47 article-title: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.55.3.181 – volume: 8 start-page: 382 year: 2009 ident: ref30 article-title: Neuroinflammation in Parkinson's disease: a target for neuroprotection? publication-title: Lancet Neurol doi: 10.1016/S1474-4422(09)70062-6 – volume: 29 start-page: 117 year: 2008 ident: ref44 article-title: The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. publication-title: Neuro Endocrinol Lett – volume: 72 start-page: 164 year: 1996 ident: ref46 article-title: Intestinal permeability and orocaecal transit time in elderly patients with Parkinson's disease. publication-title: Postgrad Med J doi: 10.1136/pgmj.72.845.164 – volume: 70 start-page: 1916 year: 2008 ident: ref5 article-title: Invited Article: Nervous system pathology in sporadic Parkinson disease. publication-title: Neurology doi: 10.1212/01.wnl.0000312279.49272.9f – volume: 30 start-page: 735 year: 2009 ident: ref7 article-title: The second brain and Parkinson's disease. publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2009.06873.x – volume: 1265 start-page: 196 year: 2009 ident: ref35 article-title: Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. publication-title: Brain Res doi: 10.1016/j.brainres.2009.02.022 – volume: 218 start-page: 154 year: 2009 ident: ref20 article-title: Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease. publication-title: Exp Neurol doi: 10.1016/j.expneurol.2009.04.023 – year: 2011 ident: ref29 article-title: Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. publication-title: Mov Disord – volume: 68 start-page: 384 year: 2007 ident: ref2 article-title: Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. publication-title: Neurology doi: 10.1212/01.wnl.0000247740.47667.03 – volume: 153 start-page: 733 year: 2008 ident: ref28 article-title: Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease? publication-title: Neuroscience doi: 10.1016/j.neuroscience.2008.02.074 – volume: 33 start-page: 599 year: 2007 ident: ref15 article-title: Parkinson's disease: a dual-hit hypothesis. publication-title: Neuropathol Appl Neurobiol doi: 10.1111/j.1365-2990.2007.00874.x – reference: 12504193 - J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 25;784(1):145-54 – reference: 18283240 - Neuro Endocrinol Lett. 2008 Feb;29(1):117-24 – reference: 16449387 - Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1661-8 – reference: 18474848 - Neurology. 2008 May 13;70(20):1916-25 – reference: 19296921 - Lancet Neurol. 2009 Apr;8(4):382-97 – reference: 10934283 - J Neurosci. 2000 Aug 15;20(16):6309-16 – reference: 19712093 - Eur J Neurosci. 2009 Sep;30(5):735-41 – reference: 20856865 - PLoS One. 2010;5(9):e12728 – reference: 15681803 - Ann N Y Acad Sci. 2004 Dec;1035:104-16 – reference: 3037441 - Neurology. 1987 Jul;37(7):1253-5 – reference: 18407422 - Neuroscience. 2008 May 15;153(3):733-50 – reference: 16176659 - J Endotoxin Res. 2005;11(4):225-9 – reference: 17607301 - Lab Invest. 2007 Aug;87(8):731-6 – reference: 20404811 - Mucosal Immunol. 2010 May;3(3):247-59 – reference: 2850698 - Acta Neuropathol. 1988;76(3):217-221 – reference: 1564476 - J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4 – reference: 19235895 - J Neurosci Res. 2009 Jul;87(9):2095-104 – reference: 17911161 - Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R183-94 – reference: 12702039 - J Gastroenterol Hepatol. 2003 May;18(5):479-97 – reference: 21441453 - J Immunol. 2011 May 1;186(9):5478-88 – reference: 20082990 - Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S200-4 – reference: 6088351 - Gastroenterology. 1984 Oct;87(4):848-56 – reference: 19013651 - J Neuroimmunol. 2009 Jan 3;206(1-2):121-4 – reference: 21245015 - Environ Health Perspect. 2011 Jun;119(6):807-14 – reference: 17961138 - Neuropathol Appl Neurobiol. 2007 Dec;33(6):599-614 – reference: 19022934 - Gut. 2008 Dec;57(12):1741-3 – reference: 20081547 - J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):269-75 – reference: 16621740 - J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19;836(1-2):63-8 – reference: 21294654 - Antioxid Redox Signal. 2011 Sep 1;15(5):1255-70 – reference: 12709528 - Occup Environ Med. 2003 May;60(5):378 – reference: 19524782 - Lancet. 2009 Jun 13;373(9680):2055-66 – reference: 20808901 - PLoS Pathog. 2010;6(8):e1001052 – reference: 21766334 - Mov Disord. 2012 May;27(6):709-15 – reference: 7537731 - J Biol Chem. 1995 May 5;270(18):10482-8 – reference: 20571039 - J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1093-8 – reference: 17082464 - Neurology. 2007 Jan 30;68(5):384-6 – reference: 1972853 - Acta Neuropathol. 1990;79(6):581-3 – reference: 20368178 - Sci Transl Med. 2009 Nov 11;1(6):6ra14 – reference: 11598069 - Infect Immun. 2001 Nov;69(11):6942-50 – reference: 19558426 - Neurogastroenterol Motil. 2009 Nov;21(11):1209-e112 – reference: 16741115 - Science. 2006 Jun 2;312(5778):1355-9 – reference: 12721813 - J Neural Transm (Vienna). 2003 May;110(5):517-36 – reference: 20097267 - Neurosci Lett. 2010 Mar 8;471(3):162-5 – reference: 17203472 - Glia. 2007 Apr 1;55(5):453-62 – reference: 8731708 - Postgrad Med J. 1996 Mar;72(845):164-7 – reference: 19236855 - Brain Res. 2009 Apr 10;1265:196-204 – reference: 9387796 - Eur Neurol. 1997;38 Suppl 2:2-7 – reference: 17339843 - Br J Pharmacol. 2007 Apr;150(8):963-76 – reference: 18948440 - Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G45-54 – reference: 19409896 - Exp Neurol. 2009 Jul;218(1):154-61 |
| SSID | ssj0053866 |
| Score | 2.574951 |
| Snippet | Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e28032 |
| SubjectTerms | Acute-Phase Proteins - metabolism Aged Aging alpha-Synuclein - metabolism Amyotrophic lateral sclerosis Autism Bacteria Biology Biomarkers - metabolism Carrier Proteins - metabolism Chromatography Correlation E coli Endotoxins Endotoxins - pharmacology Enteric nervous system Escherichia coli - pathogenicity Escherichia coli Infections - metabolism Escherichia coli Infections - microbiology Exposure Female Gastroenterology Gram-negative bacteria Humans Immunoenzyme Techniques Immunohistochemistry Inflammation Internal medicine Intestine Intestines - metabolism Intestines - microbiology Intestines - pathology Lewy bodies Lipopolysaccharides Male Markers Medicine Membrane Glycoproteins - metabolism Mental depression Middle Aged Movement disorders Mucosa Nerves Neurodegenerative diseases Neurons Neurons - metabolism Neurons - microbiology Neurons - pathology Nitrotyrosine Oxidative Stress Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Pathogenesis Pathology Permeability Protein binding Rodents Small intestine Staining Sucrose - analogs & derivatives Sucrose - metabolism Synuclein Toxins Translocation Tyrosine - analogs & derivatives Tyrosine - metabolism |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggyquBAhZCKhxCs47jxMeCqAoSIAFFvVl-pV1pN4maXan9IfxfZhxv1KBK5cBlpbUnq-y8bc98JuS1LqwveO5Tx-oshXjtUs3hI8tt5o10hQjXAX35Ko5P-OfT4vTaVV9YEzbAAw-MO6isZrZy2gnBuHPOzLWoSzkHs9RZqUNqBDFvu5gafDBYsRCxUS4v5wdRLu-6tvGhdDLL2SQQBbz-0SvPumXb35Ry_l05eS0UHd0n92IOSQ-Hd98hd3zzgOxEK-3pmwgl_fYh-Q3mj1Xn3lHEhQBzxgc78MZ-wOe-ohav51hixklxT5b2i7NVu3B0haXsmoZe3LS_ahD3eNHQ0G4F4Y7qxlHfwJq2vYRhf9m1uNdIV1juc9FTHEPsZIpt1aHDbL-n8TToETk5-vjzw3EaL2JIrZDzdern0nIDcUyaunZZZmA5LqXPcukxnakqVztXy0pLV9aFZ5Byaq6ZMfA154blj8msAdbvElp5AV5DC81Ky0ubGy9goAJ9EUYYxhKSb6WibEQpx8syliocvZWwWhmYrFCWKsoyIen4VDegdNxC_x4FPtIixnYYAM1TUfPUbZqXkJeoLmpoWB09hTrkwBKB-3sJeRUoEGejwUKeM73pe_Xp269_IPrxfUK0H4nqFthhdWyegP-E-F0Tyr0JJXgLO5neReXecqVXCLeUC6xVhCe3Cn_zNB2n8UexOK_x7aZXMpMMwkDBE_JkMI-RsQyB8CGNTEg5MZwJ56czzeI8oJxDpKlKxp7-D1E9I3fDWUAoQ9ojs_XFxj-HZHJtXgS_8QdY0Xq3 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegSIgXxMbHAgMshDR4CEucxImf0BgdA6mAKEN7i_yVUqkkZWml7Q_h_-XOcQNBE_BSqfYlan2-D5_vfkfIU5lpm6WJDQ2rohDstQllCh9RoiOrhMm4awc0ec-PT9J3p9mpD7i1Pq1yoxOdojaNxhj5PsLCJBxzql4uv4fYNQpvV30LjavkWgyWBlO6iqM3G00Mssy5L5dL8njfc-fFsqmtS6CMEjYwRw61v9fNo-WiaS9zPP_Mn_zNIB3dIje9J0kPOtZvkSu23ibXJ_6ufJtsebFt6TOPLf38NvkB-gDT0K2hGAsE-cZ3fAT1bDvA7gt6iP06FuiCUgzS0ul89q2ZGzrB3HZJXXFuOL2oEQh5XtPpqusxQWVt6LiGQ25zDsPj82WDwUeKxUDgYlIcQzBlinXWruRsr6Wvu-uhO-TkaPz58Dj0nRlCzUW8Cm0sdKrAsAlVVSaKFJzPhbBRIiz6N0VhKmMqUUhh8iqzDHxQmUqmFHxNUsWSu2RUAxd2CC0sBzUiuWS5TnOdKMthoIANxBVXjAUk2TCo1B62HLtnLEp3F5fD8aVb7xLZWnq2BiTsn1p2sB3_oH-FvO9pEXTbDTRns9LLcFloyXRhpOGcpcYYFUte5SIGCyGjXMqAPMadU3YVrL3qKA9SWBKOAb-APHEUCLxRY2bPTK7btnz74ct_EE0_DYj2PFHVwHJo6asp4D8hoNeAcndACepDD6Z3cJ9vVqUtfwkaPLnZ-5dP034aX4rZerVt1m0pIsHALmRpQO51ktIvLENkfPArA5IPZGiw8sOZev7VwZ6D6Slyxu7__Vc9IDdc2N9lHO2S0epsbR-C37hSj5xy-An15HGe priority: 102 providerName: ProQuest |
| Title | Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22145021 https://www.proquest.com/docview/1311365546 https://www.proquest.com/docview/909288054 https://pubmed.ncbi.nlm.nih.gov/PMC3228722 https://doaj.org/article/8ca2c8dad6624dddb1a6f791ddea07aa http://dx.doi.org/10.1371/journal.pone.0028032 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdG98ILYnwtMIqFkAYPmRIncZIHhLbSMpA6ppWivkV27JRKJSlNK7Uv_Bf8v9w5aURQEXuxVPscqWffh-273xHySgSpDnxP24pljg32WtnCh8bxUkfLWAXclAMaXvHLsf9pEkwOyK5ma83Acu_RDutJjZfzs82P7TsQ-LemakPo7iadLYpcm8BIxwOlfAi2KcSaBkO_eVcA6Tavl-i12Jw5Xp1M96-vtIyVwfRvNHdnMS_KfW7p39GVf5irwX1yr_Yz6Xm1MY7Igc4fkKNakkv6uoabfvOQ_AIVgZHpWlG8HgSRx4nXoLF1heG9pT0s4TFHr5TivS0dzabfi5miQwx3F9Tk69qjbY7YyLOcjlZV2QkqckX7OZx7iw109zeLAu8jKeYHgddJsQ_xlSmmXpsstNOSvq9ejB6R8aD_pXdp18Ua7JTH7srWbpz6EmxdLLNMOY6EI3sca8eLNbo8UaQypbI4ErEKs0AzcEuFL5iU8NPzJfMek04OrD8mNNIcNIvggoWpH6ae1Bw6IthTXHLJmEW83aokaY1kjgU15ol5ngvhRFMxOcG1TOq1tIjdzFpUSB7_ob_ABW9oEYfbdBTLaVKLdRKlgqWREopz5iulpCt4FsYuGA3hhEJY5AVul6RKam20SXLuA0s43gFa5KWhQCyOHIN9pmJdlsnHz19vQTS6aRGd1kRZAexIRZ1gAf8JMb5alCctStAoaWv4GDf3jitlgpBMHsd4Rpi52_D7h2kzjB_FAL5cF-syiZ2YgakIfIs8qcSjYSxDsHxwNS0StgSnxfn2SD77ZpDQwRpFIWNPb8PDZ-SueQ8woUgnpLNarvVzcChXskvuhJMQ2qjnYjv40CWHF_2r65uuuaLpGh2C7c_-b0Iqfnk |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELemIQEviI0_CwxmIdDgIVvqJE7ygNDYWlq2DkQ3tLfgxE6pVJKytGL9IHwNPiN3jhMImoCXvVSqfYnau_Pvzvb9IeSp8FPle66yJcscG-y1tIUHH46bOiqJpM91O6DhMe-fem_P_LMV8qPOhcGwyhoTNVDLIsUz8l0sC-NyjKl6NftqY9covF2tW2hUanGolt9gy1a-HByAfJ8x1uue7Pdt01XATnnUmduqE6VeAqAcJVkmHSeBvWUUKceNFNrmMJSZlFkUikgGma8Y-E_CEyxJ4KvrJVjoACD_mucCNWam997UyA_YwblJz3ODzq7Rhp1ZkSsdsOm4rGX-dJeAxhaszqZFeZmj-2e85m8GsHeb3DKeK92rVG2NrKh8nVwfmrv5dbJmYKKkz00t6xd3yHfAHwx7V5Li2SPgCb7jPZgDVRUIX9J97A8yRZeX4qEwHU3GX4qJpEOMpRdUJwPbo2WOhZcnOR3Nq54WVOSSdnPYVBcXMNy9mBV42Ekx-QhcWopjWLyZYl63TnHbLulBdR11l5xeiczukdUcpLBBaKg4wJbgggWpF6RuojgMhKCwPOEJYxZxawHFqSmTjt06prG--wtgu1TxO0axxkasFrGbp2ZVmZB_0L9G2Te0WORbDxTn49hgRhymgqWhFJJz5kkpk47gWRB1wCIJJxDCIluoOXGVMdtAVbznAUs4HjBa5ImmwEIfOUYSjcWiLOPBu4__QTT60CLaNkRZAexIhcnegP-EBcRalJstSoCrtDW9gXpec6WMfy1seLLW_cunaTONL8XowFwVizKOnIiBHfI9i9yvVkrDWIaV-MGPtUjQWkMtzrdn8slnXWYdTF0YMPbg779qi9zonwyP4qPB8eFDclNfOehop02yOj9fqEfgs86TxxooKPl01cj0E97msBw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemIk28IDY-FhjMQqDBQ2jqJE7ygNDoh1ZGx0TZtLfgxE6pVJKytGL9Q_hn-Ou4c9xA0AS87KVS7UvU3p1_d7bvg5Cnwk-V77nKlixzbLDX0hYefDhu6qgkkj7X7YBGx_zw1Ht77p9vkB_rXBgMq1xjogZqWaR4Rt7GsjAux5iqdmbCIk56g9fzrzZ2kMKb1nU7jUpFjtTqG2zfylfDHsj6GWOD_sfuoW06DNgpjzoLW3Wi1EsAoKMky6TjJLDPjCLluJFCOx2GMpMyi0IRySDzFQNfSniCJQl8db0Eix4A_N8I3CDENRZ26_ASwBHOTaqeG3TaRjNezotc6eBNx2UNU6g7BtR2oTWfFeVVTu-fsZu_GcPBbXLLeLH0oFK7LbKh8m2yOTL39Ntky0BGSZ-butYv7pDvgEUYAq8kxXNIwBZ8xwmYBlUVC1_RLvYKmaH7S_GAmI6nky_FVNIRxtULqhOD7fEqxyLM05yOF1V_CypySfs5bLCLSxjuX84LPPikmIgE7i3FMSzkTDHHW6e77Ze0V11N3SWn1yKze6SVgxR2CA0VBwgTXLAg9YLUTRSHgRCUlyc8Ycwi7lpAcWpKpmPnjlms7wED2DpV_I5RrLERq0Xs-ql5VTLkH_RvUPY1LRb81gPFxSQ2-BGHqWBpKIXknHlSyqQjeBZEHbBOwgmEsMgeak5cZc_WsBUfeMASjoeNFnmiKbDoR47LZyKWZRkP35_9B9H4Q4No3xBlBbAjFSaTA_4TFhNrUO42KAG60sb0Dur5mitl_GuRw5Nr3b96mtbT-FKMFMxVsSzjyIkY2CTfs8j9aqXUjGVYlR98WosEjTXU4HxzJp9-1iXXweyFAWMP_v6r9sgmYFL8bnh89JDc1LcPOvBpl7QWF0v1CNzXRfJY4wQln64bmH4CX1G0HQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+Intestinal+Permeability+Correlates+with+Sigmoid+Mucosa+alpha-Synuclein+Staining+and+Endotoxin+Exposure+Markers+in+Early+Parkinson%27s+Disease&rft.jtitle=PloS+one&rft.au=Forsyth%2C+Christopher+B&rft.au=Shannon%2C+Kathleen+M&rft.au=Kordower%2C+Jeffrey+H&rft.au=Voigt%2C+Robin+M&rft.date=2011-12-01&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=6&rft.issue=12&rft.spage=e28032&rft_id=info:doi/10.1371%2Fjournal.pone.0028032&rft.externalDBID=IOV&rft.externalDocID=A476861290 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |