Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

• Published in: ENDOCRINE JOURNAL Vol. 67; no. 2; pp. 153 - 160
• Main Authors: Irie, Junichiro, Inagaki, Emi, Fujita, Masataka, Nakaya, Hideaki, Mitsuishi, Masanori, Yamaguchi, Shintaro, Yamashita, Kazuya, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Okano, Hideyuki, Nabeshima, Yo-ichi, Imai, Shin-ichiro, Yasui, Masato, Tsubota, Kazuo, Itoh, Hiroshi
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 01.01.2020; Japan Science and Technology Agency
• Subjects: Adenine; Administration, Oral; Adult; Aging; Animal models; Bilirubin; Bilirubin - blood; Blood Glucose - drug effects; Blood Glucose - metabolism; Blood pressure; Blood Pressure - drug effects; Body temperature; Body Temperature - drug effects; Chlorides - blood; Chromatography, Liquid; Creatinine; Creatinine - blood; Diagnostic Techniques, Ophthalmological; Dose-Response Relationship, Drug; Electrocardiography; Healthy Volunteers; Heart rate; Heart Rate - drug effects; Humans; Intraocular Pressure - drug effects; Japan; Male; Metabolites; Middle Aged; N-methyl-2-pyridone-5-carboxamide; N-methyl-4-pyridone-5-carboxamide; NAD; Niacinamide - analogs & derivatives; Niacinamide - metabolism; Nicotinamide; Nicotinamide mononucleotide; Nicotinamide Mononucleotide - analogs & derivatives; Nicotinamide Mononucleotide - metabolism; Nicotinamide Mononucleotide - pharmacology; Oral administration; Oxygen - metabolism; Pharmacokinetics; Pyridones - metabolism; Quality control; Sleep; Sleep - drug effects; Tandem Mass Spectrometry; Visual Acuity; Japan; N-methyl-2-pyridone-5-carboxamide; N-methyl-4-pyridone-5-carboxamide; Pharmacokinetics; Nicotinamide mononucleotide

Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to...