Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men - Irie, Junichiro; Inagaki, Emi; Fujita, Masataka; Nakaya, Hideaki; Mitsuishi, Masanori; Yamaguchi, Shintaro; Yamashita, Kazuya; Shigaki, Shuhei; Ono, Takashi; Yukioka, Hideo; Okano, Hideyuki; Nabeshima, Yo-ichi; et al. (ENDOCRINE JOURNAL, 2020)
Keywords: Adenine; Administration, Oral; Adult; Aging; Animal models; Bilirubin; Bilirubin - blood; Blood Glucose - drug effects; Blood Glucose - metabolism; Blood pressure; Blood Pressure - drug effects; Body temperature; Body Temperature - drug effects; Chlorides - blood; Chromatography, Liquid; Creatinine; Creatinine - blood; Diagnostic Techniques, Ophthalmological; Dose-Response Relationship, Drug; Electrocardiography; Healthy Volunteers; Heart rate; Heart Rate - drug effects; Humans; Intraocular Pressure - drug effects; Japan; Male; Metabolites; Middle Aged; N-methyl-2-pyridone-5-carboxamide; N-methyl-4-pyridone-5-carboxamide; NAD; Niacinamide - analogs & derivatives; Niacinamide - metabolism; Nicotinamide; Nicotinamide mononucleotide; Nicotinamide Mononucleotide - analogs & derivatives; Nicotinamide Mononucleotide - metabolism; Nicotinamide Mononucleotide - pharmacology; Oral administration; Oxygen - metabolism; Pharmacokinetics; Pyridones - metabolism; Quality control; Sleep; Sleep - drug effects; Tandem Mass Spectrometry; Visual Acuity; Japan; N-methyl-2-pyridone-5-carboxamide; N-methyl-4-pyridone-5-carboxamide; Pharmacokinetics; Nicotinamide mononucleotide