Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation

• Published in: PloS one Vol. 6; no. 9; p. e24795
• Main Authors: Roney, Kelly E, O'Connor, Brian P, Wen, Haitao, Holl, Eda K, Guthrie, Elizabeth H, Davis, Beckley K, Jones, Stephen W, Jha, Sushmita, Sharek, Lisa, Garcia-Mata, Rafael, Bear, James E, Ting, Jenny P-Y
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.09.2011; Public Library of Science (PLoS)
• Subjects: Animals; Antigen presenting cells; Bacteria; Biology; Blotting, Western; Bone Marrow Cells - metabolism; cdc42 GTP-Binding Protein - metabolism; Cdc42 protein; Cell activation; Cell adhesion & migration; Cell Movement; Cell surface; Cell Transplantation - methods; Cells, Cultured; Chemotactic factors; Cytokines; Cytokines - metabolism; Cytoskeleton; Dendritic cells; Developmental biology; Drosophila; E coli; Extracellular matrix; Female; Flow Cytometry; G proteins; Guanosine triphosphate; Humans; Immune system; Immunology; Inflammation; Innate immunity; Insects; Kinases; Leukocyte Common Antigens - metabolism; Leukocyte migration; Ligands; Liver - cytology; Liver - embryology; Liver - metabolism; Macrophages; Macrophages - cytology; Macrophages - metabolism; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Morphogenesis; Motility; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nervous system; Phagocytosis; Prostate cancer; Protein Binding; rac1 GTP-Binding Protein - metabolism; Receptors; Signaling; Spleen - cytology; Spleen - metabolism; Wound healing; Yeast; North Carolina; United States > US; Colorado

Plexins are cell surface receptors widely studied in the nervous system, where they mediate migration and morphogenesis though the Rho family of small GTPases. More recently, plexins have been implicated in immune processes including cell-cell interaction, immune activation, migration, and cytokine...