Aberrant Hippocampal Subregion Networks Associated with the Classifications of aMCI Subjects: A Longitudinal Resting-State Study

• Published in: PloS one Vol. 6; no. 12; p. e29288
• Main Authors: Bai, Feng, Xie, Chunming, Watson, David R., Shi, Yongmei, Yuan, Yonggui, Wang, Yi, Yue, Chunxian, Teng, Yuhuan, Wu, Di, Zhang, Zhijun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.12.2011; Public Library of Science (PLoS)
• Subjects: Aberration; Activities of daily living; Advertising executives; Alzheimer's disease; Biology; Biomarkers; Brain; Case-Control Studies; Cerebellum; Classification; Cognitive ability; Converters; Cortex (cingulate); Cortex (frontal); Cortex (subicular); Cortex (temporal); Dementia; Dentate gyrus; Family medical history; Frontal gyrus; Functional magnetic resonance imaging; Hippocampus; Hippocampus - anatomy & histology; Hippocampus - physiology; Humans; Magnetic Resonance Imaging; Medical imaging; Medical schools; Medicine; Memory; Networks; Neurodegenerative diseases; Neurology; Sensitivity; Structure-function relationships; Studies; Subiculum; Temporal lobe; China

Altered hippocampal structure and function is a valuable indicator of possible conversion from amnestic type mild cognitive impairment (aMCI) to Alzheimer's disease (AD). However, little is known about the disrupted functional connectivity of hippocampus subregional networks in aMCI subjects. a...