Genetic Variation at Selected SNPs in the Leptin Gene and Association of Alleles with Markers of Kidney Disease in a Xhosa Population of South Africa

• Published in: PloS one Vol. 5; no. 2; p. e9086
• Main Authors: Okpechi, Ikechi G., Rayner, Brian L., van der Merwe, Lize, Mayosi, Bongani M., Adeyemo, Adebowale, Tiffin, Nicki, Ramesar, Rajkumar
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.02.2010; Public Library of Science (PLoS)
• Subjects: Adult; African Continental Ancestry Group - genetics; Albumin; Albuminuria - urine; Alleles; Analysis; Atherosclerosis; Base Sequence; Biomarkers; Body fat; Body mass index; Cardiovascular disease; Chronic Disease; Chronic kidney failure; Collagen; Creatinine; Creatinine - blood; Creatinine - urine; Diabetes; End-stage renal disease; Epidermal growth factor receptors; Female; Gene Frequency; Genes; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease; Genetic Variation; Genetics; Genetics and Genomics/Complex Traits; Genotype; Genotypes; Glomerular Filtration Rate; Haplotypes; Hospitals; Humans; Hypertension; Hypertension - complications; Infectious diseases; Kidney diseases; Kidney Diseases - complications; Kidney Diseases - ethnology; Kidney Diseases - genetics; Kidneys; Leptin; Leptin - blood; Leptin - genetics; Linkage Disequilibrium; Lymphoma; Male; Markers; Medical research; Medicine; Middle Aged; Nephrology/Chronic Kidney Disease; Nephrology/Hereditary, Genetic, and Development Nephrology; Obesity; Polymorphism, Single Nucleotide; Population; Population genetics; Public health; Renal function; Risk factors; Rodents; Single nucleotide polymorphisms; Single-nucleotide polymorphism; South Africa; Urine; South Africa; United States > US

Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease (ESRD) with as many as 2 million people predicted to need therapy worldwide by 2010. Obesity is a risk factor for CKD and leptin, the obesity hormone, correlates with body fat mass and markers o...