NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease - Cook, Anthony L.; Vitale, Alejandra M.; Ravishankar, Sugandha; Matigian, Nicholas; Sutherland, Greg T.; Shan, Jiangou; Sutharsan, Ratneswary; Perry, Chris; Silburn, Peter A.; Mellick, George D.; Whitelaw, Murray L.; Wells, Christine A.; et al. (PloS one, 2011)
Keywords: 1-Phosphatidylinositol 3-kinase; Ablation; AKT protein; Analysis; Antioxidants; Biology; Case-Control Studies; Cell Line; Cell lines; Defects; Dehydrogenases; Disease control; Drosophila; Enzymes; Etiology; Female; Gene expression; Gene Silencing; Genetic engineering; Glutathione; Glutathione - metabolism; Humans; Hydrogen peroxide; Insects; Isothiocyanates; Kinases; Male; Medical research; Medicine; Metabolic rate; Metabolism; Movement disorders; Mucosa; Neuroblastoma; Neurodegenerative diseases; NF-E2-Related Factor 2 - deficiency; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Olfactory epithelium; Olfactory Mucosa - drug effects; Olfactory Mucosa - metabolism; Olfactory Mucosa - pathology; Oxidative stress; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Parkinsons disease; Pathology; Patients; Physiological aspects; Proteins; Rodents; Salts; Signal transduction; Signal Transduction - drug effects; Signaling; siRNA; Stem cells; Stress response; Tetrazolium Salts - metabolism; Thiazoles - metabolism; Thiocyanates - pharmacology; Transcription factors; Queensland Australia; Australia