Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury

• Published in: PloS one Vol. 7; no. 2; p. e32260
• Main Authors: Lapchak, Peter H, Ioannou, Antonis, Kannan, Lakshmi, Rani, Poonam, Dalle Lucca, Jurandir J, Tsokos, George C
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.02.2012; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Atherosclerosis; B cells; Biology; Blood platelets; Blood Platelets - cytology; Blood Platelets - metabolism; Cardiovascular disease; CD40 antigen; CD40 Antigens - genetics; CD40 Antigens - physiology; CD40 Ligand - genetics; CD40 Ligand - physiology; CD40L protein; Complement System Proteins; Damage; Endotoxins - metabolism; Female; Image Processing, Computer-Assisted; Immunohistochemistry - methods; Inflammation; Inflammatory bowel disease; Injuries; Intestine; Intestines - pathology; Ischemia; Ligands; Lung - pathology; Lung diseases; Lungs; Male; Medical schools; Medicine; Mice; Mice, Inbred C57BL; Models, Biological; Neutrophils; Oxidative stress; Pathogenesis; Platelets; Reperfusion; Reperfusion Injury - metabolism; Rheumatology; Rodents; Stroke; Thromboembolism; Time Factors; Trends; United States > US; Massachusetts

Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors in the process of tissue damage after ischemia reperfusion (I/R) injury. It is currently unknown whether platelets participa...