Broad Antibody Mediated Cross-Neutralization and Preclinical Immunogenicity of New Codon-Optimized HIV-1 Clade CRF02_AG and G Primary Isolates

• Published in: PloS one Vol. 6; no. 8; p. e23233
• Main Authors: Agwale, Simon M., Forbi, Joseph C., Notka, Frank, Wrin, Terri, Wild, Jens, Wagner, Ralf, Wolf, Hans
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.08.2011; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; AIDS Vaccines; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antigens; Binding sites; Biology; Cell Line, Tumor; Codon; Codons; Conserved sequence; Deoxyribonucleic acid; Development and progression; DNA; Enzyme-Linked Immunosorbent Assay; Epidemics; Female; Flow Cytometry; Gene therapy; HIV; HIV Antibodies - biosynthesis; HIV Antibodies - immunology; HIV tests; HIV-1 - classification; HIV-1 - genetics; HIV-1 - immunology; Human immunodeficiency virus; Humans; Hygiene; Immune response; Immune response (humoral); Immune system; Immunogenicity; Immunoglobulins; Infections; Laboratories; Medicine; Mice; Mice, Inbred BALB C; Neutralization; Neutralization Tests; Neutralizing; Plasma; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Studies; T-Lymphocytes, Cytotoxic - immunology; Tat protein; Vaccines; Virology; Viruses; United States > US; Africa; California; Thailand; Nigeria; Maryland; Sub-Saharan Africa; Germany

Creation of an effective vaccine for HIV has been an elusive goal of the scientific community for almost 30 years. Neutralizing antibodies are assumed to be pivotal to the success of a prophylactic vaccine but previous attempts to make an immunogen capable of generating neutralizing antibodies to pr...