RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients
RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it...
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Published in | PloS one Vol. 5; no. 12; p. e15737 |
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Main Authors | , , , , , , , , , , , , , , , , |
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22.12.2010
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Abstract | RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval =1.566-9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination. |
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AbstractList | RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval = 1.566-9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination. RB1 -inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval = 1.566–9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination. |
Audience | Academic |
Author | Hisa, Yasuo Tameno, Hitosuke Inoue, Hirokazu Tomita, Yasuhiko Ochi, Yasuko Nishimura, Ichiro Jin, Yufen Ikebuchi, Kaichiro Okabe, Hidetoshi Teramoto, Koji Chano, Tokuhiro Ishitobi, Makoto Minami, Kahori Isono, Takahiro Inaji, Hideo Saitoh, Masao Shimada, Taketoshi |
AuthorAffiliation | 2 Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan 3 Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan 5 Department of Thoracic Surgery, Shiga University of Medical Science, Otsu, Japan 8 Department of Cellular Physiological Chemistry, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo, Japan 7 Department Central Research Laboratory, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo, Japan Bauer Research Foundation, United States of America 4 Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan 6 Department of Microbiology, Shiga University of Medical Science, Otsu, Japan 1 Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan |
AuthorAffiliation_xml | – name: 4 Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan – name: 5 Department of Thoracic Surgery, Shiga University of Medical Science, Otsu, Japan – name: Bauer Research Foundation, United States of America – name: 1 Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan – name: 6 Department of Microbiology, Shiga University of Medical Science, Otsu, Japan – name: 7 Department Central Research Laboratory, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo, Japan – name: 8 Department of Cellular Physiological Chemistry, Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo, Japan – name: 3 Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan – name: 2 Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan |
Author_xml | – sequence: 1 givenname: Tokuhiro surname: Chano fullname: Chano, Tokuhiro email: chano@belle.shiga-med.ac.jp organization: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan. chano@belle.shiga-med.ac.jp – sequence: 2 givenname: Kaichiro surname: Ikebuchi fullname: Ikebuchi, Kaichiro – sequence: 3 givenname: Yasuhiko surname: Tomita fullname: Tomita, Yasuhiko – sequence: 4 givenname: Yufen surname: Jin fullname: Jin, Yufen – sequence: 5 givenname: Hideo surname: Inaji fullname: Inaji, Hideo – sequence: 6 givenname: Makoto surname: Ishitobi fullname: Ishitobi, Makoto – sequence: 7 givenname: Koji surname: Teramoto fullname: Teramoto, Koji – sequence: 8 givenname: Yasuko surname: Ochi fullname: Ochi, Yasuko – sequence: 9 givenname: Hitosuke surname: Tameno fullname: Tameno, Hitosuke – sequence: 10 givenname: Ichiro surname: Nishimura fullname: Nishimura, Ichiro – sequence: 11 givenname: Kahori surname: Minami fullname: Minami, Kahori – sequence: 12 givenname: Hirokazu surname: Inoue fullname: Inoue, Hirokazu – sequence: 13 givenname: Takahiro surname: Isono fullname: Isono, Takahiro – sequence: 14 givenname: Masao surname: Saitoh fullname: Saitoh, Masao – sequence: 15 givenname: Taketoshi surname: Shimada fullname: Shimada, Taketoshi – sequence: 16 givenname: Yasuo surname: Hisa fullname: Hisa, Yasuo – sequence: 17 givenname: Hidetoshi surname: Okabe fullname: Okabe, Hidetoshi |
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Copyright | COPYRIGHT 2010 Public Library of Science 2010 Chano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Chano et al. 2010 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: TC HO. Performed the experiments: KI YT YJ HI MI KT YO HT IN KM TS YH. Analyzed the data: TC KI. Contributed reagents/materials/analysis tools: HI TI MS. Wrote the paper: TC KI HO. |
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SubjectTerms | Abnormalities Adult Aged Aged, 80 and over Analysis Apoptosis Autophagy Biology Biomarkers Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - genetics Cancer Cancer patients Cell cycle Cell Nucleus - metabolism Cohort Studies Confidence intervals Correlation Correlation analysis Development and progression Disease Epidermal growth factor Estrogens Female Gene Expression Regulation, Neoplastic Genotype & phenotype Hazards Health risks Humans Immunohistochemistry - methods Japan Kinases Laboratories Medical prognosis Medical research Medicine Middle Aged Otolaryngology p53 Protein Pathogenesis Patient outcomes Patients Progesterone Prognosis Proportional Hazards Models Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - genetics Regression analysis Retina Retinoblastoma Retinoblastoma Protein - biosynthesis Science Senescence Signal transduction Statistical analysis Statistical tests Surgery Survival Thoracic surgery Tissues Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - biosynthesis Tumorigenesis |
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Title | RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients |
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