Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans

• Published in: PloS one Vol. 7; no. 2; p. e32338
• Main Authors: Delaney, Jessica T, Jeff, Janina M, Brown, Nancy J, Pretorius, Mias, Okafor, Henry E, Darbar, Dawood, Roden, Dan M, Crawford, Dana C
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.02.2012; Public Library of Science (PLoS)
• Subjects: African American studies; African Americans; Atrial fibrillation; Atrial Fibrillation - ethnology; Atrial Fibrillation - genetics; Biology; Biomarkers; Biophysics; Black or African American - genetics; Black People - genetics; Breast cancer; Cardiac arrhythmia; Case-Control Studies; Chromosomes; Confidence intervals; Descent; Diabetes; Enrollments; Female; Fibrillation; Gene expression; Gene loci; Genealogy; Genetic aspects; Genetic Predisposition to Disease; Genetic research; Genetic Variation; Genome-Wide Association Study; Genomes; Genomics; Genotype; HapMap Project; Heart diseases; Heart surgery; Humans; Hypertension; Male; Medicine; Middle Aged; Minority & ethnic groups; Models, Genetic; Models, Statistical; Odds Ratio; Physiology; Polymorphism, Single Nucleotide; Population; Population studies; Populations; Postoperative period; Review boards; Risk; Risk analysis; Risk factors; Statistical analysis; Studies; Surgery; White People - genetics; United States > US; Tennessee; Nashville Tennessee

Despite a greater burden of risk factors, atrial fibrillation (AF) is less common among African Americans than European-descent populations. Genome-wide association studies (GWAS) for AF in European-descent populations have identified three predominant genomic regions associated with increased risk...