Comparative mRNA and microRNA Expression Profiling of Three Genitourinary Cancers Reveals Common Hallmarks and Cancer-Specific Molecular Events

• Published in: PloS one Vol. 6; no. 7; p. e22570
• Main Authors: Li, Xianxin, Chen, Jiahao, Hu, Xueda, Huang, Yi, Li, Zhizhong, Zhou, Liang, Tian, Zhijian, Ma, Hongyu, Wu, Zhiyun, Chen, Maoshan, Han, Zujing, Peng, Zhiyu, Zhao, Xiaokun, Liang, Chaozhao, Wang, Yong, Sun, Liang, Chen, Jing, Zhao, Jun, Jiang, Binghua, Yang, Huanming, Gui, Yaoting, Cai, Zhiming, Zhang, Xiuqing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.07.2011; Public Library of Science (PLoS)
• Subjects: Aberration; Biology; Biomarkers; Biomarkers, Tumor - genetics; Bladder; Bladder cancer; Calcium; Calcium signalling; Cancer; Carcinoma; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Cell adhesion; Cell cycle; Cell migration; Cluster analysis; Clustering; Comparative analysis; Correlation analysis; Deoxyribonucleic acid; Depth profiling; Deregulation; Development and progression; Diagnostic software; Diagnostic systems; DNA; DNA biosynthesis; DNA repair; Extracellular matrix; Gene expression; Gene Expression Profiling; Gene sequencing; Genes; Genetic aspects; Genetics; Genomes; Genomics; Health aspects; Humans; Inflammation; Inflammatory response; Kidneys; Laboratories; Liver cancer; Male; Medicine; Messenger RNA; Metabolic pathways; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Neoplasms, Germ Cell and Embryonal - genetics; Neoplasms, Germ Cell and Embryonal - metabolism; Neoplasms, Germ Cell and Embryonal - pathology; p53 Protein; Pancreatic cancer; Prostate cancer; Reproductive health; Ribonucleic acid; RNA; RNA, Messenger - genetics; Signal transduction; Suppressors; Testicular cancer; Testicular Neoplasms - genetics; Testicular Neoplasms - metabolism; Testicular Neoplasms - pathology; Therapeutic applications; Tumor proteins; Tumors; Urinary bladder; Urogenital Neoplasms - genetics; Urogenital Neoplasms - metabolism; Urogenital Neoplasms - pathology; Urology; Beijing China; China

Genome-wide gene expression profile using deep sequencing technologies can drive the discovery of cancer biomarkers and therapeutic targets. Such efforts are often limited to profiling the expression signature of either mRNA or microRNA (miRNA) in a single type of cancer. Here we provided an integra...