Characterization of a FGF19 Variant with Altered Receptor Specificity Revealed a Central Role for FGFR1c in the Regulation of Glucose Metabolism

• Published in: PloS one Vol. 7; no. 3; p. e33603
• Main Authors: Ge, Hongfei, Baribault, Helene, Vonderfecht, Steven, Lemon, Bryan, Weiszmann, Jennifer, Gardner, Jonitha, Lee, Ki Jeong, Gupte, Jamila, Mookherjee, Paramita, Wang, Minghan, Sheng, Jackie, Wu, Xinle, Li, Yang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.03.2012; Public Library of Science (PLoS)
• Subjects: Acids; Animal models; Animals; Bile; Biology; Blotting, Western; Cell Line; Dependovirus - genetics; Diabetes mellitus; Diabetes therapy; Energy balance; Energy metabolism; Epidemics; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblasts; Gene therapy; Genetic disorders; Genetic Vectors; Glucose; Glucose - metabolism; Glucose Tolerance Test; Growth factors; Heparan sulfate; Homeostasis; Hormones; Kinases; Leptin; Lipid metabolism; Lipids; Liver - metabolism; Liver cancer; Male; Medicine; Metabolism; Mice; Musculoskeletal system; Normalizing; Obesity; Pandemics; Physiological aspects; Protein Binding; Receptor, Fibroblast Growth Factor, Type 1 - metabolism; Receptor, Fibroblast Growth Factor, Type 1 - physiology; Rodents; Signal Transduction; Transgenic animals; Tumorigenesis; Type 2 diabetes; Yang, Cindy; United States > US; San Francisco California; California

Diabetes and associated metabolic conditions have reached pandemic proportions worldwide, and there is a clear unmet medical need for new therapies that are both effective and safe. FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones. Both have potent effect...