PTEN as a prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of the head and neck

• Published in: PloS one Vol. 7; no. 3; p. e33396
• Main Authors: Snietura, Miroslaw, Jaworska, Magdalena, Mlynarczyk-Liszka, Joanna, Goraj-Zajac, Aleksandra, Piglowski, Wojciech, Lange, Dariusz, Wozniak, Grzegorz, Nowara, Elzbieta, Suwinski, Rafal
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2012; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Analysis; Angiogenesis; Biology; Biomarkers, Tumor - metabolism; Breast cancer; Cancer; Cancer therapies; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - radiotherapy; Cell survival; Chromosomes; Colorectal cancer; Combined Modality Therapy; Cyclin D1; Epidermal growth factor receptors; Evidence-based medicine; Female; Fractionation; Head; Head & neck cancer; Head and neck cancer; Head and Neck Neoplasms - diagnosis; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - radiotherapy; Health aspects; Health risks; Histology; Human papillomavirus; Humans; Kinases; Larynx; Male; Medical research; Medicine; Metastasis; Middle Aged; Neoplasia; Neoplasm Grading; Neoplasms; Nucleoside-diphosphate kinase; Oncology; Oral cancer; Oral cavity; Oropharynx; p53 Protein; Paraffin; Pathology; Patients; Phosphatase; Postoperative Period; Prognosis; Prostate; Prostate cancer; PTEN Phosphohydrolase - metabolism; PTEN protein; Radiation therapy; Radiotherapy; Risk Factors; Senescence; Signal transduction; Squamous cell carcinoma; Thyroid; Thyroid cancer; Thyroid gland; Treatment Outcome; Tumor proteins; Tumor suppressor genes; Tumorigenesis; Tumors; Poland

Tumor suppressor PTEN is known to control a variety of processes related to cell survival, proliferation, and growth. PTEN expression is considered as a prognostic factor in some human neoplasms like breast, prostate, and thyroid cancer. In this study we analyzed the influence of PTEN expression on...