The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly
Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influ...
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| Published in | ENDOCRINE JOURNAL Vol. 65; no. 1; pp. 91 - 99 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The Japan Endocrine Society
01.01.2018
Japan Science and Technology Agency |
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| Online Access | Get full text |
| ISSN | 0918-8959 1348-4540 1348-4540 |
| DOI | 10.1507/endocrj.EJ17-0300 |
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| Abstract | Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33–60) pg/mL and 1,313.7 (155–1,902) μM in acromegaly; and 46.3 (38–95) pg/mL and 1,607.3 (195–1,981) μM in healthy subjects (p < 0.001, p < 0.001). SOD levels were decreased in controlled and uncontrolled patients compared to healthy subjects (p = 0.05 and p = 0.002, respectively). Controlled and uncontrolled acromegaly displayed significantly decreased levels of TAC compared to healthy subjects (p < 0.05 and p < 0.001, respectively). SOD levels were not associated with MnSOD polymorphisms in acromegaly. In conclusion, this study showed that acromegaly was associated with decreased levels of SOD and TAC, and controlling the disease activity could not adequately improve these levels. |
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| AbstractList | Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33-60) pg/mL and 1,313.7 (155-1,902) μM in acromegaly; and 46.3 (38-95) pg/mL and 1,607.3 (195-1,981) μM in healthy subjects (p < 0.001, p < 0.001). SOD levels were decreased in controlled and uncontrolled patients compared to healthy subjects (p = 0.05 and p = 0.002, respectively). Controlled and uncontrolled acromegaly displayed significantly decreased levels of TAC compared to healthy subjects (p < 0.05 and p < 0.001, respectively). SOD levels were not associated with MnSOD polymorphisms in acromegaly. In conclusion, this study showed that acromegaly was associated with decreased levels of SOD and TAC, and controlling the disease activity could not adequately improve these levels.Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33-60) pg/mL and 1,313.7 (155-1,902) μM in acromegaly; and 46.3 (38-95) pg/mL and 1,607.3 (195-1,981) μM in healthy subjects (p < 0.001, p < 0.001). SOD levels were decreased in controlled and uncontrolled patients compared to healthy subjects (p = 0.05 and p = 0.002, respectively). Controlled and uncontrolled acromegaly displayed significantly decreased levels of TAC compared to healthy subjects (p < 0.05 and p < 0.001, respectively). SOD levels were not associated with MnSOD polymorphisms in acromegaly. In conclusion, this study showed that acromegaly was associated with decreased levels of SOD and TAC, and controlling the disease activity could not adequately improve these levels. Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33-60) pg/mL and 1,313.7 (155-1,902) μM in acromegaly; and 46.3 (38-95) pg/mL and 1,607.3 (195-1,981) μM in healthy subjects (p < 0.001, p < 0.001). SOD levels were decreased in controlled and uncontrolled patients compared to healthy subjects (p = 0.05 and p = 0.002, respectively). Controlled and uncontrolled acromegaly displayed significantly decreased levels of TAC compared to healthy subjects (p < 0.05 and p < 0.001, respectively). SOD levels were not associated with MnSOD polymorphisms in acromegaly. In conclusion, this study showed that acromegaly was associated with decreased levels of SOD and TAC, and controlling the disease activity could not adequately improve these levels. [Abstract.] Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33-60)pg/mL and 1,313.7 (155-1,902)μM in acromegaly; and 46.3 (38-95)pg/mL and 1,607.3 (195-1,981)μM in healthy subjects (p<0.001, p<0.001). SOD levels were decreased in controlled and uncontrolled patients compared to healthy subjects (p=0.05 and p=0.002, respectively). Controlled and uncontrolled acromegaly displayed significantly decreased levels of TAC compared to healthy subjects (p<0.05 and p<0.001, respectively). SOD levels were not associated with MnSOD polymorphisms in acromegaly. In conclusion, this study showed that acromegaly was associated with decreased levels of SOD and TAC, and controlling the disease activity could not adequately improve these levels. |
| Author | Turgut, Seda Turan, Saime Dursun, Gurbet Korkmaz Mezani, Brunilda Ergen, Hayriye Arzu Tasan, Ertugrul Yaylim, Ilhan Cekic, Sema Demirci Ilhan, Muzaffer Karaman, Ozcan Apak, Mustafa Resat |
| Author_xml | – sequence: 1 fullname: Ilhan, Muzaffer organization: Department of Endocrinology and Metabolism, Bezmialem Vakif University, Vatan Caddesi, 34093, Istanbul, Turkey – sequence: 1 fullname: Turgut, Seda organization: Department of Endocrinology and Metabolism, Bezmialem Vakif University, Vatan Caddesi, 34093, Istanbul, Turkey – sequence: 1 fullname: Tasan, Ertugrul organization: Department of Endocrinology and Metabolism, Bezmialem Vakif University, Vatan Caddesi, 34093, Istanbul, Turkey – sequence: 1 fullname: Ergen, Hayriye Arzu organization: The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Millet Caddesi, Capa, 34104, İstanbul, Turkey – sequence: 1 fullname: Yaylim, Ilhan organization: The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Millet Caddesi, Capa, 34104, İstanbul, Turkey – sequence: 1 fullname: Turan, Saime organization: The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Millet Caddesi, Capa, 34104, İstanbul, Turkey – sequence: 1 fullname: Cekic, Sema Demirci organization: Department of Chemistry, Faculty of Engineering, Istanbul University, Millet Caddesi, Capa, 34104, İstanbul, Turkey – sequence: 1 fullname: Dursun, Gurbet Korkmaz organization: The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Millet Caddesi, Capa, 34104, İstanbul, Turkey – sequence: 1 fullname: Karaman, Ozcan organization: Department of Endocrinology and Metabolism, Bezmialem Vakif University, Vatan Caddesi, 34093, Istanbul, Turkey – sequence: 1 fullname: Mezani, Brunilda organization: The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Millet Caddesi, Capa, 34104, İstanbul, Turkey – sequence: 1 fullname: Apak, Mustafa Resat organization: Department of Chemistry, Faculty of Engineering, Istanbul University, Millet Caddesi, Capa, 34104, İstanbul, Turkey |
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| CitedBy_id | crossref_primary_10_3389_fendo_2019_00437 crossref_primary_10_3389_fpsyt_2021_684445 crossref_primary_10_1007_s11154_020_09560_x crossref_primary_10_1177_0006355X241290980 crossref_primary_10_1186_s12951_024_02383_x crossref_primary_10_3389_fphar_2021_565748 crossref_primary_10_1007_s42000_022_00409_3 crossref_primary_10_1007_s12020_023_03444_1 crossref_primary_10_1016_j_jclepro_2022_133794 |
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| References_xml | – reference: 23 Yarman S, Ozden TA, Gokkusu C (2003) The evaluation of lipid peroxidation and acute effect of octreotide on lipid peroxidation in patients with active acromegaly. Clin Chim Acta 336: 45–48. – reference: 34 Grasbon-Frodl EM, Kosel S, Riess O, Muller U, Mehraein P, et al. (1999) Analysis of mitochondrial targeting sequence and coding region polymorphisms of the manganese superoxide dismutase gene in German Parkinson disease patients. Biochem Biophys Res Commun 255: 749–752. – reference: 27 Abdilla N, Tormo MC, Fabia MJ, Chaves FJ, Saez G, et al. (2007) Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension. J Hum Hypertens 21: 68–75. – reference: 3 Maison P, Demolis P, Young J, Schaison G, Giudicelli JF, et al. (2000) Vascular reactivity in acromegalic patients: preliminary evidence for regional endothelial dysfunction and increased sympathetic vasoconstriction. 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| Snippet | Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we... [Abstract.] Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this... |
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| SubjectTerms | Acromegaly Antioxidants Manganese Manganese compounds Oxidation Oxidative status Superoxide dismutase Total antioxidant capacity |
| Title | The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly |
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