Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model

• Published in: PloS one Vol. 6; no. 4; p. e18272
• Main Authors: Makarova, Natalia, Zhao, Chunxia, Zhang, Yuanyuan, Bhosle, Sushma, Suppiah, Suganthi, Rhea, Jeanne M, Kozyr, Natalia, Arnold, Rebecca S, Ly, Hinh, Molinaro, Ross J, Parslow, Tristram G, Hunter, Eric, Liotta, Dennis, Petros, John, Blackwell, Jerry L
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.04.2011; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Adenoviruses; Animal models; Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody Formation - immunology; Antibody Specificity - immunology; Binding; Biological warfare; Biology; Cancer; Carcinogenesis; Carcinogens; Cell Line; Chronic fatigue syndrome; Codons; Enzyme-linked immunosorbent assay; Fatigue; Gag protein; Gene sequencing; Genetic Vectors - genetics; Glycoproteins; Health aspects; Health risks; HIV; Human immunodeficiency virus; Humans; Immune response; Immune Sera - immunology; Immunization; Immunoassay; Immunogenicity; Immunoglobulins; In vivo methods and tests; Infection; Infections; Laboratories; Leukemia; Low level; Medicine; Mice; Models, Animal; Mouse leukemia complex; Neutralization Tests; Pathology; Patients; Polypeptides; Prostate; Prostate cancer; Studies; Urology; Vaccination; Vaccines; Vectors; Viral Envelope Proteins - immunology; Virology; Virus-like particles; Viruses; Xenotropic; Xenotropic murine leukemia virus-related virus - immunology; Xenotropic murine leukemia virus-related virus - metabolism; Xenotropic murine leukemia virus-related virus - ultrastructure; Atlanta Georgia; United States > US; Georgia

Xenotropic murine leukemia virus-related virus (XMRV) was recently discovered to be the first human gammaretrovirus that is associated with chronic fatigue syndrome and prostate cancer (PC). Although a mechanism for XMRV carcinogenesis is yet to be established, this virus belongs to the family of ga...