In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks

• Published in: PloS one Vol. 7; no. 1; p. e29853
• Main Authors: Rothkamm, Kai, Crosbie, Jeffrey C, Daley, Frances, Bourne, Sarah, Barber, Paul R, Vojnovic, Borivoj, Cann, Leonie, Rogers, Peter A W
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.01.2012; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Beams (radiation); Biology; Calibration; Cancer therapies; Cell cycle; Cells, Cultured; Communication; Computer simulation; Deoxyribonucleic acid; DNA; DNA damage; Dose-Response Relationship, Radiation; Dosimeters; Dosimetry; Female; Fibroblasts; Fibroblasts - pathology; Fibroblasts - radiation effects; Genomes; Gynecology; Humans; Mapping; Medicine; Mice; Mice, Inbred BALB C; Microbeams; Monte Carlo methods; Monte Carlo simulation; Obstetrics; Oncology; Organs at Risk - radiation effects; Physics; Radiation; Radiation (Physics); Radiation damage; Radiation dosage; Radiation effects; Radiation Oncology - methods; Radiation therapy; Radiometry - methods; Radiotherapy; Radiotherapy - adverse effects; Radiotherapy - methods; Radiotherapy Dosage; Skin; Skin - pathology; Skin - radiation effects; Spatial distribution; Synchrotrons; Tissues; Tumors; Valleys; Womens health; X-rays; X-Rays - adverse effects; Victoria Australia; United Kingdom > UK; Australia; United States > US

Microbeam radiation therapy (MRT) using high doses of synchrotron X-rays can destroy tumours in animal models whilst causing little damage to normal tissues. Determining the spatial distribution of radiation doses delivered during MRT at a microscopic scale is a major challenge. Film and semiconduct...