The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation
Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arres...
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Published in | PloS one Vol. 6; no. 12; p. e28723 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Public Library of Science
12.12.2011
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Abstract | Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arrestin-dependent activation of extracellular signal-regulated kinase 1/2 (ERK1/2) has been demonstrated. Here we have performed in vitro binding assays with pure proteins to demonstrate for the first time that ERK2 directly binds free arrestin-2 and -3, as well as receptor-associated arrestins-1, -2, and -3. In addition, we showed that in COS-7 cells arrestin-2 and -3 association with β(2)-adrenergic receptor (β2AR) significantly enhanced ERK2 binding, but showed little effect on arrestin interactions with the upstream kinases c-Raf1 and MEK1. Arrestins exist in three conformational states: free, receptor-bound, and microtubule-associated. Using conformationally biased arrestin mutants we found that ERK2 preferentially binds two of these: the "constitutively inactive" arrestin-Δ7 mimicking microtubule-bound state and arrestin-3A, a mimic of the receptor-bound conformation. Both rescue arrestin-mediated ERK1/2/activation in arrestin-2/3 double knockout fibroblasts. We also found that arrestin-2-c-Raf1 interaction is enhanced by receptor binding, whereas arrestin-3-c-Raf1 interaction is not. |
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AbstractList | Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arrestin-dependent activation of extracellular signal-regulated kinase 1/2 (ERK1/2) has been demonstrated. Here we have performed in vitro binding assays with pure proteins to demonstrate for the first time that ERK2 directly binds free arrestin-2 and -3, as well as receptor-associated arrestins-1, -2, and -3. In addition, we showed that in COS-7 cells arrestin-2 and -3 association with [beta].sub.2 -adrenergic receptor ([beta]2AR) significantly enhanced ERK2 binding, but showed little effect on arrestin interactions with the upstream kinases c-Raf1 and MEK1. Arrestins exist in three conformational states: free, receptor-bound, and microtubule-associated. Using conformationally biased arrestin mutants we found that ERK2 preferentially binds two of these: the "constitutively inactive" arrestin-[DELTA]7 mimicking microtubule-bound state and arrestin-3A, a mimic of the receptor-bound conformation. Both rescue arrestin-mediated ERK1/2/activation in arrestin-2/3 double knockout fibroblasts. We also found that arrestin-2-c-Raf1 interaction is enhanced by receptor binding, whereas arrestin-3-c-Raf1 interaction is not. Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arrestin-dependent activation of extracellular signal-regulated kinase 1/2 (ERK1/2) has been demonstrated. Here we have performed in vitro binding assays with pure proteins to demonstrate for the first time that ERK2 directly binds free arrestin-2 and -3, as well as receptor-associated arrestins-1, -2, and -3. In addition, we showed that in COS-7 cells arrestin-2 and -3 association with β(2)-adrenergic receptor (β2AR) significantly enhanced ERK2 binding, but showed little effect on arrestin interactions with the upstream kinases c-Raf1 and MEK1. Arrestins exist in three conformational states: free, receptor-bound, and microtubule-associated. Using conformationally biased arrestin mutants we found that ERK2 preferentially binds two of these: the "constitutively inactive" arrestin-Δ7 mimicking microtubule-bound state and arrestin-3A, a mimic of the receptor-bound conformation. Both rescue arrestin-mediated ERK1/2/activation in arrestin-2/3 double knockout fibroblasts. We also found that arrestin-2-c-Raf1 interaction is enhanced by receptor binding, whereas arrestin-3-c-Raf1 interaction is not. Arrestins are multifunctional signaling adaptors originally discovered as proteins that “arrest” G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arrestin-dependent activation of extracellular signal-regulated kinase 1/2 (ERK1/2) has been demonstrated. Here we have performed in vitro binding assays with pure proteins to demonstrate for the first time that ERK2 directly binds free arrestin-2 and -3, as well as receptor-associated arrestins-1, -2, and -3. In addition, we showed that in COS-7 cells arrestin-2 and -3 association with β2-adrenergic receptor (β2AR) significantly enhanced ERK2 binding, but showed little effect on arrestin interactions with the upstream kinases c-Raf1 and MEK1. Arrestins exist in three conformational states: free, receptor-bound, and microtubule-associated. Using conformationally biased arrestin mutants we found that ERK2 preferentially binds two of these: the “constitutively inactive” arrestin-Δ7 mimicking microtubule-bound state and arrestin-3A, a mimic of the receptor-bound conformation. Both rescue arrestin-mediated ERK1/2/activation in arrestin-2/3 double knockout fibroblasts. We also found that arrestin-2-c-Raf1 interaction is enhanced by receptor binding, whereas arrestin-3-c-Raf1 interaction is not. Arrestins are multifunctional signaling adaptors originally discovered as proteins that “arrest” G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arrestin-dependent activation of extracellular signal-regulated kinase 1/2 (ERK1/2) has been demonstrated. Here we have performed in vitro binding assays with pure proteins to demonstrate for the first time that ERK2 directly binds free arrestin-2 and -3, as well as receptor-associated arrestins-1, -2, and -3. In addition, we showed that in COS-7 cells arrestin-2 and -3 association with β 2 -adrenergic receptor (β2AR) significantly enhanced ERK2 binding, but showed little effect on arrestin interactions with the upstream kinases c-Raf1 and MEK1. Arrestins exist in three conformational states: free, receptor-bound, and microtubule-associated. Using conformationally biased arrestin mutants we found that ERK2 preferentially binds two of these: the “constitutively inactive” arrestin-Δ7 mimicking microtubule-bound state and arrestin-3A, a mimic of the receptor-bound conformation. Both rescue arrestin-mediated ERK1/2/activation in arrestin-2/3 double knockout fibroblasts. We also found that arrestin-2-c-Raf1 interaction is enhanced by receptor binding, whereas arrestin-3-c-Raf1 interaction is not. |
Audience | Academic |
Author | Kook, Seunghyi Hanson, Susan M Coffa, Sergio Gurevich, Vsevolod V Breitman, Maya Callaway, Kari Dalby, Kevin N |
AuthorAffiliation | 1 Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America Hungarian Academy of Sciences, Hungary 2 Division of Medicinal Chemistry, The University of Texas at Austin, Austin, Texas, United States of America |
AuthorAffiliation_xml | – name: 2 Division of Medicinal Chemistry, The University of Texas at Austin, Austin, Texas, United States of America – name: 1 Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America – name: Hungarian Academy of Sciences, Hungary |
Author_xml | – sequence: 1 givenname: Sergio surname: Coffa fullname: Coffa, Sergio organization: Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America – sequence: 2 givenname: Maya surname: Breitman fullname: Breitman, Maya – sequence: 3 givenname: Susan M surname: Hanson fullname: Hanson, Susan M – sequence: 4 givenname: Kari surname: Callaway fullname: Callaway, Kari – sequence: 5 givenname: Seunghyi surname: Kook fullname: Kook, Seunghyi – sequence: 6 givenname: Kevin N surname: Dalby fullname: Dalby, Kevin N – sequence: 7 givenname: Vsevolod V surname: Gurevich fullname: Gurevich, Vsevolod V |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22174878$$D View this record in MEDLINE/PubMed |
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Copyright | COPYRIGHT 2011 Public Library of Science 2011 Coffa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Coffa et al. 2011 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: SC MB SMH KND VVG. Performed the experiments: SC MB SMH KC SK. Analyzed the data: SC MB SMH KND VVG. Contributed reagents/materials/analysis tools: SC MB KC SK. Wrote the paper: SC KND VVG. Current address: Carroll University, Waukesha, Wisconsin, United States of America |
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Snippet | Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs).... Arrestins are multifunctional signaling adaptors originally discovered as proteins that “arrest” G protein activation by G protein-coupled receptors (GPCRs).... |
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SubjectTerms | Activation Adapters Adaptor proteins Adrenergic receptors Animals Arrestin Arrestin - chemistry Arrestin - metabolism Arrestins - chemistry Arrestins - metabolism beta-Arrestins Binding Biochemistry Biology Cattle Chlorocebus aethiops COS Cells Embryo, Mammalian - cytology Enzyme Activation Extracellular signal-regulated kinase Fibroblasts Fibroblasts - enzymology G protein-coupled receptors G proteins HEK293 Cells Humans Kinases Ligands MAP Kinase Kinase 1 - metabolism Mice Mice, Knockout Mimicry Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mutagenesis Mutant Proteins - chemistry Mutant Proteins - metabolism Mutants Pharmaceutical sciences Pharmacology Phosphorylation Phosphotransferases Photoreceptors Protein Binding Protein Conformation Proteins Proto-Oncogene Proteins c-raf - metabolism Receptors Receptors, Adrenergic, beta-2 - metabolism Recruitment Signaling Structure-Activity Relationship |
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Title | The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation |
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